Best TWAS P=3.98e-12 · Best GWAS P=1.65e-11 conditioned to 0.0229
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HTR1D | 0.11 | 0.07 | enet | 21 | 0.09 | 1.1e-10 | -5.0 | 5.7 | 1.0e-08 | -0.78 | 0.47 | 0.53 | FALSE |
| 2 | GTEx | Brain Cortex | LUZP1 | 0.23 | 0.14 | lasso | 5 | 0.10 | 7.8e-04 | -6.6 | 6.7 | 2.8e-11 | -1.00 | 0.02 | 0.80 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | RP1-184J9.2 | 0.38 | 0.00 | lasso | 11 | 0.00 | 4.3e-01 | -6.4 | 5.3 | 1.1e-07 | -0.54 | 0.04 | 0.32 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | LUZP1 | 0.09 | 0.09 | lasso | 4 | 0.08 | 2.8e-06 | -6.6 | 6.7 | 2.7e-11 | -1.00 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Testis | LUZP1 | 0.17 | 0.09 | lasso | 4 | 0.08 | 2.6e-04 | -6.4 | -6.3 | 2.2e-10 | 0.55 | 0.03 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | HTR1D | 0.10 | 0.07 | enet | 7 | 0.08 | 3.8e-05 | -5.9 | 6.4 | 1.3e-10 | -0.94 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HTR1D | 0.24 | 0.12 | lasso | 4 | 0.12 | 1.2e-05 | -6.5 | 6.9 | 4.0e-12 | -0.76 | 0.02 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HTR1D | 0.19 | 0.12 | enet | 11 | 0.13 | 7.3e-04 | -6.7 | 6.1 | 9.2e-10 | -0.94 | 0.01 | 0.90 | FALSE |