Best TWAS P=7.42e-18 · Best GWAS P=3.22e-13 conditioned to 0.00318
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | RP11-250B2.6 | 0.16 | 0.05 | lasso | 6 | 0.06 | 7.8e-04 | 6.3 | -6.9 | 6.9e-12 | -0.57 | 0.18 | 0.54 | FALSE |
2 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -6.7 | -6.9 | 4.1e-12 | -0.76 | 0.08 | 0.81 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | RP11-250B2.6 | 0.21 | 0.03 | enet | 37 | 0.13 | 4.7e-05 | 5.0 | -6.5 | 6.4e-11 | -0.23 | 0.14 | 0.09 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 4.5 | 7.4 | 1.0e-13 | 0.49 | 0.28 | 0.60 | FALSE |
5 | GTEx | Esophagus Mucosa | RP11-250B2.6 | 0.20 | 0.16 | lasso | 7 | 0.23 | 3.3e-15 | -6.4 | -6.6 | 3.5e-11 | -0.65 | 0.59 | 0.41 | FALSE |
6 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -4.1 | -8.6 | 7.4e-18 | -0.41 | 0.05 | 0.48 | TRUE |
7 | GTEx | Heart Left Ventricle | RP11-250B2.6 | 0.09 | 0.00 | enet | 6 | 0.02 | 2.0e-02 | 6.7 | -6.3 | 3.1e-10 | -0.82 | 0.04 | 0.77 | FALSE |
8 | GTEx | Lung | RP11-250B2.6 | 0.09 | 0.05 | enet | 16 | 0.07 | 5.3e-06 | 4.5 | -6.8 | 1.3e-11 | -0.36 | 0.62 | 0.27 | TRUE |
9 | GTEx | Muscle Skeletal | RP11-250B2.6 | 0.07 | 0.04 | lasso | 5 | 0.04 | 4.2e-05 | 7.0 | -7.2 | 4.2e-13 | -0.94 | 0.02 | 0.98 | FALSE |
10 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -6.4 | -6.2 | 4.5e-10 | -0.88 | 0.04 | 0.94 | FALSE |
11 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 4.5 | 5.9 | 4.1e-09 | 0.46 | 0.97 | 0.03 | FALSE |
12 | METSIM | Adipose | RP11-250B2.6 | 0.04 | 0.04 | lasso | 12 | 0.02 | 1.7e-04 | 6.5 | -5.8 | 7.9e-09 | -0.60 | 0.42 | 0.43 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCKDHB | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.2e-07 | 5.6 | -5.2 | 1.9e-07 | -0.75 | 0.28 | 0.71 | FALSE |