Best TWAS P=1.17e-08 · Best GWAS P=3.4e-09 conditioned to 1.64e-10
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PRMT6 | 0.17 | 0.10 | enet | 6 | 0.11 | 5.1e-09 | 5.2 | -5.3 | 1.3e-07 | -0.09 | 0.26 | 0.74 | FALSE |
2 | GTEx | Colon Transverse | PRMT6 | 0.29 | 0.24 | lasso | 7 | 0.19 | 1.4e-09 | 5.0 | -5.3 | 1.3e-07 | -0.09 | 0.34 | 0.66 | FALSE |
3 | GTEx | Esophagus Mucosa | PRMT6 | 0.33 | 0.23 | lasso | 7 | 0.29 | 1.4e-19 | 5.1 | -5.2 | 2.2e-07 | -0.08 | 0.32 | 0.68 | FALSE |
4 | GTEx | Heart Left Ventricle | PRMT6 | 0.16 | 0.12 | enet | 9 | 0.13 | 2.3e-07 | 5.0 | -5.2 | 2.1e-07 | -0.12 | 0.33 | 0.64 | FALSE |
5 | GTEx | Liver | PRMT6 | 0.60 | 0.52 | lasso | 6 | 0.58 | 1.0e-19 | 5.0 | -5.2 | 1.7e-07 | -0.08 | 0.33 | 0.67 | FALSE |
6 | GTEx | Muscle Skeletal | PRMT6 | 0.32 | 0.16 | enet | 13 | 0.16 | 2.8e-15 | 5.1 | -5.7 | 1.2e-08 | -0.08 | 0.32 | 0.68 | TRUE |
7 | GTEx | Thyroid | PRMT6 | 0.19 | 0.17 | enet | 14 | 0.19 | 1.7e-14 | 5.0 | -5.2 | 1.9e-07 | -0.08 | 0.35 | 0.65 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRMT6 | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.0e-08 | 5.0 | -5.3 | 1.3e-07 | -0.09 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PRMT6 | 0.09 | 0.03 | blup | 36 | 0.07 | 1.8e-04 | 5.0 | -5.2 | 1.9e-07 | -0.06 | 0.01 | 0.91 | FALSE |
10 | The Cancer Genome Atlas | Esophageal Carcinoma | PRMT6 | 0.33 | 0.26 | lasso | 3 | 0.25 | 2.0e-08 | 5.0 | -5.2 | 1.7e-07 | -0.09 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRMT6 | 0.11 | 0.12 | enet | 7 | 0.12 | 2.3e-13 | 5.1 | -5.4 | 8.4e-08 | -0.09 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PRMT6 | 0.09 | 0.08 | blup | 36 | 0.08 | 3.3e-06 | 5.0 | -5.6 | 2.8e-08 | -0.09 | 0.01 | 0.99 | FALSE |