Best TWAS P=7.05e-09 · Best GWAS P=2.03e-07 conditioned to 0.938
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | AAK1 | 0.08 | 0.05 | lasso | 5 | 0.03 | 1.4e-03 | -5.0 | -5.1 | 2.9e-07 | 0.93 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -5.1 | 5.3 | 1.1e-07 | -0.89 | 0.03 | 0.89 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -5.1 | 5.8 | 7.1e-09 | -0.89 | 0.01 | 0.74 | TRUE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GFPT1 | 0.12 | 0.05 | blup | 67 | 0.04 | 3.9e-05 | -5.1 | 5.3 | 9.0e-08 | -0.93 | 0.01 | 0.99 | FALSE |