Best TWAS P=6.4e-22 · Best GWAS P=9.89e-22 conditioned to 0.000718
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | 7.1 | 7.7 | 1.7e-14 | 0.63 | 0.90 | 0.10 | FALSE |
| 2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | -5.9 | -7.1 | 1.2e-12 | -0.39 | 0.06 | 0.14 | FALSE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | 9.3 | 9.6 | 6.4e-22 | 0.77 | 0.11 | 0.88 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | 9.3 | 9.6 | 7.2e-22 | 0.81 | 0.08 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | 9.0 | 6.0 | 2.1e-09 | 0.76 | 0.10 | 0.60 | FALSE |