TWAS
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Genes
Traits
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Traits
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Arm fat-free mass (left)
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chr18:45,873,080-47,686,517
Best TWAS P=5.26e-12 · Best GWAS P=1.02e-15 conditioned to 0.0088
46M
46.5M
47M
47.5M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adrenal Gland
DYM
0.30
0.01
enet
15
0.01
1.2e-01
7.6
6.9
5.3e-12
0.81
0.02
0.83
TRUE
5
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
C18orf32
0.04
0.03
blup
48
0.04
6.5e-05
4.6
6.6
4.9e-11
0.57
0.00
0.99
TRUE
3
YFS
Blood
DYM
0.05
0.05
lasso
4
0.04
1.5e-13
-4.4
5.9
3.9e-09
0.76
1.00
0.00
FALSE
2
GTEx
Esophagus Mucosa
DYM
0.12
0.01
enet
12
0.04
1.0e-03
7.8
5.7
1.3e-08
0.73
0.01
0.96
FALSE
4
The Cancer Genome Atlas
Colon Adenocarcinoma
C18orf32
0.05
0.05
lasso
5
0.04
3.5e-03
-5.4
5.4
8.3e-08
0.41
0.03
0.45
FALSE