Best TWAS P=3.63e-10 · Best GWAS P=1.61e-10 conditioned to 0.00419
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DAGLB | 0.09 | 0.09 | lasso | 5 | 0.09 | 5.7e-11 | 5.1 | -5.3 | 1.2e-07 | -0.46 | 0.64 | 0.36 | FALSE |
| 2 | GTEx | Nerve Tibial | RAC1 | 0.19 | 0.07 | enet | 28 | 0.09 | 6.2e-07 | 5.4 | 5.6 | 1.7e-08 | 0.56 | 0.52 | 0.46 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | DAGLB | 0.09 | 0.06 | lasso | 5 | 0.06 | 4.8e-08 | 6.3 | -6.2 | 5.9e-10 | -0.83 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAC1 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.8e-05 | 4.9 | 6.3 | 3.6e-10 | 0.69 | 0.10 | 0.81 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAC1 | 0.08 | 0.02 | blup | 63 | 0.06 | 7.0e-07 | 4.7 | 5.7 | 1.4e-08 | 0.28 | 0.62 | 0.37 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | DAGLB | 0.06 | 0.02 | blup | 71 | 0.03 | 7.4e-04 | 5.3 | -6.1 | 1.1e-09 | -0.70 | 0.01 | 0.79 | FALSE |