Best TWAS P=6.07e-18 · Best GWAS P=5e-20 conditioned to 0.00179
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ECE2 | 0.24 | 0.20 | bslmm | 542 | 0.19 | 1.6e-22 | 7.2 | 6.9 | 4.7e-12 | -0.37 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | PSMD2 | 0.13 | 0.09 | lasso | 5 | 0.08 | 1.3e-06 | -5.4 | 5.7 | 1.5e-08 | -0.42 | 0.88 | 0.02 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | ECE2 | 0.38 | 0.03 | enet | 22 | 0.11 | 1.4e-03 | 7.2 | 5.9 | 4.0e-09 | -0.28 | 0.08 | 0.16 | FALSE |
| 4 | GTEx | Pituitary | ECE2 | 0.52 | 0.30 | lasso | 7 | 0.23 | 1.5e-06 | 7.2 | 6.2 | 4.9e-10 | -0.31 | 0.39 | 0.23 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ABCF3 | 0.13 | 0.08 | lasso | 4 | 0.11 | 1.6e-09 | 5.3 | 6.5 | 9.1e-11 | -0.36 | 0.98 | 0.01 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | PSMD2 | 0.13 | 0.14 | lasso | 4 | 0.15 | 1.4e-12 | -5.4 | 5.5 | 3.0e-08 | -0.39 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | PSMD2 | 0.26 | 0.22 | lasso | 5 | 0.24 | 2.4e-77 | -5.4 | 5.2 | 2.1e-07 | -0.39 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | 7.2 | 6.9 | 6.8e-12 | -0.24 | 0.54 | 0.02 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | -8.2 | 8.6 | 6.1e-18 | -0.73 | 0.03 | 0.84 | TRUE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMD2 | 0.05 | 0.00 | enet | 10 | 0.01 | 3.6e-02 | 7.2 | 5.8 | 5.0e-09 | -0.49 | 0.01 | 0.10 | FALSE |
| 11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | 5.2 | -7.7 | 1.7e-14 | 0.43 | 0.03 | 0.33 | TRUE |