Best TWAS P=1.13e-08 · Best GWAS P=8.28e-08 conditioned to 0.069
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | RP11-773H22.4 | 0.18 | 0.11 | lasso | 5 | 0.06 | 0.0063 | -5.4 | 5.2 | 2.4e-07 | -0.97 | 0.01 | 0.77 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SEH1L | 0.09 | 0.02 | enet | 25 | 0.03 | 0.0024 | -5.4 | 5.7 | 1.1e-08 | -0.72 | 0.00 | 0.99 | TRUE |
| 3 | GTEx | Pituitary | SEH1L | 0.22 | 0.07 | lasso | 6 | 0.05 | 0.0206 | -5.4 | 5.2 | 2.3e-07 | -0.89 | 0.02 | 0.69 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP192 | 0.06 | 0.05 | blup | 84 | 0.04 | 0.0015 | 4.2 | 5.1 | 3.1e-07 | -0.59 | 0.20 | 0.36 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SEH1L | 0.03 | 0.01 | blup | 60 | 0.01 | 0.0401 | -5.0 | 5.2 | 1.9e-07 | -0.87 | 0.00 | 0.63 | FALSE |