Best TWAS P=9.17e-08 · Best GWAS P=1.07e-08 conditioned to 0.0363
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | HMGB1 | 0.26 | 0.02 | lasso | 6 | 0.03 | 9.1e-03 | -5.7 | 5.3 | 9.2e-08 | -0.90 | 0.00 | 0.97 | TRUE |
| 2 | GTEx | Muscle Skeletal | HMGB1 | 0.21 | 0.05 | lasso | 6 | 0.08 | 7.1e-08 | -4.8 | 5.1 | 3.0e-07 | -0.74 | 0.03 | 0.96 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HMGB1 | 0.08 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | -5.2 | 5.2 | 2.3e-07 | -0.78 | 0.02 | 0.96 | FALSE |