TWAS hub - DYM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2966	0.0955	1.7e-03	0.006	NA	0.012	NA	0.010	1.9e-01	NA	1.2e-01	NA	1.4e-01
2	GTEx	Esophagus Mucosa	0.1170	0.0420	1.1e-03	0.015	NA	0.040	NA	0.023	3.3e-02	NA	1.0e-03	NA	1.1e-02
3	YFS	Blood	0.0469	0.0117	7.1e-11	0.046	0.034	0.039	0.039	0.042	6.5e-15	1.9e-11	9.5e-13	8.8e-13	1.5e-13
4	TCGA	Breast Invasive Carcinoma	0.0224	0.0096	7.3e-05	0.007	0.022	0.010	NA	0.012	1.1e-02	2.2e-05	3.2e-03	NA	1.3e-03
5	TCGA	Prostate Adenocarcinoma	0.0688	0.0305	7.3e-05	0.033	0.029	0.030	NA	0.031	2.0e-04	4.2e-04	4.0e-04	NA	3.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Sitting height	23.3	165.5	320.2	14.6	13.6	17.9	2.8	10.1
Height	13.4	257.6	501.8	18.7	16.8	22.4	3.2	12.0
Standing height	11.6	114.7	216.1	12.8	11.0	14.7	2.2	8.2
Hand grip strength (left)	9.5	25.1	40.2	5.9	5.7	6.3	1.7	4.0
Forced expiratory volume in 1-second (FEV1), predicted	8.0	16.5	28.4	4.4	4.3	5.3	1.3	3.9
Hand grip strength (right)	7.7	21.0	34.9	5.9	5.4	5.9	0.0	2.6
Knee pain experienced in last month	6.3	9.7	12.0	-3.2	-3.3	-2.6	-3.5	-3.0
Arm fat-free mass (right)	5.0	25.5	50.0	7.1	5.9	6.0	0.3	2.6
Arm predicted mass (right)	4.9	25.0	49.5	7.0	5.9	5.7	0.3	2.8
Trunk fat-free mass	4.8	27.6	50.3	7.1	5.9	6.6	0.0	3.0
Trunk predicted mass	4.8	27.4	49.7	7.0	5.9	6.6	0.1	3.1
Arm fat-free mass (left)	4.8	24.5	47.6	6.9	5.7	5.9	0.5	2.8
Osteoarthritis (self-reported)	4.7	6.1	14.9	-2.6	-2.1	-3.9	-1.5	-1.5
Arm predicted mass (left)	4.5	22.8	44.8	6.7	5.4	5.7	0.2	2.7
Diabetes (mother)	4.3	5.5	9.7	1.9	2.2	3.1	1.6	2.6
Whole body fat-free mass	4.3	24.3	43.5	6.6	5.7	6.1	0.4	2.9
Whole body water mass	4.2	23.7	42.6	6.5	5.6	6.0	0.3	3.0
Lung cancer (father)	4.0	4.7	13.2	-1.6	-2.0	-0.5	-3.6	-1.9
Handedness (chirality/laterality): Left-handed	3.9	4.6	8.2	0.2	2.7	1.7	2.9	2.2
Comparative height size at age 10	3.6	19.8	37.0	6.1	4.6	5.2	1.4	3.5
Basal metabolic rate	3.6	19.7	36.2	6.0	5.2	5.4	0.5	2.5
Allergy or Eczema	3.5	9.2	14.3	-3.4	-2.9	-2.8	-2.0	-3.8
Medication: Co-codamol	3.3	3.8	6.8	-2.6	-1.6	-2.1	-0.6	-2.3
Supplements: Glucosamine	3.2	4.2	5.8	-2.4	-1.6	-2.1	-1.7	-2.4
Bipolar Disorder or Schizophrenia	3.0	7.3	12.5	1.8	2.7	3.5	1.3	3.5
Leg fat-free mass (right)	2.9	15.3	23.9	4.9	4.8	4.8	0.9	2.4
Leg predicted mass (right)	2.9	15.3	24.5	4.9	4.8	4.8	0.9	2.3
Schizophrenia (2018)	2.8	5.9	10.6	1.3	2.6	2.5	2.1	3.2
Leg fat-free mass (left)	2.8	15.1	24.6	5.0	4.5	4.8	0.9	2.6
Happiness	2.8	3.4	4.4	2.1	1.7	2.0	1.4	2.0
Waist Hip Ratio (WHR)	2.7	12.3	31.2	-2.7	-3.3	-5.6	2.4	-2.5
Leg predicted mass (left)	2.7	14.2	23.6	4.9	4.4	4.6	0.8	2.4
Chronic bronchitis/emphysema (mother)	2.7	3.1	7.9	-1.7	-0.9	-2.8	-0.9	-1.7
Mother’s age at death	2.7	3.4	7.6	-1.1	-2.8	-1.3	-2.0	-1.4
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	7.9	-0.6	-1.9	-1.6	-1.6	-2.8
Reaction Time	2.5	4.8	9.4	0.5	-2.3	-1.3	-2.7	-3.1
Forced vital capacity (FVC)	2.5	9.5	17.9	3.6	3.8	4.2	0.1	1.6
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	6.2	-1.4	-0.9	-2.5	2.2	1.0
Angina (self-reported)	2.5	3.2	6.9	0.1	-1.5	-2.0	2.6	1.7
Mean time to correctly identify matches	2.5	4.9	9.0	-0.5	-3.0	-1.9	-2.2	-2.5
Heart disease (siblings)	2.5	3.1	5.3	-2.1	-2.1	-2.3	-1.1	0.2
Angina	2.4	3.1	7.9	0.4	-1.0	-1.7	2.8	1.9
Hayfever, allergic rhinitis or eczema	2.4	5.2	8.7	-1.9	-2.5	-2.1	-1.6	-3.0
Hip circumference	2.4	10.4	18.8	3.9	4.3	3.3	1.0	2.4
Forced vital capacity (FVC), Best measure	2.4	8.8	18.3	3.5	3.4	4.3	-0.0	1.5
Forced expiratory volume in 1-second (FEV1)	2.3	7.7	14.7	3.0	3.5	3.8	0.8	1.6
Allergy	2.2	5.0	9.4	2.5	2.1	2.0	1.0	3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	6.7	0.6	0.8	1.3	2.1	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	14.4	2.8	3.0	3.8	0.3	1.6
Time employed in main current job	2.0	2.3	5.5	0.4	0.8	0.6	2.2	2.3
Medication: Blood pressure	2.0	3.5	7.2	-2.7	-1.3	-2.6	0.9	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.1	-1.4	-1.9	-2.0	-0.3	-1.5
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	2.9	1.7	1.6	1.4	1.3	1.3
Medication: Lisinopril	1.9	2.5	3.7	-1.9	-0.5	-1.3	-1.7	-1.9
Weight	1.8	9.0	16.8	4.1	3.8	3.2	0.9	1.6
Noisy workplace	1.8	2.3	3.4	-0.8	-1.7	-1.4	-1.8	-1.6
Medication: Amlodipine	1.8	2.5	6.3	-2.5	-0.0	-2.0	1.3	-0.8
Comparative body size at age 10	1.8	5.0	9.0	-1.9	-1.8	-2.6	-1.6	-3.0
Osteoporosis (self-reported)	1.8	2.2	5.3	-1.0	-1.0	-0.5	-2.3	-1.9
Bipolar Disorder (2011)	1.7	1.6	4.1	0.6	1.2	2.0	-1.5	0.2
Schizophrenia (2014)	1.7	3.8	6.7	1.0	2.1	2.3	1.2	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	8.8	0.3	1.2	3.0	0.3	0.8
Ulcerative Colitis	1.6	2.3	4.5	-2.1	-1.7	-1.3	1.1	1.1
Mouth/teeth dental problems	1.6	2.5	4.8	1.6	1.6	2.2	1.0	1.3
Gout (self-reported)	1.6	2.2	5.4	1.2	0.6	0.3	2.3	1.9
Heart disease (mother)	1.6	1.9	7.0	-2.6	-1.4	-0.7	0.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	2.9	-0.1	-1.0	-1.6	-1.7	-1.7
Financial situation satisfaction	1.6	2.0	5.7	1.0	2.4	1.5	0.7	0.8
Average weekly beer plus cider intake	1.6	2.4	8.9	-3.0	-0.9	-1.5	-0.0	0.1
Unable to work because of sickness or disability	1.6	2.0	4.4	-1.6	-2.1	-1.6	-0.6	-0.4
Alzheimer’s Disease (in father)	1.5	1.6	4.3	0.5	0.8	2.1	0.7	1.6
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.8	0.1	-0.8	-0.3	2.4	2.0
Ever had hysterectomy (womb removed)	1.5	1.7	4.2	-0.7	-2.1	-1.3	-1.1	-0.9
Glaucoma (self-reported)	1.5	1.8	4.6	-0.9	-2.1	-1.1	-0.6	-1.3
Mineral and other dietary supplements	1.5	2.1	4.6	1.4	2.1	0.5	1.2	1.4
Number of operations (self-reported)	1.5	2.2	3.8	-0.8	-1.3	-1.9	1.9	1.2
Bipolar Disorder (2018)	1.4	2.3	5.7	1.2	1.1	2.4	-0.5	1.6
Blood Platelet Count	1.4	16.0	23.9	-3.1	-4.1	-4.9	-3.3	-4.3
Fed-up feelings	1.4	2.6	4.3	0.7	1.6	1.4	1.9	2.1
Taking other prescription medications	1.4	2.1	4.7	-1.9	-2.2	-0.5	-0.9	-1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.7	-1.0	-0.4	-0.9	-1.3	-2.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.6	1.9	1.1	2.2	-1.2	0.8
Supplements: Vitamin C	1.4	1.7	2.4	1.5	1.6	1.4	0.6	1.1
Pain experienced in last month	1.4	2.3	4.2	1.0	1.5	1.6	2.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.1	-0.8	0.3	0.8	1.9	2.2
Qualifications: None of the above	1.3	2.8	8.2	-1.3	-0.2	-0.2	-2.0	-2.9
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.6	-0.2	0.5	-0.7	2.4	2.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	7.1	0.6	0.1	0.7	1.5	2.7
Number of full brothers	1.3	1.6	4.1	-0.0	1.1	0.7	1.6	2.0
Had major operations	1.3	1.5	3.9	-0.5	0.5	-0.6	1.7	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	5.1	0.1	0.4	-0.1	2.3	1.2
Medication: Aspirin	1.3	1.6	4.5	-0.1	0.1	0.6	1.8	2.1
Guilty feelings	1.3	1.9	2.9	0.7	1.7	1.4	1.5	1.5
Risk taking	1.3	1.8	4.5	0.0	1.2	-2.1	1.8	0.2
Rheumatoid Arthritis	1.2	1.6	3.1	-0.6	-1.8	-1.0	-1.4	-1.2
Number of treatments/medications taken	1.2	2.1	6.4	-2.5	-1.5	-1.1	0.1	-0.9
Medication: Atenolol	1.2	1.5	3.9	-0.1	-2.0	-1.8	0.3	-0.4
Pain all over the body in last month	1.2	1.2	2.9	-1.1	-1.7	-0.7	-0.5	-1.2
Arm fat percentage (right)	1.2	4.7	12.8	-2.3	-1.8	-3.6	0.5	-1.3
Number of full sisters	1.2	1.5	2.6	0.7	1.0	1.4	1.6	1.2
Suffer from ‘nerves’	1.2	1.8	5.1	-1.4	-2.3	-0.1	-1.1	-1.0
Age at First Birth	1.1	1.7	3.2	1.8	1.5	1.6	-0.5	0.2
Lung FVC	1.1	5.5	8.6	-2.0	-2.7	-2.9	-2.0	-1.9
Relative age of first facial hair	1.1	2.2	5.3	1.9	1.3	2.3	-0.4	0.5
Mouth/teeth dental problems: Dentures	1.1	1.9	2.8	-0.8	-1.1	-1.7	-1.6	-1.5
Depression (self-reported)	1.1	1.3	2.7	0.4	1.6	1.5	1.0	0.4
Peak expiratory flow (PEF)	1.1	2.6	6.0	2.5	1.9	1.2	1.0	1.1
Emphysema/chronic bronchitis	1.1	1.3	3.0	1.7	1.1	0.5	-0.6	-1.2
Overall health rating	1.1	2.4	4.7	-2.1	-1.6	-2.2	-0.0	-0.6
Miserableness	1.1	2.0	4.0	0.4	1.3	1.5	1.4	2.0
Eye problems/disorders: Glaucoma	1.1	1.3	3.6	-0.6	-1.9	-0.7	-0.2	-1.5
Fractured/broken bones in last 5 years	1.1	1.5	3.4	1.1	1.3	1.8	-1.0	0.4
Depression (Nagel 2018)	1.0	1.5	3.3	0.5	0.8	0.5	1.8	1.8
Alzheimer’s Disease (including proxy)	1.0	1.4	2.4	0.6	1.2	1.3	1.6	1.1
Mean Putamen Volume	1.0	1.1	3.0	-0.8	-0.8	-1.7	-0.2	-1.1
BMI	1.0	5.7	19.0	-1.2	-1.8	-4.4	-0.2	-2.2
Chronotype (morning person)	1.0	2.3	4.2	-1.9	-1.1	-1.5	-0.1	-2.0
Hearing difficulty/problems: Yes	1.0	1.5	3.4	1.3	1.1	0.8	1.8	0.6
Current tobacco smoking	1.0	1.6	6.3	-0.3	-0.9	-2.5	-0.5	-0.9
Body mass index (BMI)	1.0	4.2	11.6	-1.7	-1.2	-3.4	-0.2	-2.2
Trunk fat mass	1.0	4.1	6.5	2.5	2.5	1.7	1.5	1.7
Wheeze or whistling in the chest in last year	1.0	1.7	2.9	-1.3	-1.2	-1.5	0.0	-1.7
Hypertension (Self-reported)	1.0	2.8	7.9	-2.2	-0.7	-2.8	0.3	-0.7
Arm fat percentage (left)	1.0	4.1	11.6	-2.2	-1.6	-3.4	0.5	-1.2
Eye problems/disorders: Cataract	1.0	1.2	2.9	-1.7	-1.4	-1.1	0.1	-0.2
Smoking status: Current	1.0	1.5	5.9	0.3	-1.1	-2.4	-0.3	-0.6
Average weekly champagne plus white wine intake	1.0	1.4	2.3	1.2	1.5	1.4	0.4	1.0
High cholesterol (Self-reported)	1.0	1.8	5.0	0.7	1.0	0.0	2.2	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.1	-0.4	-1.3	-1.4	-0.8	-1.2
Alzheimer’s Disease (in mother)	0.9	1.1	2.1	1.1	1.0	0.7	1.5	0.8
Ulcerative Colitis (UC)	0.9	1.7	3.4	-1.8	-0.4	-0.2	1.5	1.7
Prostate Cancer	0.9	1.3	2.5	1.5	0.9	1.6	-0.5	-0.8
HbA1C	0.9	1.0	1.9	0.4	1.4	0.6	1.4	0.7
Heel T-Score	0.9	7.5	16.8	-3.1	-2.5	-4.1	1.5	-1.8
Respiratory disease	0.9	2.1	4.0	-1.6	-1.5	-1.3	-0.2	-2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.5	-0.9	-1.0	-1.9	-0.4	-0.5
Impedance of leg (right)	0.9	4.2	7.9	2.5	1.2	2.8	0.5	2.2
High blood pressure	0.9	2.5	6.5	-2.3	-0.5	-2.6	0.4	-0.7
Alcohol usually taken with meals	0.9	1.4	2.4	1.2	0.5	1.4	1.0	1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.0	0.5	-1.7	-1.3	0.3	-0.8
Medication: Ramipril	0.9	1.1	3.5	-1.9	-0.6	-1.0	0.7	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.9	0.9	-1.3	-0.5	-1.4	-0.8
Blood clot in the leg (DVT)	0.9	1.1	2.7	-1.1	0.4	-1.7	0.9	-0.7
Headache pain in last month	0.9	1.5	2.9	0.9	1.5	1.7	0.9	0.9
Shortness of breath walking on level ground	0.9	1.1	1.8	-1.3	0.0	-1.3	-0.7	-1.2
Medication: Omeprazole	0.9	1.1	1.8	-1.4	-0.7	-1.0	-0.9	-1.2
Medication: Seretide 50 evohaler	0.9	1.1	2.1	-1.4	-0.6	-1.3	-0.1	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.7	-1.3	-1.1	-1.3	-1.3	-0.9
Irritable Bowel Disease (IBD)	0.8	1.8	4.2	-2.0	-1.2	0.5	1.3	1.2
Blood Eosinophil Count	0.8	5.8	11.2	-3.3	-2.1	-2.7	-0.2	-2.4
Medication: Levothyroxine sodium	0.8	1.4	4.3	-2.1	-1.3	-0.7	0.4	-0.3
Impedance of leg (left)	0.8	3.9	7.0	2.5	1.4	2.6	0.6	1.9
Qualifications: A levels/AS levels or equivalent	0.8	1.9	5.0	0.4	0.0	0.6	2.0	2.2
Exposure to tobacco smoke at home	0.8	0.9	3.2	-0.5	-1.8	-0.7	0.1	0.7
Hair/balding pattern: Pattern 4	0.8	2.0	9.2	-3.0	0.4	-0.2	0.7	-0.4
Loud music exposure frequency	0.8	0.9	2.8	-1.7	-0.8	0.2	1.0	0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.7	-1.2	-0.7	-1.3	-0.4	-1.2
High blood pressure (siblings)	0.8	1.2	3.4	-1.8	1.0	-0.5	1.2	0.1
Chest pain or discomfort	0.8	1.1	2.9	-1.2	-1.7	-0.7	0.8	0.5
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.4	1.2	0.9	0.7	-0.8	-1.2
Loneliness, isolation	0.8	1.2	3.2	-0.9	0.6	0.6	1.8	1.0
Ever had bowel cancer screening	0.8	0.9	2.1	-1.0	-1.4	-1.1	0.2	-0.2
Back pain experienced in last month	0.8	1.2	2.6	1.4	1.1	-0.2	-0.4	1.6
Ever taken oral contraceptive pill	0.8	0.9	2.2	0.7	0.8	-0.7	1.5	1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.9	-1.1	-1.4	0.3	-1.2	-0.6
Medication: Bendroflumethiazide	0.8	1.2	3.2	-1.1	0.2	-0.8	1.8	0.9
Ever smoked	0.8	1.4	3.7	1.2	-0.6	-1.9	1.2	0.6
Age started oral contraceptive pill	0.8	1.1	4.0	0.7	0.1	0.9	0.1	2.0
Diastolic blood pressure, automated reading	0.8	2.5	5.2	-2.3	-1.1	-1.5	-0.0	-2.0
Ever depressed for a whole week	0.8	1.0	2.2	0.6	-1.5	-1.3	0.9	-0.0
Myopia	0.8	1.2	2.5	-0.2	-0.5	-1.1	1.6	1.3
Vascular/heart problems diagnosed by doctor	0.8	2.3	6.5	2.0	0.5	2.6	-0.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.7	-1.1	0.6	-1.3	1.2	-0.5
Depressed Affect (Nagel 2018)	0.7	1.5	2.5	0.1	1.1	1.3	1.4	1.6
Hypothyroidism (self reported)	0.7	1.6	3.1	-1.7	-0.9	-1.0	-0.0	-1.8
Supplements: Zinc	0.7	0.7	2.2	0.4	0.7	1.5	-0.8	-0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.6	-0.6	0.8	1.6	-0.1	0.3
Qualifications: CSEs or equivalent	0.7	0.9	2.3	-0.5	-0.6	-0.6	-1.5	-1.1
Multivitamins +/- minerals	0.7	0.8	2.5	0.3	-0.7	0.5	-1.6	-1.0
High blood pressure (mother)	0.7	1.0	2.8	1.0	0.6	0.6	0.4	1.7
Past tobacco smoking	0.7	1.4	2.4	-1.4	0.3	1.6	-1.4	-0.5
Fluid intelligence score	0.7	1.4	2.5	0.6	0.1	-1.5	1.6	1.4
Illnesses of siblings	0.7	1.0	2.5	1.6	-0.7	1.3	-0.3	0.0
Medication: Lansoprazole	0.7	0.7	1.3	-0.6	-1.1	-0.9	-0.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.8	-1.1	-0.9	0.0	-1.3	-1.2
Medication: Aspirin	0.7	0.9	2.8	-0.3	-0.3	0.6	1.1	1.7
Qualifications: nursing, teaching	0.7	1.1	2.7	-0.5	-1.7	-1.2	-1.0	0.1
Commuting to job workplace: Public transport	0.7	0.8	2.2	-0.7	-1.5	-0.6	-0.3	0.9
Medication: Blood pressure	0.7	1.3	3.5	-1.9	-0.8	-0.8	-1.0	-0.8
Medication: Atorvastatin	0.7	0.9	2.5	0.4	-1.6	-1.3	-0.3	0.5
Impedance of whole body	0.7	3.6	7.4	1.4	1.1	2.7	1.3	2.4
Body Mass Index (BMI) (2010)	0.6	0.8	3.5	0.3	-0.3	-1.9	0.6	-0.1
LDL Cholesterol	0.6	0.9	2.1	1.5	0.9	0.2	0.2	1.2
Triglycerides	0.6	1.0	2.9	-0.9	-0.6	-1.7	0.8	-0.1
Smoking Status	0.6	1.5	4.8	1.1	-1.1	-2.2	-0.5	-0.6
Relative age voice broke	0.6	0.9	2.8	0.3	1.0	1.7	-0.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	1.2	0.3	0.8	0.7	0.8
Number of incorrect matches in round	0.6	1.1	3.3	-0.7	-1.8	-1.2	-0.3	-0.1
Nervous feelings	0.6	1.1	2.0	-0.4	-1.4	-0.1	-1.4	-1.2
Number of live births	0.6	0.8	2.5	-1.1	-0.5	-0.2	1.6	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.6	0.5	0.5	1.0	-0.7	-1.2
Medication: Cholesterol lowering	0.6	1.0	2.4	-0.2	-0.8	-1.4	1.6	-0.1
Exposure to tobacco smoke outside home	0.6	0.8	1.7	0.7	1.0	0.4	1.3	0.8
Migraine (self-reported)	0.6	0.7	2.2	-0.6	-0.1	1.5	-0.9	0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.7	-0.1	0.8	1.3	-1.3	0.2
Illnesses of father: Heart disease	0.6	0.9	1.9	-0.5	-0.9	-1.2	1.4	-0.2
Commuting to job workplace: Walk	0.6	0.6	1.2	0.1	-1.1	-0.9	-0.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.9	0.1	0.6	1.7	0.2	-0.3
Asthma (self-reported)	0.6	1.2	2.6	-1.6	-1.2	-0.5	0.4	-1.2
Number of self-reported non-cancer illnesses	0.6	1.1	1.5	-1.0	-1.1	-1.2	-0.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.6	-0.8	-0.7	-0.7	-0.7	-1.3
Neuroticism (Nagel 2018)	0.5	1.1	2.5	1.2	1.0	1.6	0.2	0.7
Schizophrenia vs Biploar Disorder	0.5	0.7	1.3	0.5	1.1	0.8	1.1	0.5
Ovarian Cancer	0.5	0.6	1.1	0.6	0.8	1.0	-1.1	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	1.6	1.3	0.8	0.6	0.5	0.6
Lupus	0.5	0.7	1.6	-0.0	1.2	1.2	0.0	0.8
Cardiovascular Disease	0.5	1.6	3.8	-0.0	1.3	-1.9	1.5	0.4
Lung FEV1/FVC ratio	0.5	2.6	3.6	1.5	1.5	1.9	1.5	1.6
Medication for hormone replacement therapy	0.5	0.6	2.6	-0.7	0.0	-0.2	-1.6	0.1
Vitamin and mineral supplements	0.5	0.7	2.1	-0.3	0.3	-0.6	1.5	0.9
Medication: Metformin	0.5	0.7	1.2	0.1	1.0	0.8	0.9	1.1
Diabetes (father)	0.5	0.6	1.3	1.1	1.1	0.3	0.7	-0.4
Average weekly fortified wine intake	0.5	0.6	1.5	1.2	-0.8	0.7	-0.2	0.4
Maternal smoking around birth	0.5	0.7	2.8	-0.6	0.1	-1.7	0.3	-0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.2	-0.4	-1.0	-1.2	-0.4
Had other major operations	0.5	0.6	2.4	-0.6	-0.2	-0.1	1.5	0.6
Medication: Simvastatin	0.5	0.7	2.6	0.6	0.6	0.5	1.6	0.3
Falls in the last year	0.5	0.7	1.6	-0.8	-1.2	-0.7	-0.9	0.2
Asthma	0.5	1.0	2.4	-1.5	-1.1	-0.4	0.4	-1.1
Prospective memory result	0.5	0.6	1.8	-0.1	-0.3	0.6	-1.3	-0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-1.1	-0.8	-0.7	0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	-1.4	-1.2	-0.8	-0.1	-0.9
Leg fat percentage (right)	0.5	1.8	5.5	-1.0	-0.8	-2.4	0.3	-1.4
Age at first live birth	0.5	0.9	2.8	1.0	-0.1	-0.5	-0.7	-1.7
Eye problems/disorders: None of the above	0.5	0.6	1.5	1.2	0.8	0.5	-0.6	-0.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.2	1.1	1.1	0.8	0.6	0.9
Medication: Allopurinol	0.5	0.7	1.5	0.7	-0.6	-0.8	1.2	0.6
Pulse rate, automated reading	0.5	1.5	3.0	1.1	1.0	1.4	0.6	1.7
Family relationship satisfaction	0.5	0.7	1.4	1.2	0.1	0.8	0.5	1.0
Average weekly red wine intake	0.5	0.7	1.7	0.3	0.7	-0.5	1.3	0.9
Long-standing illness, disability or infirmity	0.5	0.8	1.2	-1.1	-0.8	-1.1	-0.8	-0.7
Friendships satisfaction	0.5	0.6	1.3	1.1	0.5	0.4	0.7	0.8
Wears glasses or contact lenses	0.5	0.6	1.2	-0.8	-1.1	-0.9	0.5	-0.3
Leg fat percentage (left)	0.5	2.0	6.0	-1.0	-0.6	-2.4	0.5	-1.5
Pack years of smoking	0.5	0.7	1.6	-0.5	-0.4	-1.1	0.2	-1.3
Crohns Disease (2017)	0.4	0.9	2.0	-1.0	-1.0	1.4	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.3	0.5	-0.5	-1.5	1.3	0.3
Crohns Disease (2012)	0.4	0.7	2.2	-0.3	-0.9	1.5	0.1	0.6
HDL Cholesterol	0.4	0.7	1.6	-0.5	1.3	0.8	-0.9	-0.5
Neuroticism	0.4	0.9	1.8	0.7	0.9	1.3	0.5	1.1
Average weekly spirits intake	0.4	0.4	1.0	1.0	0.0	0.1	-0.6	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.0	0.8	0.8	-1.1	-0.3
Pack years adult smoking proportion	0.4	0.6	1.5	-0.1	-0.2	-1.2	0.4	-1.2
Age when periods started (menarche)	0.4	0.9	2.2	-0.3	0.5	1.3	-1.5	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	-0.4	0.5	-1.0	1.4	-0.7
Stomach or abdominal pain in last month	0.4	0.4	1.1	0.8	0.4	0.6	-1.0	0.3
Waist circumference	0.4	1.4	3.2	0.5	0.5	-1.8	1.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.1	-1.0	-0.1	-1.5	1.3	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.5	0.2	0.7	-1.1	-0.9
Illnesses of mother	0.4	0.5	1.1	0.9	0.7	1.0	0.2	-0.3
Impedance of arm (left)	0.4	1.9	5.1	-0.2	0.0	1.7	1.2	2.3
Breastfed as a baby	0.4	0.4	1.1	0.2	-0.9	-0.4	-0.2	1.1
Birth weight of first child	0.4	0.8	1.7	-0.6	-0.3	-0.7	-1.2	-1.3
Medication: Paracetamol	0.4	0.6	1.2	-1.1	0.1	-1.1	-0.3	-0.7
Worry too long after embarrassment	0.4	0.7	1.4	-0.1	-1.1	0.6	-1.2	-0.7
Qualifications: College or University degree	0.4	1.3	3.4	1.8	1.1	0.1	1.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	-0.9	-0.6	-0.8	-0.7	0.1
Smoking status: Previous	0.4	0.6	1.5	0.9	0.2	-0.4	1.2	0.8
Mood swings	0.4	0.7	1.7	-0.5	-0.5	0.3	1.3	1.2
Breast cancer (self-reported)	0.4	0.4	0.9	0.4	-0.9	-0.1	-0.9	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.4	0.3	0.7	-0.7	1.2
Hearing aid user	0.4	0.5	1.7	-1.3	-0.3	-0.5	0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.9	1.4	0.1	0.4	-0.6	-0.2
Commuting to job workplace: Cycle	0.4	0.5	1.2	-1.1	-0.8	-0.9	0.1	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	0.2	0.1	0.9	0.1	-1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	-0.1	-0.8	-1.1	-0.8	-0.1
Alcohol drinker status: Previous	0.4	0.5	0.7	-0.8	-0.6	-0.8	0.5	-0.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	-0.0	-0.6	-1.5	1.1	0.7
Worry (Nagel 2018)	0.3	0.5	1.2	0.0	-0.7	0.2	-1.0	-1.1
Breast Cancer	0.3	0.7	1.6	-0.5	-1.2	-1.2	-0.2	-0.5
Fasting Glucose	0.3	0.4	1.4	-1.2	-0.5	-0.3	-0.3	-0.3
Neuroticism (2016)	0.3	0.4	1.7	0.1	0.3	1.3	-0.1	0.6
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.9	-0.4	-0.0	-0.9	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.7	0.7	0.4	0.5	-0.3
Severe depression (siblings)	0.3	0.3	0.7	-0.8	-0.6	0.7	0.5	-0.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.5	0.3	-0.2	-0.1	-0.4	-1.2
Had menopause	0.3	0.4	0.8	-0.7	-0.6	-0.4	-0.9	-0.5
Heart attack	0.3	0.4	0.9	0.0	-0.6	-0.9	-0.9	-0.0
Diabetes (self-reported)	0.3	0.4	0.8	-0.8	-0.7	0.1	-0.9	0.1
Impedance of arm (right)	0.3	1.4	3.6	-0.5	-0.4	1.3	1.1	1.9
Father’s age at death	0.3	0.4	0.9	-0.3	-0.9	0.9	-0.5	0.1
Tense / ‘highly strung’	0.3	0.5	1.5	0.1	-0.7	1.2	-0.4	0.1
Pulse wave peak to peak time	0.3	0.3	0.9	0.5	0.2	1.0	-0.5	0.3
Health satisfaction	0.3	0.4	1.2	0.4	1.1	0.9	0.0	-0.2
Whole body fat mass	0.3	1.1	2.4	1.6	1.3	0.4	0.8	0.4
Age at last live birth	0.3	0.5	1.8	0.1	0.7	0.0	1.3	-0.3
Leg pain on walking	0.3	0.4	0.9	-0.9	0.4	0.4	0.8	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	0.8	-0.4	-0.3	-0.3	0.9
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.3	-0.6	-0.5	-0.4	1.0
Medication for cholesterol	0.3	0.5	1.1	1.0	0.2	-0.2	0.7	-0.8
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.8	0.8	0.4	0.2	-0.4
Blood Red Count	0.2	1.7	4.8	-2.2	-0.7	1.4	0.6	1.0
Blood White Count	0.2	1.2	3.2	-1.3	-0.5	-0.9	-0.4	-1.8
Systolic Blood Pressure	0.2	1.0	3.8	-2.0	-0.1	-1.0	-0.3	-0.6
Systolic blood pressure, automated reading	0.2	0.5	2.0	-1.4	0.2	-0.3	0.1	-0.6
Trunk fat percentage	0.2	1.0	2.1	0.9	1.1	-0.0	1.5	0.8
Townsend deprivation index at recruitment	0.2	0.2	1.0	-1.0	-0.3	-0.3	-0.1	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.8	0.9	0.7	-0.1	0.5	0.6
Neuroticism score	0.2	0.3	0.8	-0.4	-0.3	0.4	0.9	0.7
Pulse rate	0.2	0.3	0.4	0.5	0.6	0.7	0.6	0.2
Length of working week for main job	0.2	0.2	0.5	0.5	0.1	-0.6	0.7	0.1
Pulse wave reflection index	0.2	0.2	0.4	0.2	0.6	-0.4	0.6	-0.5
Birth weight	0.2	0.4	1.8	0.1	0.3	0.3	-1.4	0.4
Body fat percentage	0.2	0.6	1.9	-0.1	-0.0	-1.4	1.0	-0.2
Number of children fathered	0.2	0.2	0.6	0.7	0.0	-0.3	0.3	0.4
Medication: Ibuprofen	0.2	0.3	0.7	0.7	0.5	0.8	-0.1	-0.0
Alcohol intake frequency.	0.2	0.4	1.3	-0.0	0.1	1.1	-0.8	0.5
Medication: Gliclazide	0.2	0.2	0.8	-0.0	-0.3	0.9	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.5	-0.4	-0.4	0.3	-1.2	-0.5
Medication: Paracetamol	0.2	0.4	1.7	-0.4	0.2	-1.3	-0.0	0.0
Alcohol drinker status: Never	0.2	0.2	0.6	-0.7	0.1	-0.4	-0.5	0.2
Irritability	0.2	0.3	1.3	-0.1	0.0	0.4	1.1	0.4
Supplements: Calcium	0.2	0.3	0.4	-0.4	-0.6	0.5	-0.3	-0.6
Leg fat mass (left)	0.2	0.6	1.5	1.2	1.1	-0.3	0.7	-0.1
Major Depression (MDD)	0.1	0.1	0.4	-0.4	-0.2	0.1	-0.1	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.6	-0.1	-0.0	-0.0	0.7	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.6	0.0	0.3	0.2	0.8	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	0.6	0.0	-0.5	0.1	-0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.6	-0.2	0.1	0.1	0.1
Financial difficulties in last 2 years	0.1	0.2	0.4	0.3	0.6	-0.2	0.5	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.1	-0.3	0.3	-0.6	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.4	0.5	-0.1	0.5	-0.0
Arm fat mass (right)	0.1	0.2	0.5	0.4	0.5	-0.7	0.6	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.2	0.2	0.1	0.2	0.3	0.4
Leg fat mass (right)	0.1	0.5	1.3	1.1	0.9	-0.3	0.6	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.4	0.3	-0.6	0.1
Arm fat mass (left)	0.1	0.3	0.5	0.5	0.7	-0.6	0.7	0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.0	-0.6	0.0	-0.1	-0.4
Cholesterol lowering medication	0.1	0.1	0.3	0.1	0.2	0.2	0.2	0.6
Hair Pigment	0.0	0.8	2.7	-1.6	-0.5	-0.7	0.6	0.5
Tanning	0.0	0.3	0.9	-0.9	0.5	-0.3	0.3	0.2
Worrier / anxious feelings	0.0	0.1	0.2	-0.1	-0.4	0.3	0.3	-0.1

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