Best TWAS P=1.69e-11 · Best GWAS P=6.26e-54 conditioned to 4.31e-49
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | LEMD3 | 0.14 | 0.05 | lasso | 8 | 0.05 | 1.1e-03 | -4.6 | -6.0 | 1.5e-09 | 0.11 | 0.28 | 0.42 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | RBMS1P1 | 0.17 | 0.03 | lasso | 11 | 0.04 | 7.3e-03 | 9.0 | -6.7 | 1.7e-11 | -0.40 | 0.07 | 0.40 | TRUE |
| 3 | GTEx | Nerve Tibial | LEMD3 | 0.12 | 0.14 | enet | 13 | 0.16 | 2.0e-11 | -4.5 | -5.7 | 9.7e-09 | 0.11 | 0.50 | 0.50 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEMD3 | 0.02 | 0.02 | blup | 36 | 0.02 | 5.9e-03 | -5.7 | -5.3 | 1.5e-07 | 0.12 | 0.01 | 0.82 | FALSE |