Best TWAS P=1.81e-18 · Best GWAS P=1.13e-25 conditioned to 1.04e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 8.65 | 8.7 | 5.0e-18 | -0.26 | 0.85 | 0.02 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 5.5e-04 | -4.82 | 5.9 | 3.2e-09 | -0.65 | 0.05 | 0.79 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 8.65 | 7.3 | 3.9e-13 | -0.06 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 3.25 | 6.1 | 1.0e-09 | 0.10 | 0.78 | 0.05 | TRUE |
| 5 | GTEx | Liver | METTL15 | 0.18 | 0.05 | lasso | 3 | 0.09 | 1.9e-03 | -0.44 | -6.3 | 2.5e-10 | 0.27 | 0.06 | 0.35 | FALSE |
| 6 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 8.65 | 8.4 | 4.8e-17 | -0.14 | 0.75 | 0.08 | FALSE |
| 7 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 9.13 | -8.8 | 1.8e-18 | 0.17 | 0.30 | 0.42 | TRUE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LIN7C | 0.04 | 0.01 | lasso | 3 | 0.02 | 1.0e-02 | -1.67 | 5.3 | 1.4e-07 | 0.07 | 0.02 | 0.86 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 8.84 | 6.1 | 9.3e-10 | 0.12 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 8.99 | 8.2 | 2.6e-16 | -0.11 | 0.00 | 0.99 | FALSE |