TWAS
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Models
Genes
Traits
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Traits
:
Arm fat mass (left)
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chr2:68,850,921-70,593,838
Best TWAS P=7.05e-09 · Best GWAS P=2.03e-07 conditioned to 0.938
68.8M
69M
69.2M
69.4M
69.6M
69.8M
70M
70.2M
70.4M
70.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
GFPT1
0.05
0.00
blup
67
0.02
5.9e-03
-5.1
5.8
7.1e-09
-0.89
0.01
0.74
TRUE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
GFPT1
0.12
0.05
blup
67
0.04
3.9e-05
-5.1
5.3
9.0e-08
-0.93
0.01
0.99
FALSE
2
GTEx
Nerve Tibial
GFPT1
0.13
0.01
lasso
4
0.02
1.8e-02
-5.1
5.3
1.1e-07
-0.89
0.03
0.89
FALSE
1
GTEx
Cells Transformed fibroblasts
AAK1
0.08
0.05
lasso
5
0.03
1.4e-03
-5.0
-5.1
2.9e-07
0.93
0.03
0.97
FALSE