TWAS hub - ABCF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0460	0.0230	9.2e-03	0.000	0.011	-0.002	0.006	-0.002	3.4e-01	1.6e-02	7.7e-01	5.8e-02	7.0e-01
2	GTEx	Artery Aorta	0.1670	0.0760	9.4e-03	0.179	NA	0.138	NA	0.146	4.1e-10	NA	5.0e-08	NA	2.0e-08
3	GTEx	Esophagus Mucosa	0.1140	0.0450	4.4e-03	0.100	NA	0.081	NA	0.083	3.2e-07	NA	4.5e-06	NA	3.6e-06
4	GTEx	Muscle Skeletal	0.0993	0.0304	5.3e-05	0.065	NA	0.080	NA	0.090	5.6e-07	NA	3.1e-08	NA	3.7e-09
5	GTEx	Nerve Tibial	0.1250	0.0460	4.9e-03	0.111	NA	0.059	NA	0.090	3.2e-08	NA	5.5e-05	NA	6.1e-07
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1480	0.0510	2.3e-03	0.102	NA	0.087	NA	0.111	3.3e-06	NA	1.6e-05	NA	1.1e-06
7	GTEx	Skin Sun Exposed Lower leg	0.1290	0.0390	6.3e-05	0.077	NA	0.110	NA	0.112	5.5e-07	NA	2.2e-09	NA	1.6e-09
8	METSIM	Adipose	0.1884	0.0423	1.3e-09	0.138	0.081	0.155	0.145	0.126	4.7e-20	4.2e-12	1.8e-22	5.5e-21	2.3e-18
9	TCGA	Breast Invasive Carcinoma	0.0418	0.0211	5.4e-05	0.004	0.016	0.018	NA	0.008	3.7e-02	2.5e-04	1.2e-04	NA	5.8e-03
10	TCGA	Colon Adenocarcinoma	0.0670	0.0420	6.9e-03	-0.002	0.015	0.013	NA	-0.001	4.3e-01	4.4e-02	5.7e-02	NA	3.5e-01
11	TCGA	Liver Hepatocellular Carcinoma	0.0760	0.0490	6.3e-03	0.034	0.064	0.058	NA	0.054	9.6e-03	6.1e-04	1.0e-03	NA	1.6e-03
12	TCGA	Thyroid Carcinoma	0.0530	0.0310	4.2e-04	0.021	0.012	0.006	NA	0.014	3.4e-03	2.4e-02	8.3e-02	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Impedance of leg (left)	7.1	34.5	79.0	3.1	-3.2	-7.2	-4.9	-4.2	-6.6	-8.9	-5.4	-5.5	-6.5	-6.5	-5.8
Mean Putamen Volume	6.4	7.3	18.2	4.3	2.0	-2.8	-2.9	1.6	-3.1	-2.3	-0.7	-2.5	-3.1	-2.9	-2.7
Impedance of leg (right)	6.3	30.5	69.9	2.4	-2.9	-7.0	-4.7	-3.8	-6.2	-8.4	-5.0	-5.2	-5.9	-6.2	-5.6
Impedance of whole body	5.6	28.4	64.2	3.3	-2.3	-6.4	-4.6	-3.1	-6.1	-8.0	-4.3	-4.9	-6.3	-6.3	-5.4
Blood Platelet Count	4.9	57.4	265.7	16.3	-8.3	-4.3	-6.0	-8.8	-3.6	-5.3	-9.2	-8.2	0.1	0.3	-5.4
Impedance of arm (left)	4.3	19.7	41.9	3.1	-0.9	-5.3	-4.0	-1.6	-5.2	-6.5	-2.8	-3.8	-5.9	-5.8	-4.4
Leg fat-free mass (right)	4.1	21.7	52.1	-2.7	2.7	5.8	3.8	3.5	5.0	7.2	4.3	4.0	5.0	5.3	4.5
Leg predicted mass (right)	4.0	21.3	51.4	-2.8	2.6	5.8	3.7	3.5	5.0	7.2	4.3	4.0	5.0	5.2	4.4
Leg fat-free mass (left)	3.9	20.4	48.8	-3.0	2.9	5.5	3.6	3.7	4.8	7.0	4.4	3.9	4.8	5.0	4.2
Leg predicted mass (left)	3.8	19.9	47.7	-3.0	2.8	5.4	3.5	3.6	4.7	6.9	4.3	3.8	4.7	4.9	4.2
Whole body fat-free mass	3.8	21.6	53.9	-2.8	2.4	5.6	3.7	3.2	5.2	7.3	3.7	3.8	5.5	5.6	4.4
Relative age of first facial hair	3.7	7.7	15.8	1.7	0.5	-2.8	-3.4	-0.0	-3.9	-3.6	-0.4	-1.7	-3.2	-4.0	-3.5
Whole body water mass	3.7	21.0	52.5	-2.8	2.3	5.5	3.7	3.1	5.2	7.2	3.6	3.7	5.4	5.5	4.4
Type 2 Diabetes (T2D) (2012)	3.6	4.2	8.9	-0.9	-0.7	2.3	3.0	-0.4	2.6	2.3	-0.1	1.5	2.3	2.7	2.8
Arm predicted mass (left)	3.5	17.7	42.0	-3.2	1.9	4.9	3.5	2.6	4.7	6.5	3.3	3.6	5.0	5.0	4.0
Impedance of arm (right)	3.4	15.7	32.8	2.5	-0.4	-4.8	-3.7	-1.0	-4.6	-5.7	-2.3	-3.4	-5.3	-5.4	-4.0
Trunk predicted mass	3.3	18.7	48.4	-2.2	2.0	5.1	3.4	2.7	5.0	7.0	3.0	3.5	5.5	5.4	4.1
Trunk fat-free mass	3.2	18.6	48.4	-2.2	2.1	5.0	3.3	2.8	4.9	7.0	3.1	3.5	5.5	5.4	4.0
Basal metabolic rate	3.2	17.8	43.6	-3.0	2.4	5.1	3.3	3.2	4.5	6.6	3.7	3.5	4.8	4.9	3.9
Arm fat-free mass (left)	3.2	16.4	40.4	-2.9	1.8	4.7	3.4	2.5	4.7	6.4	3.2	3.3	4.9	4.8	4.0
Primary Biliary Cirrhosis	3.1	4.4	9.4	-0.7	-0.7	2.8	2.4	-0.6	2.6	2.4	0.5	1.9	2.7	3.1	2.4
Arm fat-free mass (right)	3.1	16.0	38.7	-2.9	1.2	4.8	3.4	2.0	4.6	6.2	2.7	3.0	5.0	5.1	3.9
Chest pain or discomfort	3.1	4.5	8.8	-2.0	-0.2	2.8	1.9	0.0	2.2	2.3	2.0	1.9	2.8	3.0	1.9
Arm predicted mass (right)	3.0	15.1	37.1	-2.5	1.2	4.7	3.3	1.9	4.5	6.1	2.5	2.9	4.9	5.1	3.8
Pulse rate, automated reading	2.9	9.4	19.6	2.6	0.9	-4.4	-3.6	0.3	-3.6	-3.7	-1.4	-3.0	-3.0	-3.7	-3.5
Cardiovascular Disease	2.8	9.3	34.5	1.4	4.7	3.1	-0.9	4.9	-0.0	2.8	5.9	1.5	1.5	2.4	-0.4
Type 2 Diabetes (T2D) (2018)	2.8	5.2	12.3	-3.5	-0.6	2.3	2.4	-0.4	2.7	2.5	1.0	1.7	3.1	2.3	2.4
Alzheimer’s Disease (in father)	2.7	2.9	5.5	1.7	-0.2	-2.1	-2.2	-0.5	-2.4	-2.2	0.0	-0.7	-1.6	-1.9	-2.2
Medication: Bendroflumethiazide	2.6	3.9	17.9	-0.5	2.2	2.1	0.5	2.4	0.5	1.8	4.2	2.5	1.1	1.4	0.7
Depression (Nagel 2018)	2.5	3.8	10.2	2.1	0.9	-1.6	-2.9	0.7	-2.1	-1.5	-0.7	-2.9	-1.6	-0.9	-3.2
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	5.9	-1.1	0.6	1.9	1.4	0.8	2.1	2.4	1.6	1.4	2.0	1.8	1.8
High blood pressure	2.5	7.0	28.3	0.1	4.5	1.9	-0.9	4.7	-0.3	2.1	5.3	1.6	0.5	0.9	-0.3
Hypertension (Self-reported)	2.5	6.9	27.2	0.1	4.3	2.2	-0.7	4.5	-0.0	2.4	5.2	1.8	0.9	1.4	-0.1
Diabetes diagnosed by doctor	2.5	4.1	8.0	-2.3	-0.3	1.8	2.5	-0.2	2.6	2.5	0.5	1.6	2.8	2.1	2.4
Mean time to correctly identify matches	2.4	4.6	15.5	-3.9	-2.3	-0.4	3.1	-2.3	2.4	0.5	-1.3	1.7	0.9	-0.1	2.7
Diabetes (self-reported)	2.3	3.6	9.3	-1.5	0.0	1.9	2.2	0.1	2.4	2.5	0.7	1.4	3.1	2.2	2.0
Handedness (chirality/laterality): Left-handed	2.3	2.7	6.0	-2.4	1.4	1.2	2.0	1.6	1.8	2.1	1.1	1.5	1.2	0.7	2.0
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	9.2	-2.1	-3.0	0.6	2.1	-3.0	2.0	0.0	-2.7	0.6	1.1	0.7	1.6
Commuting to job workplace: Car/motor vehicle	2.2	2.5	8.7	0.0	-1.7	1.4	1.1	-1.4	1.9	1.3	-0.6	0.2	2.9	2.5	1.0
Number of self-reported non-cancer illnesses	2.2	3.8	15.4	1.3	2.0	2.6	-0.4	2.2	0.0	1.8	3.9	0.8	1.8	2.4	-0.1
Number of operations (self-reported)	2.2	3.3	6.7	1.8	1.4	-1.9	-2.2	1.1	-2.0	-1.6	0.5	-1.0	-2.4	-2.6	-2.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	7.6	-1.9	0.9	1.8	2.5	1.1	2.1	2.8	0.3	1.9	1.4	1.3	2.5
Medication: Omeprazole	2.1	2.5	8.6	1.4	2.8	0.6	-0.9	2.9	-0.8	0.5	2.9	0.4	-0.8	-0.5	-0.5
Medication: Atorvastatin	2.1	2.6	4.8	0.2	1.7	-1.6	-2.2	1.5	-2.2	-1.0	0.8	-1.1	-1.9	-2.0	-1.7
Depressed Affect (Nagel 2018)	2.0	4.3	9.7	2.7	2.7	-0.7	-3.1	2.5	-2.4	-0.9	1.2	-1.6	-1.2	-0.7	-2.7
Medication: Metformin	2.0	2.8	6.0	-2.0	0.6	1.3	2.0	0.6	2.5	2.2	0.8	1.7	1.7	1.1	2.1
Medication: Simvastatin	2.0	3.0	5.5	0.9	1.8	2.0	0.8	2.0	1.2	2.4	2.0	1.6	2.3	1.8	1.1
High blood pressure (siblings)	2.0	2.9	11.3	0.7	3.3	0.5	-1.4	3.4	-1.1	0.5	2.7	0.3	-0.3	0.1	-1.2
Heart disease (siblings)	2.0	2.5	5.1	-0.4	0.9	1.6	1.4	1.1	1.5	2.2	1.3	1.8	2.1	2.1	1.3
Worry (Nagel 2018)	1.9	4.1	9.1	2.1	1.9	-1.4	-2.9	1.7	-2.8	-1.9	0.5	-1.0	-1.7	-1.7	-3.0
Ulcerative Colitis	1.9	2.7	7.2	0.8	-1.2	1.3	2.7	-1.0	2.2	1.4	-0.5	2.3	1.0	1.2	2.3
Neuroticism	1.9	4.7	11.7	2.7	2.3	-1.1	-3.4	2.1	-2.7	-1.6	0.7	-1.5	-1.2	-1.3	-3.2
Relative age voice broke	1.9	2.9	6.5	1.5	0.0	-1.5	-2.5	-0.3	-2.5	-2.4	-0.4	-0.8	-1.4	-1.8	-2.5
Heart disease (mother)	1.9	2.3	7.3	-1.0	2.7	1.1	-0.2	2.7	0.1	1.5	2.6	1.1	0.5	0.4	-0.1
Medication: Aspirin	1.9	2.5	5.1	-0.3	1.6	1.9	0.8	1.7	1.0	2.3	2.3	1.2	1.8	1.9	0.9
Medication: Blood pressure	1.9	3.6	14.1	-1.1	2.5	2.3	0.0	2.7	0.5	1.9	3.8	1.7	1.0	1.0	0.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	8.4	1.6	2.4	1.1	-1.1	2.5	-0.9	0.5	2.9	-0.1	-0.4	0.2	-0.8
Heart attack/myocardial infarction (self-reported)	1.9	2.5	4.5	-1.5	0.7	1.6	1.6	0.9	1.5	2.1	1.5	1.7	1.9	1.8	1.6
Reaction Time	1.8	3.4	10.0	-3.2	-2.8	-1.4	1.8	-2.8	1.1	-1.0	-1.9	0.6	-0.5	-1.2	1.4
Average weekly spirits intake	1.8	2.3	8.9	-3.0	-0.4	0.8	2.2	-0.1	2.1	1.3	0.0	1.3	0.7	0.9	2.0
Multivitamins +/- minerals	1.8	2.3	5.0	-0.3	-0.1	1.9	1.2	0.1	2.1	2.2	-0.2	1.3	2.2	2.1	1.5
Qualifications: A levels/AS levels or equivalent	1.8	4.0	9.4	-1.3	0.1	1.4	2.9	0.1	3.0	3.0	-1.1	1.7	1.3	1.5	3.1
Neck or shoulder pain in last month	1.8	2.6	5.3	0.6	0.7	-1.5	-1.9	0.5	-2.1	-2.1	0.2	-1.1	-2.1	-2.3	-2.0
Miserableness	1.8	3.1	12.6	3.6	2.7	1.2	-1.5	2.7	-0.7	0.9	2.0	-0.1	0.3	0.6	-1.0
Risk taking	1.8	2.7	6.5	1.5	-2.2	-1.2	-1.2	-2.4	-1.0	-1.3	-2.6	-2.4	-0.8	-0.8	-0.8
Basal cell carcinoma (self-reported)	1.8	2.1	9.8	0.8	2.2	1.2	0.6	2.1	0.1	0.8	3.1	1.6	-0.7	-0.1	0.5
Fasting Glucose	1.7	2.0	4.3	0.4	1.2	-1.8	-1.9	1.2	-2.1	-1.2	0.7	-0.5	-1.1	-1.8	-1.9
Frequency of depressed mood in last 2 weeks	1.7	2.4	7.2	2.2	0.3	-0.9	-2.7	0.2	-1.6	-1.1	-0.5	-2.5	-0.5	-0.1	-2.2
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	6.7	1.5	0.0	-2.0	-2.6	-0.2	-1.8	-1.9	-1.2	-1.8	-0.7	-1.1	-2.5
Weight	1.7	8.4	17.8	-3.6	2.4	3.3	2.0	3.1	2.6	4.2	3.3	2.2	2.4	2.5	2.4
Loud music exposure frequency	1.7	1.9	3.7	-1.8	0.5	1.9	1.5	0.8	1.7	1.7	0.9	1.0	1.0	1.3	1.6
Medication for pain relief, constipation, heartburn	1.7	3.0	6.6	-2.1	-1.9	-2.0	0.9	-1.9	0.1	-1.4	-2.6	-0.3	-1.9	-2.5	0.9
Comparative height size at age 10	1.7	9.2	18.1	-1.7	-0.2	3.4	3.3	0.3	4.0	4.3	0.9	2.4	4.2	3.9	3.4
Smoking status: Previous	1.7	2.6	6.9	2.6	0.9	2.4	-0.7	1.1	-0.3	1.5	2.1	0.3	1.9	2.1	-0.5
Supplements: Fish oil (including cod liver oil)	1.7	2.2	4.3	-1.4	-1.1	1.7	1.4	-0.8	1.9	1.4	-0.5	1.1	2.0	2.1	1.4
Average weekly beer plus cider intake	1.7	2.4	6.4	-0.1	1.2	-1.2	-2.2	1.1	-2.5	-1.7	0.5	-1.7	-1.6	-0.9	-2.1
Blood White Count	1.6	11.6	41.3	6.4	-1.2	-2.8	-4.3	-1.6	-3.2	-3.4	-2.1	-4.5	-1.8	-1.7	-3.9
Maternal smoking around birth	1.6	2.3	5.7	1.3	0.3	-1.1	-2.4	0.3	-1.9	-1.7	-0.5	-1.8	-1.8	-1.4	-1.8
Taking other prescription medications	1.6	2.5	7.8	1.9	2.1	0.3	-1.6	2.1	-1.7	-0.4	2.8	0.3	-0.4	-1.2	-1.5
Nervous feelings	1.6	3.1	6.1	1.5	2.2	-0.7	-2.3	2.3	-2.3	-1.2	1.2	-0.9	-1.5	-1.2	-2.5
Heart attack	1.6	2.1	3.6	-1.9	0.4	1.2	1.6	0.7	1.5	1.9	1.3	1.5	1.7	1.5	1.5
Pulse wave Arterial Stiffness index	1.6	1.9	4.5	1.7	0.7	-1.4	-2.1	0.5	-1.6	-1.4	0.4	-1.2	-0.9	-0.9	-2.1
Pulse wave peak to peak time	1.6	1.9	4.5	-1.7	-0.6	1.4	2.1	-0.4	1.7	1.5	-0.4	1.2	0.9	1.0	2.1
Medication: Aspirin	1.6	2.1	5.6	0.4	1.7	1.7	0.5	1.8	0.7	2.0	2.4	1.2	1.3	1.7	0.7
Average weekly red wine intake	1.6	2.4	10.2	0.4	0.7	-2.3	-0.6	0.4	-1.1	-1.2	-0.6	-0.6	-3.2	-2.9	-0.4
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.6	0.6	0.0	-1.8	-1.9	-0.2	-1.3	-1.8	-0.7	-0.7	-1.4	-1.9	-1.7
Waist Hip Ratio (WHR)	1.5	6.9	17.9	3.2	0.2	-2.2	-4.2	-0.2	-3.6	-3.1	-1.5	-2.5	-1.3	-1.1	-3.9
Body mass index (BMI)	1.5	6.2	17.7	-4.2	2.3	2.4	1.5	2.9	1.8	3.0	3.3	2.1	1.3	1.4	1.8
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.6	0.7	0.7	-1.8	-1.6	0.7	-1.7	-1.6	0.9	-0.8	-1.2	-1.9	-1.9
Medication for cholesterol	1.5	2.2	7.6	0.1	-1.8	-1.8	-0.1	-1.9	-0.4	-1.6	-2.8	-1.9	-1.4	-1.0	-0.3
Illnesses of father: None of the above (group 1)	1.5	1.8	3.7	-1.2	0.1	1.9	1.6	0.4	1.9	1.9	0.4	1.0	1.2	1.3	1.6
Vascular/heart problems diagnosed by doctor	1.5	4.2	17.1	-0.2	-3.7	-1.2	0.8	-3.8	0.5	-1.5	-4.1	-0.7	0.0	-0.4	0.3
Neuroticism (2016)	1.4	2.1	7.7	0.9	2.8	-0.2	-1.4	2.7	-0.7	0.1	1.8	-0.1	-0.7	-1.3	-1.0
Blood Red Count	1.4	13.3	27.1	-4.6	1.1	3.4	5.2	1.6	4.2	4.8	2.2	3.6	2.8	2.5	4.9
Supplements: Zinc	1.4	1.6	6.1	2.5	1.7	-0.1	-1.6	1.8	-1.1	0.3	0.1	-1.2	-0.3	-0.1	-1.2
Hand grip strength (right)	1.4	3.9	9.9	2.1	1.7	3.1	0.5	1.9	1.0	2.7	1.9	0.7	2.2	2.9	0.7
Hayfever, allergic rhinitis or eczema	1.4	3.1	8.8	2.9	3.0	-0.4	-1.4	2.6	-1.6	0.0	2.0	0.9	-0.9	-1.2	-1.0
Past tobacco smoking	1.4	2.6	5.9	-2.4	-1.4	-2.4	0.9	-1.5	0.3	-1.5	-2.3	-0.2	-1.6	-2.0	0.5
Neuroticism score	1.4	2.9	8.1	2.3	1.9	-0.4	-2.8	1.7	-2.1	-1.0	0.9	-1.3	-0.6	-0.7	-2.5
Lung cancer (father)	1.4	1.6	5.0	0.3	0.2	2.0	1.0	0.3	1.4	1.6	0.9	0.3	1.5	2.2	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	6.9	1.5	2.2	1.7	-0.5	2.3	-0.4	1.0	2.6	1.4	0.1	0.7	-0.5
Worry too long after embarrassment	1.4	2.4	6.2	1.1	2.0	0.3	-2.5	2.0	-1.9	-0.6	0.8	-1.5	-0.2	-0.0	-2.4
Neuroticism (Nagel 2018)	1.3	3.1	7.1	1.7	2.5	-0.4	-2.7	2.4	-2.1	-0.8	1.0	-1.1	-0.7	-0.5	-2.5
Prostate Cancer	1.3	1.8	4.8	2.1	0.7	-0.7	-2.2	0.7	-1.8	-1.4	0.0	-1.2	0.0	-0.2	-2.2
Age at First Birth	1.3	1.8	3.7	0.6	0.0	-1.5	-1.5	-0.3	-1.8	-1.5	-0.7	-1.9	-1.6	-1.7	-1.5
Triglycerides	1.3	2.1	5.8	-0.5	-1.2	1.9	1.4	-1.0	1.8	1.4	-0.6	0.4	2.1	2.4	1.1
BMI	1.3	7.3	16.0	-4.0	2.9	2.9	1.5	3.5	1.6	3.4	3.8	2.0	1.6	1.6	1.7
Ever had hysterectomy (womb removed)	1.3	1.5	5.3	-0.5	0.2	-1.7	-0.3	0.0	-1.3	-1.5	-0.5	-0.1	-1.9	-2.3	-1.1
Angina	1.3	1.7	3.4	-0.6	-0.3	1.8	1.1	-0.2	1.4	1.7	1.2	1.0	1.8	1.8	1.2
Fed-up feelings	1.3	2.3	7.6	1.5	1.4	0.2	-2.7	1.3	-1.7	-0.5	0.9	-2.1	-0.0	0.6	-2.3
Mouth/teeth dental problems	1.3	1.9	4.0	0.2	0.3	-1.7	-1.4	0.1	-2.0	-1.4	-1.2	-1.9	-1.6	-1.3	-1.7
Illnesses of siblings	1.3	1.8	6.6	0.0	-2.5	-0.7	-0.1	-2.6	-0.1	-1.2	-1.8	-1.3	-0.8	-0.8	0.1
Mouth/teeth dental problems: Dentures	1.3	2.2	4.8	-0.2	-0.2	1.8	1.6	-0.0	1.8	1.8	1.0	2.2	1.6	1.4	1.8
Arm fat mass (right)	1.3	5.2	13.0	-3.6	2.4	2.4	1.1	2.9	1.5	2.7	3.2	1.8	1.1	1.3	1.5
Mouth/teeth dental problems: Loose teeth	1.3	1.6	4.8	2.2	0.8	-1.0	-1.4	0.7	-1.6	-1.2	0.9	-1.3	-1.1	-0.4	-1.6
Medication: Blood pressure	1.3	2.4	10.3	0.8	2.7	0.4	-0.8	2.6	-0.8	0.8	3.2	0.6	-0.2	0.4	-0.6
Knee pain experienced in last month	1.3	2.0	5.5	-0.2	2.1	2.0	-0.0	2.3	0.1	1.4	2.3	0.9	0.7	1.3	0.0
Mineral and other dietary supplements	1.3	1.8	4.7	0.5	1.4	-1.7	-0.9	1.0	-1.7	-1.2	0.3	-0.8	-2.0	-2.2	-1.0
Eye problems/disorders: Glaucoma	1.3	1.5	3.9	0.8	1.1	-1.5	-1.4	1.0	-1.1	-1.0	0.3	-0.9	-1.8	-2.0	-1.0
Age started oral contraceptive pill	1.3	1.7	4.9	-1.4	1.3	0.5	1.5	1.4	1.3	1.4	1.2	2.2	0.8	0.3	1.2
Commuting to job workplace: Cycle	1.3	1.5	3.8	2.0	-0.4	-0.9	-1.9	-0.7	-1.2	-1.5	-0.7	-1.2	-1.2	-0.7	-1.5
Number of treatments/medications taken	1.2	2.1	10.6	1.1	2.1	1.1	-0.8	2.2	-0.9	0.5	3.2	1.0	0.2	0.2	-0.8
Qualifications: None of the above	1.2	2.6	6.6	0.0	-0.5	-1.6	-2.5	-0.4	-2.0	-2.2	0.0	-2.0	-1.1	-1.2	-2.6
Medication: Lansoprazole	1.2	1.4	4.1	-0.9	1.4	1.6	-0.6	1.7	-0.5	0.9	2.0	-0.4	0.8	1.2	-0.7
Angina (self-reported)	1.2	1.5	3.5	-0.3	0.2	1.9	0.9	0.3	1.1	1.7	1.6	0.9	1.7	1.6	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	6.2	1.1	1.4	1.7	-0.4	1.4	-0.3	0.8	2.5	-0.1	0.8	1.2	-0.2
Qualifications: nursing, teaching	1.2	1.8	4.4	0.0	0.3	2.1	1.6	0.5	1.6	1.9	0.3	0.8	1.2	1.8	1.7
Arm fat mass (left)	1.2	4.9	12.5	-3.5	2.3	2.3	1.1	2.9	1.4	2.6	3.2	1.7	0.9	1.1	1.4
High cholesterol (Self-reported)	1.2	2.1	5.6	1.4	2.4	-0.9	-1.7	2.2	-1.5	-0.2	1.7	-0.3	-1.2	-1.2	-1.3
Crohns Disease (2012)	1.1	1.8	4.0	1.0	-2.0	0.5	1.7	-1.9	1.3	0.6	-0.9	0.2	1.8	1.9	0.9
Allergy or Eczema	1.1	3.0	9.9	2.6	3.1	0.2	-0.9	2.9	-1.3	0.5	2.4	1.2	-0.2	-0.5	-0.8
Systolic blood pressure, automated reading	1.1	3.1	11.7	-2.3	2.9	0.7	-0.7	3.1	-0.7	0.8	3.4	0.4	-0.1	-0.2	-0.7
Worrier / anxious feelings	1.1	2.2	9.1	1.1	3.0	-0.1	-1.6	2.9	-0.8	0.4	1.3	0.4	0.3	-0.6	-1.3
Medication: Cholesterol lowering	1.1	1.8	4.3	1.9	2.1	-0.3	-1.7	2.1	-1.2	0.2	1.8	-0.5	-0.4	-0.4	-0.9
Ever smoked	1.1	2.0	5.5	2.4	1.3	2.2	-0.7	1.4	-0.1	1.5	1.5	0.0	1.4	1.8	-0.3
Bipolar Disorder (2018)	1.0	1.6	7.0	2.6	1.7	-0.9	-1.2	1.7	-1.0	0.1	0.3	-0.4	-0.8	-1.1	-1.1
Irritable Bowel Disease (IBD)	1.0	2.5	4.4	1.5	-2.1	1.4	1.9	-1.8	1.8	0.9	-1.3	0.6	1.7	1.8	1.4
Body Mass Index (BMI) (2010)	1.0	1.4	5.5	-1.4	2.2	0.9	0.4	2.3	0.4	1.3	1.2	0.8	-0.0	0.3	0.1
Coronary Artery Disease (CAD)	1.0	1.3	3.3	0.2	0.8	1.2	0.8	0.9	1.2	1.6	1.2	0.0	1.8	1.1	1.1
HDL Cholesterol	1.0	1.7	3.2	1.2	1.3	-1.0	-1.8	1.1	-1.5	-1.1	0.7	-0.9	-1.7	-1.5	-1.4
Systolic Blood Pressure	1.0	5.2	23.6	-1.3	3.6	1.2	-1.7	3.8	-1.5	0.6	4.9	0.6	-0.6	-0.2	-1.2
Smoking Status	1.0	2.3	6.6	1.4	1.1	2.3	-1.0	1.2	-0.2	1.4	1.2	-0.4	2.4	2.6	-1.0
High blood pressure (mother)	1.0	1.4	5.1	0.6	2.3	0.3	-0.3	2.2	-0.0	0.9	2.2	0.9	0.1	0.1	-0.2
Medication: Ramipril	1.0	1.2	3.6	-1.9	1.3	0.5	1.2	1.4	0.7	1.5	0.8	0.8	0.5	0.2	1.2
Hip circumference	1.0	4.1	15.9	-4.0	1.5	1.7	1.7	1.9	1.9	2.6	2.0	1.4	0.8	0.9	2.0
Medication: Amlodipine	1.0	1.3	4.2	-0.8	1.6	0.8	0.1	1.8	0.7	1.6	2.0	0.7	0.5	0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	-0.1	1.2	1.3	0.1	1.4	0.5	1.3	1.3	1.3	1.5	1.6	0.3
Shortness of breath walking on level ground	1.0	1.1	3.7	1.4	0.6	-0.4	-1.9	0.6	-1.3	-1.0	0.9	-0.3	-1.0	-0.7	-1.5
Guilty feelings	1.0	1.6	5.7	0.9	0.3	1.8	-0.6	0.4	0.8	1.0	0.4	-0.9	2.3	2.4	-0.4
Crohns Disease (2017)	0.9	1.9	5.3	0.7	-1.7	1.7	1.2	-1.4	1.3	0.9	-0.4	0.0	2.3	2.3	0.6
Hypothyroidism (self reported)	0.9	2.0	7.1	-0.7	2.6	1.0	0.3	2.7	0.2	0.9	2.5	1.2	0.0	0.3	0.3
Hand grip strength (left)	0.9	2.3	5.6	1.7	1.6	2.4	0.3	1.6	0.6	1.9	2.1	0.6	1.2	1.7	0.4
Alcohol usually taken with meals	0.9	1.5	4.2	1.9	1.0	-1.4	-0.6	0.8	-0.5	-0.5	-0.5	-1.3	-2.0	-1.9	-0.0
Allergy	0.9	2.0	5.9	-2.4	-2.2	-0.4	1.0	-2.1	0.7	-0.4	-2.3	-0.8	-0.1	0.2	0.6
Alcohol intake versus 10 years previously	0.9	1.4	4.1	0.1	0.8	1.5	0.3	0.9	0.5	1.2	2.0	0.2	1.7	1.9	0.3
Illnesses of mother	0.9	1.2	4.5	1.1	-1.7	-0.8	0.2	-1.7	-0.4	-0.8	-2.1	-1.0	0.1	0.2	-0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.3	-0.6	2.4	0.7	0.2	2.5	-0.3	0.4	2.3	1.6	-0.5	-0.2	0.1
Age at first live birth	0.9	1.5	4.6	2.2	-0.6	-1.6	-1.2	-0.8	-0.9	-1.1	-1.1	-1.0	-1.3	-1.3	-1.0
Ever had bowel cancer screening	0.9	1.0	3.7	1.9	1.4	0.9	-0.3	1.4	0.0	0.8	1.0	0.1	1.0	1.0	-0.2
Commuting to job workplace: Walk	0.9	0.9	2.7	-0.4	1.6	-0.7	-1.0	1.4	-0.7	-0.3	0.1	-0.4	-1.3	-1.3	-0.8
Diastolic blood pressure, automated reading	0.9	2.7	9.6	-1.5	2.9	0.1	-1.1	3.1	-1.4	0.1	2.6	-0.0	-0.3	-0.5	-1.3
Supplements: Calcium	0.9	1.0	5.3	2.3	1.4	0.7	-0.5	1.4	-0.5	0.2	0.6	0.6	-0.3	0.2	-0.5
LDL Cholesterol	0.8	1.3	4.5	0.7	-1.9	0.1	-0.3	-1.8	0.0	-0.7	-2.1	-1.6	0.2	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.1	0.9	-0.5	-0.5	-1.7	-0.5	-0.6	-0.6	-0.8	-1.8	0.6	1.0	-1.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	4.5	-0.5	0.6	-1.8	0.1	0.5	-0.3	-0.5	-0.4	0.4	-1.3	-2.1	-0.1
Hair/balding pattern: Pattern 2	0.8	1.1	3.5	1.2	1.8	0.9	0.4	1.9	0.1	1.0	1.2	0.9	0.0	-0.3	0.3
Arm fat percentage (right)	0.8	3.1	12.0	-3.5	2.4	1.1	0.1	2.8	0.1	1.0	2.8	1.0	-0.5	-0.4	0.4
Time employed in main current job	0.8	1.0	3.1	0.8	1.6	0.4	-0.2	1.5	-0.5	0.5	1.8	1.2	0.5	0.1	-0.7
Falls in the last year	0.8	1.1	2.2	-0.1	-0.8	-1.2	-1.2	-0.9	-0.6	-1.3	-0.9	-1.5	-0.9	-1.4	-1.1
Depression (self-reported)	0.8	1.0	2.9	0.9	-0.8	-0.3	-1.7	-0.7	-1.2	-1.1	0.5	-0.9	-0.0	-0.2	-1.7
Headache pain in last month	0.8	1.3	4.3	0.7	2.0	1.0	-0.9	2.1	-0.1	0.8	1.2	-0.7	0.9	1.0	-0.9
Wheeze or whistling in the chest in last year	0.8	1.4	4.6	0.4	-0.1	1.7	-1.6	0.2	-0.3	0.1	1.5	-1.0	1.3	2.1	-1.2
Leg fat mass (right)	0.8	3.0	12.6	-3.5	1.9	1.3	0.6	2.4	0.6	1.6	2.6	1.2	0.4	0.4	0.7
Number of full sisters	0.8	1.0	5.8	2.4	0.6	0.4	-1.2	0.6	-1.2	-0.5	0.8	-0.2	0.4	0.3	-1.2
Back pain experienced in last month	0.8	1.2	3.6	0.6	0.7	0.3	-1.6	0.7	-1.5	-0.7	-0.4	-1.8	-0.0	0.7	-1.9
Osteoporosis (self-reported)	0.8	0.9	3.1	0.6	1.1	1.0	0.6	1.2	0.4	0.6	1.7	1.7	-0.3	-0.4	0.6
Wears glasses or contact lenses	0.8	1.0	3.3	-0.0	1.2	-0.9	-0.9	1.0	-1.0	-0.6	0.2	-0.3	-1.3	-1.8	-1.0
Medication: Paracetamol	0.8	1.2	4.9	0.4	0.4	1.4	0.1	0.4	0.7	1.1	1.1	0.6	2.2	2.1	0.0
Irritability	0.8	1.3	3.8	0.2	0.4	-1.1	-1.4	0.2	-1.9	-1.5	-0.3	-0.8	-1.5	-1.1	-1.5
Vitamin and mineral supplements	0.7	1.0	2.4	0.5	0.6	-1.1	-0.6	0.4	-1.5	-1.2	1.1	-0.5	-1.6	-1.1	-0.9
Diabetes (father)	0.7	0.8	2.7	0.3	0.4	0.9	0.2	0.4	0.9	1.4	0.2	0.5	1.5	1.6	0.7
Stomach or abdominal pain in last month	0.7	0.8	3.8	-2.0	-0.5	0.7	0.2	-0.2	0.7	0.6	0.2	-0.4	1.4	1.5	0.0
Sitting height	0.7	4.9	14.7	0.0	-0.8	2.8	1.6	-0.4	2.5	3.2	-0.6	0.6	3.7	3.8	1.7
Waist circumference	0.7	2.6	7.9	-2.8	2.2	1.3	-0.0	2.6	0.5	1.8	2.2	0.8	0.5	0.5	0.5
Pulse rate	0.7	1.1	2.9	-0.0	-0.2	-1.7	-0.5	-0.4	-1.0	-1.5	-0.9	-1.5	-1.1	-1.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	4.2	2.1	-0.7	0.2	-0.8	-0.8	-0.3	-0.4	-0.5	-0.9	0.8	0.9	-1.0
Tense / ‘highly strung’	0.7	1.2	2.3	1.2	-0.5	-1.1	-1.4	-0.6	-1.2	-1.5	-0.5	-1.0	-0.8	-1.3	-1.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.0	0.9	0.6	-0.5	-1.7	0.5	-1.0	-0.8	1.0	-0.2	-0.1	-0.5	-1.4
Gout (self-reported)	0.7	1.0	3.6	0.0	1.9	-0.2	0.7	1.9	-0.3	0.4	1.0	0.5	-0.9	-1.0	0.5
Exposure to tobacco smoke outside home	0.7	1.0	2.2	-1.2	0.0	1.3	0.8	0.3	1.5	1.0	0.7	0.5	1.0	1.3	1.0
Number of full brothers	0.7	0.8	1.9	-1.4	-0.6	0.6	1.3	-0.4	1.3	1.0	0.0	0.5	0.9	0.7	1.1
Emphysema/chronic bronchitis	0.7	0.8	3.3	-0.9	0.5	1.1	0.6	0.9	0.5	1.1	1.8	0.7	0.7	0.7	0.7
Migraine (self-reported)	0.7	0.8	3.7	1.4	1.9	0.3	-0.1	1.6	-0.5	0.2	0.8	-0.6	-0.5	-0.2	-0.6
Whole body fat mass	0.7	3.0	11.7	-3.4	2.0	1.4	0.7	2.4	0.7	1.7	2.6	1.0	0.2	0.4	0.9
Alcohol intake frequency.	0.7	1.7	3.3	-1.8	0.1	1.3	1.2	0.4	1.3	1.5	1.2	1.8	1.7	1.1	1.0
Family relationship satisfaction	0.7	0.9	3.0	-0.3	0.0	0.5	1.4	0.1	1.5	1.0	0.4	1.3	0.5	0.3	1.7
Supplements: Vitamin C	0.7	0.8	3.7	-0.2	-1.3	-0.8	-0.7	-1.0	0.0	-0.5	-1.9	-1.3	0.1	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.2	2.1	1.2	1.2	-0.9	1.2	-0.1	1.3	0.4	-0.3	1.5	2.0	-0.7
Mood swings	0.7	1.3	3.4	0.8	1.9	0.5	-1.4	1.8	-0.9	0.0	1.7	0.0	0.1	0.1	-1.3
Average weekly champagne plus white wine intake	0.7	1.0	4.6	2.1	-0.8	-0.5	-0.5	-1.0	-0.3	-0.4	-1.9	-0.2	-0.5	-0.9	-0.1
Myopia	0.7	1.1	3.4	0.0	1.7	0.5	-0.8	1.7	-1.4	0.1	1.8	0.5	-0.2	-0.2	-0.8
Leg fat mass (left)	0.7	2.8	11.2	-3.3	1.9	1.4	0.5	2.3	0.5	1.6	2.5	1.2	0.3	0.4	0.7
Bipolar Disorder or Schizophrenia	0.6	1.4	5.6	2.4	1.9	-0.8	-0.5	1.7	-0.3	0.4	0.4	0.3	-1.3	-1.2	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.2	-0.7	0.6	0.2	2.5	0.4	1.0	1.3	0.2	2.2	-0.7	-1.0	2.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.8	-0.6	-1.6	-0.3	1.0	-1.7	0.4	-0.6	-0.4	0.3	-0.3	-0.4	0.8
HbA1C	0.6	0.7	2.4	0.5	0.0	0.1	-1.3	0.1	-1.5	-0.9	-0.2	-0.7	-0.1	0.1	-1.6
Height	0.6	12.1	33.8	1.4	1.5	4.6	2.8	2.0	3.9	5.8	1.9	2.0	4.7	4.5	3.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.0	0.9	1.3	-0.2	0.6	1.4	0.2	0.7	0.5	0.9	-0.6	-0.9	0.8
Medication: Co-codamol	0.6	0.7	2.0	1.3	0.4	0.7	-1.3	0.5	-0.5	-0.3	1.4	0.1	0.2	0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.3	-0.4	0.8	-0.4	-1.2	0.7	-2.1	-1.2	-0.0	-1.0	-1.8	-1.1	-1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	-1.2	-0.9	-0.6	0.2	-0.8	-0.4	-1.1	-0.4	-0.5	-1.3	-1.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.3	-0.8	0.3	-0.1	-1.2	0.4	-2.1	-1.5	-0.3	-1.6	-1.8	-0.7	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.5	-0.2	-0.7	0.9	0.9	-0.6	0.8	0.4	0.8	1.6	0.5	0.7	1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	3.2	1.8	-1.0	-0.2	-0.6	-1.1	-1.0	-0.8	-0.3	-0.8	-0.3	0.1	-0.7
Body fat percentage	0.6	2.2	8.0	-2.8	1.4	-0.5	-0.9	1.6	-1.3	-0.9	1.6	-0.5	-2.0	-1.7	-0.8
Suffer from ‘nerves’	0.6	0.9	2.3	0.3	0.9	0.0	-1.5	1.0	-1.4	-0.6	1.4	-0.2	-0.9	-0.7	-1.2
Leg pain on walking	0.6	0.7	3.1	-0.2	1.7	-0.1	0.3	1.8	0.5	1.0	0.6	0.1	-0.3	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.6	1.1	-0.1	1.4	0.1	-0.0	0.4	0.2	0.6	0.7	1.1	1.6	-0.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.7	1.2	-1.6	0.0	0.1	-1.6	0.6	-0.1	-1.0	-0.1	0.6	0.6	0.2
Arm fat percentage (left)	0.6	2.4	9.9	-3.1	2.1	0.7	-0.3	2.5	-0.4	0.4	2.5	0.4	-1.1	-0.7	-0.0
Medication: Gliclazide	0.6	0.7	2.1	-1.4	0.0	0.3	0.9	0.1	1.3	1.0	0.2	0.9	0.5	0.0	1.0
Illnesses of father: High blood pressure	0.6	0.7	3.3	0.7	1.4	0.7	0.3	1.2	-0.3	0.5	1.8	0.7	0.3	0.4	0.1
Alcohol drinker status: Never	0.6	0.8	2.7	-0.7	1.1	0.3	1.0	1.1	0.2	0.7	1.6	1.4	0.4	-0.2	0.3
Pain experienced in last month	0.6	1.0	2.7	-0.2	-1.1	0.4	1.4	-1.1	1.4	1.0	-0.6	0.9	0.9	0.7	1.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.2	0.2	1.0	1.0	0.4	1.2	0.3	0.9	1.8	0.9	0.5	0.6	0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	2.5	-0.1	-1.5	-1.0	0.0	-1.6	-0.5	-1.1	-0.1	0.1	-0.7	-1.0	-0.1
Ulcerative Colitis (UC)	0.5	1.0	2.7	1.6	-1.1	0.5	1.3	-0.9	1.1	0.4	-1.1	0.8	0.4	0.7	1.1
Blood Eosinophil Count	0.5	4.0	29.3	5.4	2.0	0.7	-1.5	1.8	-0.1	1.1	2.2	0.7	0.8	0.8	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	0.3	0.7	1.0	-1.2	0.8	-0.7	-0.1	1.2	-0.5	0.5	0.9	-1.2
Pack years adult smoking proportion	0.5	0.7	1.6	0.1	-0.8	0.3	-1.0	-0.7	-0.3	-0.7	-0.5	-1.3	1.2	1.2	-1.2
Trunk fat percentage	0.5	2.2	6.6	-2.6	1.5	-0.4	-0.8	1.8	-1.3	-0.9	1.7	-0.5	-2.0	-1.7	-0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.4	1.2	-0.0	-0.7	1.3	-0.9	-0.2	1.1	-0.1	-0.5	-0.6	-0.7
Medication: Atenolol	0.5	0.6	2.9	0.7	0.7	0.9	-0.3	0.7	-0.5	0.4	1.7	0.6	0.2	0.6	-0.5
Trunk fat mass	0.5	2.2	8.4	-2.9	1.9	1.1	0.2	2.3	0.2	1.1	2.5	0.6	-0.2	0.1	0.3
Number of incorrect matches in round	0.5	0.8	2.1	1.4	-0.1	-1.1	-1.2	-0.3	-0.8	-1.0	-0.7	-0.9	-0.4	-0.8	-1.1
Had menopause	0.5	0.7	1.9	0.2	1.2	0.5	1.0	1.4	0.4	0.9	1.1	1.1	0.3	-0.1	0.5
Had other major operations	0.5	0.7	2.3	1.5	0.7	-0.9	-0.3	0.6	-0.3	-0.4	0.6	0.4	-1.0	-1.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.4	0.9	1.0	0.8	-0.7	1.1	0.0	0.5	1.9	0.3	0.8	0.7	-0.7
Hair/balding pattern: Pattern 3	0.5	0.8	3.3	-1.1	-0.1	0.1	1.2	-0.0	1.2	0.5	-0.1	1.8	0.2	0.4	1.4
Length of working week for main job	0.5	0.6	2.1	-0.7	-0.4	1.0	0.3	-0.2	1.0	0.7	0.1	0.2	1.1	1.5	0.4
Exposure to tobacco smoke at home	0.5	0.5	1.8	-0.9	0.6	-0.2	-0.5	0.5	-0.8	-0.5	1.4	-0.6	-1.1	-0.4	-0.4
Breastfed as a baby	0.5	0.7	3.9	0.1	-1.1	-0.5	0.1	-1.1	0.4	-0.6	-2.0	-0.6	-0.5	-0.4	0.2
Blood clot in the leg (DVT)	0.5	0.6	2.8	0.2	0.9	0.9	0.3	1.0	0.3	0.8	1.7	0.7	0.5	0.5	0.2
Medication: Paracetamol	0.5	0.9	3.4	0.9	0.3	1.0	-0.4	0.2	0.1	0.6	1.0	0.1	1.8	1.8	-0.4
Leg fat percentage (right)	0.5	1.9	9.4	-3.1	1.0	-0.8	-0.9	1.3	-1.3	-1.0	1.2	-0.3	-1.4	-1.6	-1.0
Qualifications: College or University degree	0.5	1.5	3.4	0.1	-0.0	0.6	1.7	-0.3	1.6	1.8	-1.8	0.4	1.1	0.9	1.8
Eye problems/disorders: None of the above	0.5	0.6	1.4	-1.0	-1.2	1.1	0.3	-1.2	0.3	0.0	0.1	0.7	0.4	1.1	0.5
Medication: Ibuprofen	0.5	0.6	2.3	1.5	-0.6	0.6	-0.6	-0.6	-0.0	0.0	0.1	-0.3	1.2	1.3	-0.9
Long-standing illness, disability or infirmity	0.5	0.7	1.9	0.3	0.9	0.2	-0.8	1.0	-1.3	-0.4	1.3	-0.2	-0.3	-0.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	0.7	1.4	-0.0	-1.1	1.3	-0.5	0.1	0.7	-0.4	-0.1	0.3	-1.1
Commuting to job workplace: Public transport	0.5	0.6	2.1	-1.4	0.9	-0.6	0.8	0.7	0.7	0.4	-0.4	0.3	-0.5	-0.7	1.0
Medication: Lisinopril	0.5	0.7	2.5	-0.0	1.6	0.2	-0.2	1.5	-0.0	0.5	1.3	0.9	0.2	-0.4	0.1
Leg fat percentage (left)	0.5	1.9	7.8	-2.8	0.9	-0.7	-1.0	1.1	-1.5	-1.2	1.1	-0.4	-1.7	-1.6	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.7	0.1	0.1	1.6	-0.1	0.0	0.4	0.4	1.2	0.6	0.8	1.1	0.2
Fractured/broken bones in last 5 years	0.5	0.6	1.6	-0.9	-0.5	1.1	0.4	-0.5	1.1	0.7	0.4	0.1	0.9	1.2	0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.8	0.1	-0.2	0.8	1.9	-0.3	0.9	1.2	-0.0	1.4	0.5	0.3	1.9
Breast Cancer	0.4	0.9	1.9	-0.3	-0.7	-0.9	-1.0	-0.7	-0.9	-1.4	-1.2	-1.4	-0.7	-0.2	-1.1
Ovarian Cancer	0.4	0.5	1.3	-0.5	-1.1	-0.4	0.8	-1.1	0.0	-0.5	-0.1	0.8	-0.2	-1.0	0.4
Lupus	0.4	0.6	3.6	-0.3	0.9	1.1	-0.4	0.9	-0.4	0.2	1.9	0.7	-0.2	0.2	-0.2
Townsend deprivation index at recruitment	0.4	0.6	2.5	-0.2	-0.2	1.3	0.0	-0.2	0.3	0.4	0.7	-0.0	1.1	1.6	0.2
Current tobacco smoking	0.4	0.7	3.1	0.5	1.8	0.1	-0.6	1.6	-0.3	0.1	0.7	-0.3	-0.1	-0.1	-0.8
Average weekly fortified wine intake	0.4	0.5	2.8	-0.1	-1.0	-0.4	0.4	-0.9	0.7	-0.2	-1.7	-0.7	-0.0	0.1	0.4
Hearing difficulty/problems with background noise	0.4	0.6	4.6	-2.1	-1.1	-0.2	0.5	-1.0	-0.0	-0.2	-0.1	-0.0	-0.4	0.0	0.3
Financial difficulties in last 2 years	0.4	0.5	1.2	-0.6	0.8	-1.0	-0.6	0.7	-0.9	-0.6	0.1	0.1	-0.8	-1.1	-0.6
Noisy workplace	0.4	0.5	1.7	0.3	0.4	0.3	-1.0	0.4	-1.1	-0.7	1.0	-0.5	-0.3	0.5	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	3.5	-1.9	0.0	-0.4	0.6	-0.1	0.1	-0.1	-0.4	0.5	-0.4	-0.6	0.4
Standing height	0.4	3.7	10.5	0.9	0.4	2.3	1.4	0.6	2.1	3.2	0.5	0.6	2.9	2.9	1.5
Hair/balding pattern: Pattern 4	0.4	1.0	8.5	-2.9	-0.1	0.3	0.3	0.1	0.4	0.7	0.5	-0.6	1.0	0.6	0.2
Birth weight of first child	0.4	0.8	2.3	-1.5	-1.1	0.2	1.1	-1.1	0.8	0.5	-0.9	0.2	0.6	0.4	1.1
Peak expiratory flow (PEF)	0.4	1.0	3.0	1.7	1.7	0.3	-0.8	1.7	-0.3	1.1	0.6	0.1	0.3	0.5	-0.6
Medication: Allopurinol	0.4	0.5	1.7	1.1	1.3	-0.5	0.2	1.3	-0.5	0.2	0.6	0.4	-0.6	-0.2	0.1
Had major operations	0.4	0.4	0.9	0.6	0.1	-0.4	-0.8	-0.0	-0.9	-0.7	0.1	-0.4	-0.9	-1.0	-0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.7	-1.2	-0.3	-0.6	0.5	-0.3	0.3	-0.3	-1.3	0.1	-0.4	-1.0	0.3
Loneliness, isolation	0.4	0.5	1.6	0.7	0.7	-0.2	-1.3	0.6	-0.9	-0.7	0.5	-0.9	-0.5	-0.4	-0.9
Eye problems/disorders: Cataract	0.4	0.4	1.7	0.8	1.2	-0.1	0.3	1.3	0.1	0.7	-0.0	-0.4	0.7	0.2	-0.2
Smoking status: Current	0.4	0.7	2.8	0.5	1.7	-0.1	-0.8	1.5	-0.6	-0.2	0.7	-0.5	-0.5	-0.3	-1.0
Ever taken oral contraceptive pill	0.4	0.4	1.2	1.1	-0.0	0.4	-1.1	-0.1	-0.9	-0.4	-0.2	-0.5	0.2	0.6	-0.9
Mother’s age at death	0.4	0.5	1.5	0.8	1.1	0.1	1.2	0.8	0.7	0.8	0.0	0.8	0.4	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	3.0	0.1	1.0	0.5	-0.3	1.0	-0.1	0.3	1.7	0.4	-0.1	-0.2	-0.2
Ever depressed for a whole week	0.4	0.5	2.7	-0.1	-0.3	0.7	0.5	-0.3	0.7	0.3	1.0	1.6	0.7	0.7	0.6
Pack years of smoking	0.4	0.6	1.9	-0.2	-0.8	0.6	-0.7	-0.7	-0.1	-0.4	-0.2	-1.0	1.4	1.3	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	-1.3	0.8	-0.1	0.4	0.7	0.2	0.2	0.2	-0.2	-1.0	-0.7	0.3
Major Depression (MDD)	0.3	0.4	1.1	0.4	0.5	1.0	-0.4	0.4	0.1	0.8	0.9	0.3	0.3	0.9	0.3
Rheumatoid Arthritis	0.3	0.4	3.4	1.9	-0.1	-0.1	-0.7	-0.1	-0.6	-0.4	0.5	0.1	-0.1	-0.2	-0.6
Respiratory disease	0.3	0.7	2.4	0.4	-1.1	0.6	0.4	-0.9	1.1	0.6	0.1	0.2	1.5	1.4	0.6
Severe depression (siblings)	0.3	0.3	1.4	0.5	-0.1	0.6	0.3	0.0	0.3	0.3	1.0	1.2	0.2	-0.0	0.2
Age when periods started (menarche)	0.3	0.7	3.1	0.7	-0.8	0.8	-0.4	-0.9	-0.1	0.3	-0.2	-0.4	1.4	1.8	-0.4
Supplements: Glucosamine	0.3	0.4	2.3	1.5	-0.1	0.2	-0.7	-0.0	0.0	0.0	-0.3	-1.2	0.3	0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.2	0.4	-0.6	-0.7	0.3	-0.6	-0.7	0.1	-0.4	-0.9	-0.6	-0.6
Forced vital capacity (FVC)	0.3	1.3	3.6	1.8	0.8	1.0	0.7	0.9	0.8	1.9	0.4	0.9	1.2	1.4	0.7
Pain all over the body in last month	0.3	0.3	1.5	-0.0	0.2	-0.4	-0.3	0.1	-0.3	-0.6	0.7	0.5	-0.4	-1.2	-0.4
Fluid intelligence score	0.3	0.7	1.9	-0.3	1.1	-0.1	1.2	1.0	0.2	0.9	0.3	1.4	-0.2	-0.7	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.5	1.6	1.2	0.7	0.4	1.2	0.4	1.6	0.4	0.7	0.5	0.8	0.5
Happiness	0.3	0.3	1.0	-1.0	-0.4	0.3	0.5	-0.3	1.0	0.3	0.1	0.7	0.5	0.3	0.7
Prospective memory result	0.3	0.3	1.0	-0.0	0.2	1.0	0.4	0.2	0.3	0.2	1.0	0.7	0.6	0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.3	0.7	2.1	0.0	0.0	2.1	-0.1	1.2	0.6	0.6	0.0	0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	0.9	-0.1	1.0	0.4	-0.1	0.5	0.6	0.8	0.5	0.5	0.8	0.6
Glaucoma (self-reported)	0.3	0.4	1.7	-0.1	0.6	-0.7	-0.4	0.7	-0.3	-0.4	0.5	-0.1	-1.0	-1.3	-0.1
Birth weight	0.3	0.8	2.2	-1.1	0.3	0.5	1.3	0.4	0.9	1.5	0.1	1.0	0.3	0.0	1.3
Forced vital capacity (FVC), Best measure	0.3	1.2	3.3	0.6	1.7	0.7	0.5	1.8	0.5	1.8	0.8	1.0	0.7	1.0	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.1	-0.5	0.7	0.8	-0.5	0.7	0.8	-0.4	0.6	0.8	0.5	0.7
Health satisfaction	0.3	0.4	2.1	-1.4	0.4	-0.3	-0.8	0.5	-0.5	-0.5	0.4	-0.6	-0.4	-0.2	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.2	1.1	-0.5	0.4	-0.5	-0.3	-0.4	-0.3	-0.3	-0.8	-0.1	0.9	-0.5
Overall health rating	0.3	0.7	2.8	-1.5	0.6	0.1	-0.8	0.9	-0.6	-0.4	1.7	-0.4	-0.4	-0.3	-0.9
Age at last live birth	0.3	0.4	1.0	1.0	-0.7	-0.7	-0.1	-1.0	-0.4	-0.4	-0.8	-0.1	-0.5	-0.5	-0.2
Illnesses of father: Heart disease	0.3	0.5	1.5	-0.0	-0.2	-1.2	-0.6	-0.1	-0.7	-0.7	-0.7	-1.1	-0.8	-0.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	0.5	-0.5	-0.3	-1.0	-0.5	-0.6	-0.7	0.1	-0.6	-0.1	0.0	-0.9
Breast cancer (self-reported)	0.3	0.4	1.4	-0.1	0.6	0.9	0.2	0.7	0.5	0.8	0.0	0.2	1.2	0.8	0.3
Hearing aid user	0.3	0.4	1.3	0.3	0.1	-0.6	-0.9	0.1	-0.6	-0.6	-0.9	-0.6	0.3	-0.3	-1.1
Unable to work because of sickness or disability	0.3	0.4	1.3	-0.2	-1.0	0.5	0.4	-1.0	0.4	-0.3	0.6	1.1	0.2	0.1	0.4
Cholesterol lowering medication	0.3	0.4	1.1	-0.4	1.1	0.3	0.4	1.0	0.0	0.7	0.6	1.0	0.5	-0.2	0.1
Alcohol drinker status: Previous	0.3	0.4	1.3	-0.8	-0.9	-0.6	-0.2	-0.8	-0.4	-0.5	-1.1	0.4	0.1	-0.4	-0.5
Schizophrenia (2018)	0.2	0.4	1.1	0.9	0.5	-0.4	0.4	0.4	0.4	0.2	0.2	0.7	-1.1	-0.7	0.8
Bipolar Disorder (2011)	0.2	0.2	2.4	1.6	0.2	0.0	0.2	0.1	-0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.2	0.4	1.8	1.4	0.7	-0.6	-0.0	0.7	0.1	0.3	0.3	-0.1	-0.9	-0.8	0.2
Heel T-Score	0.2	1.7	8.4	-2.9	-1.0	1.2	1.8	-0.7	0.5	0.4	0.3	1.8	0.4	0.2	1.5
Lung FEV1/FVC ratio	0.2	0.9	3.5	-0.9	1.9	-0.2	-0.2	1.9	-0.6	0.4	0.4	-0.7	-0.5	-0.7	-0.6
Lung FVC	0.2	1.1	3.6	0.6	0.4	0.4	1.6	0.4	1.3	1.3	0.5	1.9	0.6	0.1	1.4
Hearing difficulty/problems: Yes	0.2	0.3	1.6	-1.3	-0.2	0.6	0.1	-0.0	0.2	0.7	0.5	0.4	0.3	0.5	0.4
Diabetes (mother)	0.2	0.3	1.2	-1.1	-0.1	0.6	0.4	-0.0	0.7	0.7	0.3	0.3	0.1	0.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.7	0.2	-0.5	-0.5	0.2	-0.1	-0.2	-0.3	-0.6	-0.8	-0.3	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.1	0.6	0.2	-0.6	0.7	-0.5	-0.4	0.6	-0.9	-0.0	0.2	-1.0
Medication: Levothyroxine sodium	0.2	0.4	0.8	-0.2	0.6	-0.4	-0.6	0.7	-0.9	-0.7	0.5	-0.3	-0.8	-0.6	-0.7
Father’s age at death	0.2	0.3	0.8	-0.8	0.2	0.4	0.9	0.3	0.8	0.8	-0.3	-0.1	0.3	0.2	0.8
Number of live births	0.2	0.3	2.7	-1.6	-0.1	-0.1	-0.2	-0.2	-0.1	-0.3	-0.4	0.2	0.0	-0.0	-0.3
Pulse wave reflection index	0.2	0.3	1.1	0.4	-0.1	0.5	-0.5	-0.1	0.1	0.3	0.5	-0.2	0.9	1.0	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	-0.5	0.1	0.6	-0.2	0.2	0.7	0.6	0.2	-0.1	0.9	0.4	0.3
Comparative body size at age 10	0.2	0.5	1.8	0.0	0.8	0.8	0.5	0.9	0.8	1.3	0.5	0.8	0.6	0.4	0.7
Number of children fathered	0.2	0.3	1.3	0.4	-1.0	-0.1	-0.1	-1.2	0.0	-0.6	-0.4	-0.4	0.1	0.2	0.0
Medication: Seretide 50 evohaler	0.2	0.2	0.9	-0.1	0.4	1.0	-0.3	0.5	-0.4	0.2	0.4	-0.0	0.4	0.5	-0.2
Friendships satisfaction	0.2	0.3	0.7	-0.1	0.5	-0.1	0.8	0.5	0.7	0.5	0.4	0.7	-0.0	-0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.6	-0.2	1.2	-0.1	0.8	1.2	0.5	1.0	0.2	0.6	0.3	-0.3	0.7
Chronotype (morning person)	0.1	0.3	1.1	0.0	-0.9	-0.4	-0.1	-0.9	-0.2	-0.0	-1.1	-0.2	-0.1	-0.2	-0.1
Sensitivity / hurt feelings	0.1	0.1	0.4	-0.3	0.6	-0.1	-0.1	0.7	0.5	0.4	0.1	0.5	0.4	-0.1	0.1
Medication for hormone replacement therapy	0.1	0.2	0.7	-0.2	0.8	0.2	-0.3	0.8	-0.3	0.1	0.6	0.1	-0.1	0.0	-0.3
Asthma	0.1	0.2	1.2	1.1	-0.3	0.1	-0.6	-0.1	0.0	-0.2	0.4	-0.1	0.5	0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.2	-0.4	-0.3	0.2	-0.4	0.6	-0.2	-0.1	0.2	0.5	0.1	0.1
Asthma (self-reported)	0.1	0.3	1.4	1.2	-0.1	0.5	-0.4	0.1	0.1	0.1	0.6	0.2	0.7	0.8	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.7	-0.7	-0.3	-0.4	0.9	-0.1	0.0	0.0	0.3	-0.0	-0.1	0.1	0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.2	-0.3	-0.5	-0.2	-0.4	0.4	-0.2	0.1	0.1	0.2	-0.2	0.1
Hair Pigment	0.0	0.6	5.2	-2.3	-0.7	-0.1	-0.2	-0.7	0.4	-0.5	-0.7	-0.2	-0.4	0.3	0.1
Tanning	0.0	0.4	1.3	-0.1	0.0	1.2	-0.2	0.1	0.8	0.8	0.7	0.6	0.8	1.0	0.4

Hub : Genes

ABCF3

Models

Trait associations