Best TWAS P=7.29e-20 · Best GWAS P=1.9e-17 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NOSTRIN | 0.14 | 0.13 | lasso | 4 | 0.12 | 1.9e-14 | -8.5 | 9.1 | 7.3e-20 | -0.97 | 0.00 | 1.00 | TRUE |
2 | GTEx | Adrenal Gland | NOSTRIN | 0.21 | 0.09 | lasso | 4 | 0.09 | 4.1e-04 | 6.6 | 6.6 | 3.6e-11 | -0.40 | 0.45 | 0.18 | FALSE |
3 | GTEx | Lung | NOSTRIN | 0.09 | 0.06 | lasso | 4 | 0.07 | 7.1e-06 | 7.8 | 7.2 | 7.3e-13 | -0.39 | 0.20 | 0.74 | FALSE |
4 | GTEx | Pancreas | NOSTRIN | 0.30 | 0.12 | enet | 17 | 0.08 | 3.3e-04 | -6.2 | 6.3 | 2.3e-10 | -0.47 | 0.26 | 0.65 | FALSE |
5 | GTEx | Stomach | NOSTRIN | 0.15 | 0.04 | enet | 9 | 0.09 | 6.8e-05 | 7.9 | 8.4 | 4.9e-17 | -0.58 | 0.22 | 0.72 | FALSE |
6 | GTEx | Testis | NOSTRIN | 0.43 | 0.17 | enet | 17 | 0.32 | 1.0e-14 | -5.6 | 7.4 | 1.6e-13 | -0.68 | 0.07 | 0.93 | FALSE |
7 | METSIM | Adipose | NOSTRIN | 0.07 | 0.09 | lasso | 6 | 0.08 | 1.6e-12 | 7.9 | 7.8 | 5.5e-15 | -0.59 | 0.25 | 0.75 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NOSTRIN | 0.03 | 0.01 | blup | 55 | 0.02 | 9.5e-05 | -6.0 | 7.0 | 3.0e-12 | -0.37 | 0.02 | 0.94 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | G6PC2 | 0.32 | 0.07 | blup | 29 | 0.06 | 3.8e-04 | -6.2 | -7.6 | 4.1e-14 | 0.79 | 0.02 | 0.78 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | NOSTRIN | 0.25 | 0.01 | blup | 55 | 0.08 | 2.0e-03 | -6.0 | 5.4 | 7.4e-08 | -0.25 | 0.02 | 0.49 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NOSTRIN | 0.09 | 0.03 | enet | 5 | 0.09 | 1.7e-10 | 6.3 | 5.5 | 4.5e-08 | -0.19 | 0.04 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | G6PC2 | 0.47 | 0.23 | enet | 8 | 0.28 | 4.4e-32 | -6.2 | -7.1 | 1.1e-12 | 0.79 | 0.14 | 0.86 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOSTRIN | 0.12 | 0.13 | lasso | 7 | 0.14 | 4.5e-15 | -6.0 | 7.2 | 6.6e-13 | -0.43 | 0.30 | 0.70 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | G6PC2 | 0.56 | 0.13 | blup | 29 | 0.16 | 2.1e-09 | -6.2 | -7.3 | 2.3e-13 | 0.75 | 0.04 | 0.96 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOSTRIN | 0.08 | 0.01 | enet | 6 | 0.04 | 2.1e-05 | 6.7 | 6.9 | 4.5e-12 | -0.32 | 0.00 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NOSTRIN | 0.05 | 0.00 | blup | 55 | 0.01 | 1.1e-02 | -6.0 | 6.9 | 5.1e-12 | -0.38 | 0.01 | 0.79 | FALSE |
17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NOSTRIN | 0.17 | 0.07 | lasso | 2 | 0.08 | 4.3e-04 | 6.3 | 6.8 | 1.4e-11 | -0.44 | 0.01 | 0.97 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOSTRIN | 0.06 | 0.01 | blup | 55 | 0.01 | 2.9e-02 | -5.3 | 5.3 | 9.9e-08 | -0.23 | 0.11 | 0.71 | FALSE |
19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | G6PC2 | 0.22 | 0.01 | enet | 4 | 0.08 | 3.1e-06 | -6.2 | -6.0 | 1.9e-09 | 0.71 | 0.07 | 0.60 | FALSE |
20 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NOSTRIN | 0.27 | 0.04 | lasso | 3 | 0.08 | 2.8e-03 | 7.0 | 6.4 | 1.2e-10 | -0.44 | 0.00 | 0.74 | FALSE |