Best TWAS P=1.99e-13 · Best GWAS P=3.17e-12 conditioned to 0.0744
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | YFS | Blood | AP3B1 | 0.25 | 0.22 | lasso | 9 | 0.23 | 2.6e-74 | 5.7 | -5.9 | 4.0e-09 | 0.31 | 0.92 | 0.08 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -6.8 | -7.2 | 8.4e-13 | 0.86 | 0.02 | 0.90 | FALSE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 6.0 | -5.9 | 4.3e-09 | 0.53 | 0.04 | 0.54 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AP3B1 | 0.08 | 0.01 | enet | 20 | 0.02 | 9.7e-04 | -6.5 | -5.2 | 2.1e-07 | 0.58 | 0.02 | 0.80 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | AP3B1 | 0.05 | 0.03 | lasso | 3 | 0.04 | 4.4e-05 | 6.0 | -5.2 | 2.0e-07 | 0.36 | 0.34 | 0.40 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 6.1 | -7.3 | 2.0e-13 | 0.80 | 0.02 | 0.91 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | AP3B1 | 0.11 | 0.06 | lasso | 2 | 0.05 | 1.3e-05 | 5.7 | -5.4 | 6.8e-08 | 0.20 | 0.56 | 0.11 | FALSE |