Hub : Genes

HMGB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2670	0.0820	0.00210	0.016	NA	0.060	NA	0.025	4.3e-02	NA	3.3e-04	NA	1.5e-02
2	GTEx	Breast Mammary Tissue	0.2570	0.0790	0.00170	0.021	NA	0.002	NA	0.032	3.0e-02	NA	2.4e-01	NA	9.1e-03
3	GTEx	Muscle Skeletal	0.2078	0.0548	0.00013	0.053	NA	0.066	NA	0.075	6.4e-06	NA	4.4e-07	NA	7.1e-08
4	GTEx	Small Intestine Terminal Ileum	0.5780	0.1340	0.00220	0.173	NA	-0.011	NA	0.040	1.1e-04	NA	6.9e-01	NA	4.6e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0778	0.0313	0.00220	0.036	0.026	0.025	NA	0.035	5.8e-05	0.00051	7.0e-04	NA	6.9e-05
6	TCGA	Pheochromocytoma and Paraganglioma	0.2000	0.0810	0.00880	0.003	0.024	-0.006	NA	0.000	2.4e-01	0.03900	7.1e-01	NA	3.2e-01
7	TCGA	Prostate Adenocarcinoma	0.0959	0.0340	0.00015	0.070	0.027	0.049	NA	0.057	8.5e-08	0.00066	7.3e-06	NA	1.4e-06
8	TCGA	Thyroid Carcinoma	0.0730	0.0280	0.00130	0.057	0.027	0.030	NA	0.050	2.8e-06	0.00110	6.4e-04	NA	1.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.6	0.9	2.0	-0.7	-1.1	-1.4	-0.2	-1.1	-0.3	-1.1	-1.0
Bipolar Disorder or Schizophrenia	1.2	3.0	5.0	-1.7	-2.1	-2.2	-0.6	-2.2	-0.6	-1.8	-1.7
Depressed Affect (Nagel 2018)	1.5	3.2	6.2	-2.1	-2.2	-1.3	-0.0	-2.5	-0.8	-2.0	-1.8
Depression (Nagel 2018)	0.7	1.0	4.2	0.9	-0.9	1.0	-0.5	-0.6	-2.0	-0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.7	-1.2	-1.3	-0.6	1.3	-0.9	-0.1	-0.5	-0.4
Neuroticism (Nagel 2018)	3.0	7.1	12.1	-2.6	-3.1	-2.1	0.6	-3.5	-1.7	-3.3	-3.1
Schizophrenia (2018)	1.0	2.0	3.9	-1.7	-1.6	-1.6	-0.6	-2.0	-0.4	-1.5	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	3.7	0.7	0.4	1.1	-1.9	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	2.4	5.1	7.7	-1.7	-2.8	-1.6	2.5	-2.6	-0.7	-2.7	-2.6
Alzheimer’s Disease (in mother)	0.6	0.7	3.5	-0.1	0.9	0.4	1.9	0.2	0.8	0.4	0.5
Alzheimer’s Disease (in father)	6.0	6.5	10.5	2.6	2.6	2.6	-1.4	3.2	1.9	2.8	2.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	0.6	1.1	0.7	0.4	0.8	1.2	0.8	0.8
Crohns Disease (2017)	0.1	0.3	1.1	-0.9	0.0	-0.2	-1.0	0.2	0.2	0.5	0.6
Irritable Bowel Disease (IBD)	0.2	0.5	2.9	-0.3	-0.1	-0.1	-1.7	0.3	0.3	0.7	0.7
Ulcerative Colitis (UC)	0.4	0.7	4.4	0.1	-0.1	0.3	-2.1	0.3	-0.3	0.6	0.6
Major Depression (MDD)	1.0	1.2	3.7	-1.4	-1.9	0.0	-1.2	-0.8	0.8	-0.8	-0.9
Reaction Time	0.6	1.1	2.2	0.6	0.4	0.9	-1.0	1.3	0.7	1.5	1.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.6	-0.5	-1.2	0.1	0.1	-0.8	-0.9	-0.3	-0.2
Breast Cancer	0.8	1.8	3.2	-0.3	-1.8	-0.9	1.0	-1.7	-0.9	-1.7	-1.7
Ovarian Cancer	0.7	1.0	2.9	-1.1	-1.4	-0.8	-1.7	-0.4	-0.2	-0.7	-0.8
Prostate Cancer	0.4	0.6	2.1	0.2	0.5	1.3	-0.2	0.6	1.4	0.3	0.4
Age at First Birth	0.1	0.1	0.4	0.1	0.3	0.4	-0.1	-0.2	0.1	0.6	0.5
Bipolar Disorder (2011)	0.3	0.3	2.1	-0.4	0.0	0.0	1.5	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.6	3.6	7.1	0.8	1.7	1.8	-0.2	2.4	1.6	2.6	2.7
Coronary Artery Disease (CAD)	0.3	0.3	0.7	0.9	0.3	0.8	-0.4	0.7	0.0	0.5	0.3
Crohns Disease (2012)	0.4	0.6	2.0	-1.4	-0.7	-1.3	-0.6	0.0	0.0	0.0	0.0
Mean Putamen Volume	1.9	2.2	5.2	1.8	2.3	1.4	-0.3	1.7	0.1	1.5	1.4
Fasting Glucose	0.2	0.2	0.9	0.4	-0.1	0.4	-0.4	0.5	0.3	0.9	0.5
HbA1C	0.3	0.3	0.6	-0.6	-0.4	-0.4	0.5	0.6	-0.8	0.6	0.5
HDL Cholesterol	0.3	0.5	1.0	0.2	-0.8	-1.0	-0.1	-0.8	-0.7	-0.6	-0.7
LDL Cholesterol	2.6	4.2	7.5	0.7	1.8	2.4	0.4	2.5	1.8	2.5	2.7
Lupus	0.6	0.9	2.6	1.1	0.5	1.1	-0.5	0.4	1.6	0.8	0.8
Neuroticism (2016)	0.3	0.4	0.9	0.4	0.5	-0.9	-0.4	-0.9	0.2	-0.7	-0.7
Primary Biliary Cirrhosis	1.3	1.9	3.4	-0.6	1.4	0.9	-0.7	1.7	1.3	1.9	1.8
Rheumatoid Arthritis	0.6	0.9	4.1	-0.1	0.4	0.2	-2.0	1.1	0.7	0.7	0.6
Schizophrenia (2014)	1.2	2.6	5.1	-1.8	-1.9	-1.7	-0.1	-2.2	-0.8	-1.7	-1.6
Triglycerides	3.4	5.5	9.4	1.7	3.1	3.0	0.3	2.7	1.0	2.8	2.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.4	0.2	0.1	-0.7	0.9	0.4	0.8	0.6
Ulcerative Colitis	0.1	0.1	0.7	0.8	-0.5	-0.0	-0.3	-0.0	-0.1	0.1	0.1
Blood Eosinophil Count	0.1	0.6	3.0	-1.7	-0.7	-0.5	-0.2	0.1	-0.8	0.2	0.1
Blood Platelet Count	0.0	0.2	0.7	-0.2	0.3	0.5	0.5	0.8	0.3	0.6	0.5
Blood Red Count	1.3	12.9	21.8	4.5	4.7	3.6	-0.8	3.8	1.4	4.0	3.9
Blood White Count	0.7	5.4	9.1	-1.2	2.0	2.7	-1.9	3.0	2.1	2.7	2.6
Heel T-Score	0.3	2.7	6.7	-1.8	-1.3	-2.6	-0.3	-1.3	-1.2	-1.7	-1.8
BMI	5.5	32.0	54.4	3.1	6.9	6.7	-1.6	7.4	3.1	6.7	6.5
Height	0.5	9.1	18.3	-1.6	-3.5	-3.2	1.0	-4.3	-2.6	-3.4	-3.2
Waist Hip Ratio (WHR)	2.8	12.8	23.6	0.9	4.0	4.1	-0.6	4.0	2.4	4.8	4.9
Systolic Blood Pressure	0.3	1.5	3.4	0.4	1.9	1.6	0.6	1.6	1.5	0.8	0.7
Smoking Status	6.1	14.7	23.3	2.7	3.7	4.7	-0.4	4.5	2.8	4.8	4.8
Allergy or Eczema	0.1	0.3	0.7	0.0	-0.8	0.4	0.3	-0.8	-0.6	-0.6	-0.5
Cardiovascular Disease	1.2	3.8	5.5	1.5	2.2	2.3	0.4	1.9	2.2	2.2	2.2
Hypothyroidism (self reported)	0.2	0.5	1.3	0.8	0.3	0.2	0.3	0.8	-0.5	1.1	1.1
Respiratory disease	0.3	0.6	3.2	-0.2	0.4	0.3	-1.2	-0.2	-1.8	0.3	0.4
Type 2 Diabetes (T2D) (2018)	5.6	10.4	17.1	1.9	3.3	3.6	-1.6	4.1	1.8	4.0	4.0
Lung FEV1/FVC ratio	0.5	2.6	6.1	0.5	1.6	2.1	-0.4	2.5	0.9	1.9	1.8
Lung FVC	0.2	1.1	3.7	0.7	0.3	1.3	1.9	0.8	0.4	1.0	0.9
Neuroticism	2.3	5.6	13.1	-1.7	-2.7	-1.9	0.6	-3.6	-1.2	-3.0	-2.8
Chronotype (morning person)	0.5	1.1	3.2	-0.1	1.0	0.9	-1.8	1.2	-0.0	1.2	1.2
Hair Pigment	0.5	14.3	31.1	3.5	3.5	5.6	-1.4	4.1	3.5	3.8	3.7
Tanning	0.0	0.4	1.7	-1.3	0.6	-0.1	0.9	0.7	0.2	0.2	0.2
Hand grip strength (left)	2.0	5.4	10.0	-3.2	-2.3	-2.1	0.2	-2.4	-2.3	-2.4	-2.5
Number of treatments/medications taken	0.5	0.9	1.7	0.4	1.2	0.6	-0.8	1.0	0.5	1.3	1.3
Average weekly spirits intake	0.4	0.5	2.2	-1.5	-0.0	-0.1	-0.8	0.1	-0.3	0.5	0.6
Sensitivity / hurt feelings	2.4	4.2	8.5	-2.4	-1.4	-2.0	1.3	-2.9	-1.5	-2.3	-2.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.9	0.2	-1.0	0.7	-0.2	-0.3	-1.7	-0.6	-0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-0.7	0.1	0.1	0.7	0.0	-0.5	1.0	1.1
Relative age of first facial hair	1.9	3.9	7.0	1.1	-1.9	-1.2	2.2	-2.2	-1.2	-2.5	-2.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	5.4	-1.3	-0.4	-1.1	-2.3	-0.5	-1.0	0.2	0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	4.0	2.0	0.2	1.0	1.4	0.7	-0.1	1.0	1.1
Ever had hysterectomy (womb removed)	0.3	0.3	1.4	1.2	0.2	0.3	-0.5	0.5	-0.5	0.2	0.2
Systolic blood pressure, automated reading	0.6	1.6	3.6	1.2	1.8	1.9	-0.2	1.6	1.0	0.8	0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.4	-0.2	1.2	1.0	0.4	1.1	0.8	0.5	0.5
Angina	4.5	5.8	9.0	1.2	3.0	2.7	-0.0	2.6	2.7	2.7	2.8
Medication for hormone replacement therapy	1.3	1.5	4.8	-0.7	-1.0	-1.0	2.2	-1.0	-1.5	-0.8	-0.8
Vitamin and mineral supplements	2.4	3.3	4.7	1.6	1.7	2.1	1.8	2.0	0.6	2.2	2.1
Supplements: Zinc	3.8	4.2	9.3	-1.2	-0.9	-1.9	0.2	-3.0	-2.0	-2.8	-2.6
Medication: Co-codamol	3.2	3.7	5.9	1.4	1.9	2.3	-0.8	2.2	1.3	2.4	2.4
Medication: Metformin	6.3	8.9	14.7	1.0	3.2	3.6	-1.0	3.8	1.9	3.7	3.8
Diabetes (father)	1.6	2.0	4.9	1.0	1.3	1.7	1.2	1.1	2.2	1.2	1.2
Diabetes (mother)	0.8	1.1	4.7	-2.2	0.6	-0.1	-1.7	0.4	-0.3	0.3	0.3
Severe depression (siblings)	1.6	1.8	9.9	-3.1	-0.7	-1.6	-0.4	-0.9	-0.2	-0.6	-0.6
Pack years adult smoking proportion	0.6	0.8	4.4	-0.0	0.3	0.1	-2.1	0.7	-0.1	0.9	1.0
Impedance of leg (right)	1.0	5.1	8.9	-1.1	-2.5	-3.0	0.2	-2.8	-1.4	-2.7	-2.7
Leg fat-free mass (left)	1.0	5.5	10.8	1.3	3.3	3.1	-0.9	2.7	0.7	2.6	2.6
Trunk fat percentage	4.6	18.4	28.5	3.1	5.3	5.1	-1.6	5.2	2.5	4.9	4.8
Hand grip strength (right)	0.8	2.3	6.0	-2.5	-1.0	-1.4	-0.0	-1.7	-1.5	-1.4	-1.4
Townsend deprivation index at recruitment	0.5	0.7	2.0	-0.2	-1.3	-0.9	0.2	-0.3	-1.4	-0.5	-0.6
Current tobacco smoking	1.2	2.0	3.7	0.8	1.3	1.3	-0.6	1.7	1.1	1.9	1.9
Average weekly fortified wine intake	0.1	0.2	0.6	-0.7	0.4	-0.7	0.3	-0.1	-0.1	0.2	0.2
Maternal smoking around birth	4.0	5.8	11.7	-0.1	2.4	2.9	-0.2	3.4	1.6	3.0	2.9
Fed-up feelings	0.3	0.5	1.1	-0.6	-1.1	0.6	-0.6	-0.8	-0.5	-0.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	0.5	-0.5	0.5	-1.0	-0.2	-1.2	-0.3	-0.3
Relative age voice broke	1.0	1.5	3.1	0.7	-1.5	-0.1	1.2	-1.1	-0.6	-1.7	-1.8
Taking other prescription medications	2.7	4.1	9.0	1.8	1.7	2.1	-0.2	1.9	1.2	2.8	3.0
Age when periods started (menarche)	0.1	0.2	0.5	-0.7	0.2	0.0	-0.2	0.3	-0.4	0.6	0.5
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	5.7	2.1	1.7	2.4	0.5	2.1	1.5	2.0	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	-1.4	-0.9	-1.2	-0.5	-0.2	-1.0	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	-0.4	-0.3	-0.8	0.9	-0.7	0.1	-1.0	-1.1
Qualifications: CSEs or equivalent	0.7	0.9	6.3	-0.4	0.1	-0.5	2.5	-0.3	-0.5	-0.2	-0.2
Serious illness, injury or assault to yourself	1.4	1.6	3.5	-1.4	-1.2	-1.9	0.5	-1.7	-1.1	-1.0	-1.0
High blood pressure	2.4	6.6	11.8	2.5	3.4	3.2	-0.5	2.7	2.3	2.5	2.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	-0.2	-1.0	-0.6	0.2	-1.3	-1.3	-1.1	-1.0
Multivitamins +/- minerals	3.0	3.8	6.4	-2.0	-1.4	-2.1	-1.1	-2.2	-1.1	-2.5	-2.5
Stomach or abdominal pain in last month	1.0	1.3	2.0	-1.4	-1.4	-0.8	-0.3	-1.2	-1.0	-1.2	-1.2
Supplements: Glucosamine	0.3	0.4	1.6	0.3	0.9	0.5	0.1	0.6	1.3	0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.5	0.2	-1.0	-0.9	0.6	-1.2	0.7	-1.2	-1.1
Medication: Atenolol	4.0	5.0	13.5	3.7	2.9	2.1	1.6	1.1	2.1	1.6	1.8
Medication: Levothyroxine sodium	0.3	0.5	1.9	1.4	-0.7	0.1	0.2	0.5	0.4	0.8	0.9
Sitting height	0.9	6.7	10.4	-2.3	-2.3	-3.0	-0.1	-3.2	-2.5	-3.0	-2.9
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.1	-0.2	0.8	-1.2	1.0	-0.2	0.5	0.5
High blood pressure (mother)	3.3	4.6	8.2	-0.9	-2.5	-1.9	-0.0	-2.0	-2.3	-2.9	-2.9
Body mass index (BMI)	5.2	22.1	35.5	3.0	6.0	5.5	-1.7	5.9	2.6	5.5	5.3
Impedance of leg (left)	1.1	5.5	9.2	-1.0	-2.7	-3.0	-0.2	-2.9	-1.5	-2.8	-2.8
Leg predicted mass (left)	1.1	5.6	10.8	1.3	3.3	3.1	-0.9	2.7	0.7	2.7	2.7
Trunk fat mass	4.5	19.2	30.2	3.0	5.5	5.3	-1.7	5.3	2.3	5.1	5.0
Waist circumference	5.7	21.0	31.8	3.0	5.6	5.4	-1.8	5.6	2.2	5.5	5.4
Number of incorrect matches in round	0.2	0.4	1.1	-0.5	0.3	-0.2	-0.2	0.3	1.0	0.8	0.9
Past tobacco smoking	2.9	5.4	11.2	-1.1	-2.6	-3.4	-0.4	-2.5	-1.2	-2.8	-2.8
Alcohol usually taken with meals	2.5	4.0	6.6	-2.6	-1.8	-1.9	0.1	-2.1	-2.0	-2.3	-2.3
Nervous feelings	2.2	4.1	6.9	-0.7	-2.4	-1.5	2.0	-2.3	-0.8	-2.6	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	8.1	0.2	-1.2	-0.1	-1.9	-0.9	-2.8	-1.1	-1.1
Hearing difficulty/problems with background noise	0.5	0.8	3.0	0.1	-0.2	0.3	-1.7	-0.2	-1.2	0.8	1.0
Hair/balding pattern: Pattern 2	0.6	0.8	3.1	-1.2	-0.0	0.3	-1.8	0.1	1.1	0.5	0.5
Had menopause	0.7	0.9	3.7	1.9	0.3	-0.3	-1.8	0.2	0.4	0.2	0.1
Had other major operations	0.8	0.9	3.1	-0.5	-1.0	-1.0	-1.8	-0.6	-0.5	-0.9	-0.9
Forced vital capacity (FVC)	0.3	1.2	2.7	-0.6	-1.4	-0.7	1.0	-1.1	-1.6	-0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.6	0.0	-0.4	-0.5	0.5	-0.2	0.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.4	-0.1	0.0	-0.2	-1.2	-0.4	-0.8	-0.2	-0.1
Qualifications: None of the above	1.2	2.5	5.9	2.4	1.2	1.4	-0.7	1.5	1.9	1.5	1.4
Financial difficulties in last 2 years	1.0	1.4	5.9	-0.4	-0.5	-0.7	-2.4	0.0	-1.8	-0.6	-0.8
Mouth/teeth dental problems	2.1	3.2	7.5	-1.4	-1.6	-2.7	-1.0	-1.4	-0.7	-2.2	-2.3
Heart attack	3.5	4.5	10.6	0.9	3.3	1.9	-1.5	2.1	2.0	2.3	2.3
Allergy	0.3	0.6	2.0	0.1	1.2	-0.3	1.4	0.5	1.0	0.5	0.4
Pain all over the body in last month	1.8	2.0	4.1	0.9	1.0	1.0	0.8	1.6	1.3	2.0	2.0
Diabetes (self-reported)	6.9	10.7	16.7	2.1	3.7	3.4	-1.8	4.1	2.2	3.9	3.9
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.3	0.0	0.6	-0.5	-0.1	-0.4	-0.1	-0.1
Medication: Ramipril	1.5	1.9	3.5	0.1	1.4	1.6	-0.7	1.9	0.5	1.8	1.7
Medication: Simvastatin	9.1	13.4	21.1	3.2	4.0	3.8	0.8	4.1	2.8	4.6	4.6
Fluid intelligence score	0.1	0.3	1.2	-0.0	-0.2	0.5	0.5	-0.7	-1.1	-0.3	-0.2
Illnesses of siblings	2.3	3.2	7.9	-1.4	-1.7	-1.6	2.8	-1.5	-0.8	-1.8	-1.9
Neuroticism score	1.1	2.3	6.0	-1.1	-1.7	-0.8	0.6	-2.5	-0.8	-1.9	-1.7
Weight	2.3	11.5	21.1	2.2	4.6	4.0	-1.6	4.1	1.3	3.9	3.8
Impedance of arm (right)	1.9	8.7	14.7	-1.5	-3.3	-3.7	1.4	-3.8	-1.3	-3.5	-3.4
Arm fat percentage (right)	4.3	16.8	28.8	2.6	5.4	4.7	-1.1	5.0	2.7	4.7	4.6
Trunk fat-free mass	0.4	2.1	4.5	0.2	2.1	1.8	-0.7	1.6	0.2	1.8	1.8
Hip circumference	1.2	5.1	9.9	2.0	3.2	2.5	-1.5	2.8	0.5	2.3	2.2
Time employed in main current job	0.2	0.2	1.0	0.3	-1.0	0.1	-0.5	-0.3	-0.4	-0.3	-0.2
Alcohol intake versus 10 years previously	2.5	3.7	6.8	2.6	2.6	1.8	-1.0	1.9	1.3	1.9	1.9
Father’s age at death	1.2	1.6	3.9	-2.0	-1.3	-1.5	0.4	-0.9	-1.0	-1.2	-1.3
Worrier / anxious feelings	0.3	0.5	1.7	-0.2	0.3	1.3	1.1	0.4	1.0	0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.8	-2.2	-0.4	-0.4	-2.6	-0.9	-1.7	-0.6	-0.5
Falls in the last year	1.8	2.5	4.8	-1.9	-1.3	-1.5	-2.2	-1.2	-1.5	-1.4	-1.4
Hair/balding pattern: Pattern 3	0.7	1.0	3.1	-0.8	-0.6	-1.2	0.4	-1.7	0.5	-1.1	-1.0
Number of live births	0.6	0.8	3.6	-0.9	0.0	-0.3	-0.9	0.8	1.9	0.6	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.1	-0.9	-1.0	-0.2	0.6	-0.5	-1.8	-0.7	-0.7
Pulse rate	0.9	1.5	2.7	0.9	0.7	1.4	1.0	1.6	0.1	1.6	1.6
Happiness	2.9	3.5	6.0	-2.2	-2.4	-1.6	0.1	-2.0	-1.7	-2.0	-2.0
Noisy workplace	2.0	2.5	6.4	1.5	1.4	1.8	-1.1	2.5	0.4	1.5	1.4
Qualifications: A levels/AS levels or equivalent	3.1	6.9	9.7	-2.1	-2.4	-3.1	0.7	-3.1	-2.9	-3.0	-3.0
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.3	-1.7	-1.2	-1.8	1.8	-1.4	-1.3	-1.0	-1.0
Mouth/teeth dental problems: Dentures	2.3	3.9	9.8	1.1	1.2	3.1	-0.3	1.9	1.7	2.3	2.5
Asthma	0.1	0.3	1.1	0.3	0.5	0.2	-1.0	0.2	-0.5	0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	7.2	-0.5	-1.5	-0.8	-2.7	-1.2	-1.8	-1.3	-1.3
Medication: Cholesterol lowering	9.2	14.2	21.5	2.8	3.7	4.1	0.9	4.4	3.5	4.6	4.6
Depression (self-reported)	1.1	1.3	2.9	-0.9	-1.2	-1.4	-0.6	-1.3	-1.7	-0.7	-0.8
Medication: Lansoprazole	0.4	0.4	2.6	-1.6	-0.5	0.2	-0.4	-0.1	-0.7	-0.2	-0.1
Prospective memory result	0.4	0.4	2.0	1.0	0.3	0.6	-1.4	0.3	-0.1	-0.1	-0.2
Lung cancer (father)	0.8	0.9	5.3	-0.2	-2.3	-0.1	-0.4	0.2	-0.6	-0.7	-0.8
Illnesses of mother	0.6	0.7	1.2	-0.3	0.8	0.9	0.4	1.1	1.0	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.0	-1.3	-1.8	-0.9	0.1	-1.1	-2.0	-1.2	-1.2
Pulse wave Arterial Stiffness index	0.4	0.4	1.1	-0.3	-1.0	0.6	0.1	-0.7	-0.7	-0.7	-0.6
Impedance of arm (left)	2.1	9.8	17.2	-1.5	-3.5	-3.8	1.2	-4.2	-1.5	-3.8	-3.7
Arm fat mass (right)	4.6	18.8	30.8	2.7	5.5	5.1	-1.4	5.2	2.5	5.1	5.0
Trunk predicted mass	0.4	2.2	4.6	0.2	2.1	1.8	-0.7	1.7	0.3	1.8	1.8
Standing height	0.5	4.6	8.5	-1.6	-2.1	-2.4	0.2	-2.9	-2.1	-2.4	-2.3
Length of working week for main job	1.5	1.7	3.8	1.9	1.2	1.1	-0.1	1.1	0.5	1.6	1.7
Exposure to tobacco smoke at home	0.4	0.5	1.5	0.5	0.4	-0.7	-0.1	-0.3	-1.2	-0.8	-0.9
Breastfed as a baby	0.9	1.2	3.5	0.3	-1.0	-1.1	0.6	-1.2	-1.9	-1.0	-1.0
Tense / ‘highly strung’	0.6	1.0	1.7	-0.6	-1.0	-1.1	-0.4	-1.3	-1.1	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.0	8.7	-2.9	-1.8	-1.7	-1.2	-2.3	-2.7	-2.4	-2.3
Hair/balding pattern: Pattern 4	11.1	27.0	43.5	3.1	4.7	6.6	-3.2	6.4	2.6	6.5	6.4
Birth weight of first child	0.3	0.6	1.4	0.0	-1.2	-0.3	-1.2	-0.9	-0.2	-0.9	-0.8
Peak expiratory flow (PEF)	0.3	0.7	2.3	-1.5	-0.8	-0.1	-0.2	-0.2	-1.3	-0.5	-0.5
Pulse wave reflection index	1.0	1.2	2.7	-0.6	-1.2	-0.3	-0.4	-1.3	-1.6	-1.3	-1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.2	-1.1	-0.5	-0.3	-1.5	-0.1	-0.5	0.2	0.1
Loud music exposure frequency	0.4	0.4	1.2	-0.9	-0.8	-0.4	-1.1	-0.6	-0.1	-0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	5.8	0.1	0.2	-1.2	1.3	-0.6	-2.4	-0.9	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.7	0.8	1.2	-0.3	0.6	0.4	0.9	0.9
Blood clot in the leg (DVT)	0.5	0.6	2.4	0.4	-1.1	-0.1	-1.5	-0.2	-0.1	-0.7	-0.7
Medication: Paracetamol	0.5	0.8	4.3	-0.6	-0.5	0.5	-2.1	-0.3	-0.8	-0.5	-0.6
Headache pain in last month	1.0	1.7	2.7	-0.1	-1.0	-1.1	-1.1	-1.6	-1.5	-1.6	-1.6
Medication for cholesterol, blood pressure or diabetes	3.8	6.2	9.5	-1.7	-2.6	-2.7	0.4	-2.9	-2.3	-3.1	-3.1
Glaucoma (self-reported)	1.4	1.7	3.5	0.5	0.9	1.4	1.9	1.5	0.9	1.4	1.4
Gout (self-reported)	6.3	8.7	15.0	1.4	3.4	2.9	-1.2	2.8	3.1	3.7	3.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	0.6	-0.0	0.0	0.9	0.4	-0.7	0.6	0.6
Medication: Amlodipine	0.5	0.7	2.3	0.0	1.1	0.5	1.5	0.6	1.1	0.6	0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.2	-0.6	-1.0	-1.2	1.0	-1.5	-0.9	-1.4	-1.3
Birth weight	1.6	3.4	6.5	-1.3	-2.5	-1.8	0.3	-2.0	-1.3	-2.3	-2.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.5	0.3	-0.3	-0.3	-0.7	-0.0	-0.1	0.2	0.2
High blood pressure (siblings)	0.8	1.2	6.3	-0.5	-0.6	-0.7	-2.5	-0.9	-0.8	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.5	2.0	4.6	-1.1	-2.0	-1.2	0.2	-1.4	-2.1	-1.2	-1.1
Body fat percentage	5.0	19.6	32.1	3.4	5.7	5.1	-1.9	5.4	2.6	5.0	4.9
Leg fat percentage (right)	5.5	20.0	35.9	3.2	6.0	4.9	-2.0	5.5	2.7	5.0	4.8
Arm fat-free mass (right)	1.0	5.1	8.0	1.2	2.8	2.8	-1.9	2.6	0.3	2.6	2.6
Exposure to tobacco smoke outside home	0.4	0.6	1.1	-0.1	0.4	-1.0	-1.0	-0.6	-0.6	-0.9	-0.9
Comparative body size at age 10	0.1	0.3	0.8	-0.7	-0.9	-0.7	0.1	-0.5	0.3	-0.1	-0.1
Number of full brothers	0.1	0.2	0.6	0.4	-0.5	-0.1	0.8	0.5	0.0	-0.1	-0.2
Worry too long after embarrassment	0.7	1.1	2.4	-0.5	-1.1	-0.5	0.6	-1.5	-0.2	-1.6	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	7.2	-2.2	-1.2	-2.7	0.0	-2.1	-1.7	-1.8	-1.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.9	0.7	0.2	0.7	-1.4	-0.2	0.7	0.4	0.5
Number of children fathered	2.1	2.3	4.6	-0.0	0.9	1.8	0.4	2.1	1.0	2.1	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.3	0.1	-1.0	-1.1	1.0	-0.7	-1.1	-1.0	-1.1
Age at first live birth	0.5	0.8	5.8	0.7	0.4	-0.3	2.4	0.0	-0.1	-0.1	-0.1
Pulse wave peak to peak time	0.2	0.3	0.8	-0.0	0.8	-0.9	-0.1	0.3	0.5	0.4	0.3
Health satisfaction	0.8	1.0	5.3	-1.6	-0.4	-0.2	-2.3	-0.0	-0.6	-0.1	-0.1
Shortness of breath walking on level ground	0.9	1.0	3.4	-0.4	1.8	0.9	-0.4	0.7	-0.2	1.2	1.3
Qualifications: College or University degree	0.2	0.7	1.3	-1.0	-0.7	-1.1	0.0	-0.8	-1.2	-0.6	-0.6
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.3	-0.2	-0.9	0.4	-0.6	-0.6	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.6	-1.2	-1.1	-1.1	1.9	-1.4	-1.9	-0.7	-0.6
Emphysema/chronic bronchitis	3.1	3.5	7.3	-2.1	-2.7	-1.0	-1.5	-2.0	-1.7	-1.8	-1.7
Medication for pain relief, constipation, heartburn	1.4	2.3	7.4	0.1	-0.8	-2.0	2.7	-1.7	-0.2	-1.4	-1.2
Neck or shoulder pain in last month	3.1	4.4	16.7	-0.6	-1.5	-2.1	-4.1	-1.4	-1.6	-1.9	-1.9
Medication: Blood pressure	1.7	3.0	6.3	1.7	2.5	1.6	-0.7	1.7	1.8	1.7	1.7
Angina (self-reported)	4.9	6.5	10.5	1.4	3.2	2.9	0.1	2.7	2.6	2.9	2.9
Migraine (self-reported)	3.3	4.0	6.5	-2.0	-1.8	-1.9	-0.8	-2.6	-1.9	-2.4	-2.3
Medication: Ibuprofen	0.6	0.7	4.8	0.0	-0.4	0.3	-2.2	-0.2	-0.9	-0.2	-0.2
Medication: Allopurinol	3.3	4.3	8.5	1.1	2.1	2.3	-1.5	1.9	1.4	2.7	2.9
Medication: Omeprazole	0.4	0.5	1.8	0.4	0.0	0.6	-1.3	0.8	-0.2	0.7	0.6
Medication: Seretide 50 evohaler	1.3	1.5	3.0	1.4	1.0	0.8	0.7	1.3	0.1	1.7	1.7
Mean time to correctly identify matches	3.2	6.2	11.2	2.1	2.1	2.5	-0.5	2.9	1.9	3.3	3.4
Heart disease (mother)	0.2	0.3	0.7	0.4	0.4	0.2	-0.5	0.4	0.7	0.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	-0.5	1.3	0.1	-0.0	0.7	1.0	1.0	1.2
Whole body fat mass	4.7	19.7	32.3	3.1	5.7	5.3	-1.8	5.4	2.3	5.1	5.0
Leg fat mass (right)	5.2	20.2	35.1	3.2	5.9	5.2	-2.1	5.4	2.4	5.0	4.9
Arm predicted mass (right)	1.1	5.4	8.7	1.3	3.0	2.9	-1.6	2.6	0.4	2.7	2.7
Pulse rate, automated reading	1.6	5.0	7.3	2.1	2.5	2.3	-0.8	2.7	2.2	2.5	2.4
Alcohol intake frequency.	0.7	1.6	4.0	-0.6	-1.3	-1.5	-0.5	-1.6	-2.0	-0.9	-0.8
Comparative height size at age 10	0.9	5.2	11.0	-1.6	-2.5	-2.5	-0.8	-3.3	-0.6	-2.8	-2.6
Number of full sisters	0.7	0.8	2.6	-0.4	0.9	0.4	-1.6	0.7	-0.0	1.1	1.1
Suffer from ‘nerves’	2.7	4.2	6.9	-1.6	-1.5	-1.2	2.5	-2.3	-1.6	-2.6	-2.6
Overall health rating	0.3	0.7	2.7	0.2	0.6	0.8	-1.6	0.6	-0.5	0.8	0.8
Chest pain or discomfort	0.4	0.5	1.7	-0.4	1.0	0.4	-1.3	-0.3	-1.0	0.3	0.3
Had major operations	0.3	0.4	1.1	-0.7	-1.1	-0.3	0.7	-0.1	-0.8	-0.2	-0.2
Age at last live birth	0.9	1.3	5.2	-0.6	-0.6	-1.0	2.3	-1.1	-0.4	-1.1	-1.1
Family relationship satisfaction	1.9	2.4	4.3	-2.1	-1.9	-1.3	0.3	-1.8	-1.5	-1.5	-1.4
Leg pain on walking	1.4	1.8	4.2	-2.0	-0.9	-0.8	-1.7	-1.3	-0.6	-1.4	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.6	-1.1	-1.2	-0.7	0.6	-0.9	-1.6	-1.3	-1.3
Commuting to job workplace: Car/motor vehicle	4.1	4.7	7.6	2.1	2.4	1.8	-1.3	2.6	1.1	2.8	2.7
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	2.5	1.5	1.3	1.6	-0.5	1.6	1.6	1.5	1.4
Medication: Aspirin	4.0	5.2	8.1	0.5	2.7	2.0	-1.4	2.6	2.3	2.8	2.8
Supplements: Vitamin C	1.8	2.2	4.5	-1.1	-1.8	-1.3	-2.1	-1.5	-0.4	-1.5	-1.4
Knee pain experienced in last month	0.5	0.9	1.9	-1.4	-1.2	-0.5	-1.1	-0.6	0.3	-0.9	-0.9
Hypertension (Self-reported)	2.4	6.8	10.7	2.8	3.2	3.3	-0.4	2.6	2.3	2.6	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.6	0.3	0.3	-0.5	-0.1	-0.0	0.2	0.3
Illnesses of father: Heart disease	0.1	0.2	0.7	-0.4	0.1	-0.3	-0.9	0.5	-0.0	0.5	0.5
Illnesses of siblings: Diabetes	2.5	3.1	6.2	0.1	1.6	1.5	-1.2	2.5	1.2	2.3	2.3
Smoking status: Previous	3.1	4.7	11.1	1.1	2.6	3.3	0.5	2.2	1.0	2.5	2.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.6	-1.6	-1.5	-0.4	-0.7	-0.8	-1.6	-0.9	-0.9
Whole body fat-free mass	0.7	3.8	7.3	0.8	2.7	2.5	-0.9	2.2	0.3	2.3	2.3
Leg fat-free mass (right)	0.8	4.4	8.0	1.2	2.8	2.8	-0.9	2.3	0.6	2.4	2.4
Arm fat percentage (left)	4.3	17.1	29.5	2.6	5.4	4.8	-1.5	5.0	2.6	4.7	4.6
Average weekly red wine intake	0.2	0.3	1.6	0.5	-1.3	0.1	0.1	-0.1	-0.5	-0.0	-0.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.0	0.3	0.2	-0.8	1.7	-0.4	-0.1	-0.6	-0.7
Mood swings	1.4	2.5	4.4	-2.1	-1.9	-1.6	0.9	-2.0	-0.9	-1.4	-1.3
Loneliness, isolation	0.1	0.2	0.6	0.2	-0.6	-0.1	-0.8	-0.7	-0.0	-0.3	-0.3
Long-standing illness, disability or infirmity	0.8	1.2	3.4	-0.2	1.1	0.7	-0.3	1.2	-0.3	1.8	1.9
Ever had bowel cancer screening	0.6	0.7	3.6	-0.5	-0.9	0.4	1.9	-0.2	0.4	-0.4	-0.4
Diabetes diagnosed by doctor	6.4	10.5	17.6	1.6	3.6	3.4	-1.6	4.2	2.2	4.0	4.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	5.2	-1.3	-0.6	-1.0	-2.3	-1.0	0.5	-0.8	-0.8
Friendships satisfaction	1.1	1.3	3.3	-1.5	-0.9	-1.1	0.1	-1.1	-1.8	-1.0	-1.0
Qualifications: nursing, teaching	0.9	1.4	7.2	-1.0	0.1	-0.6	-2.7	-0.1	-1.5	-0.5	-0.5
Commuting to job workplace: Walk	0.3	0.3	2.1	0.0	-0.4	0.0	1.4	0.0	0.3	-0.3	-0.4
Eye problems/disorders: Cataract	0.7	0.8	1.8	0.8	0.6	0.6	1.3	0.1	1.2	0.9	0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	1.1	-0.5	1.0	0.2	0.2	-0.3	0.5	0.2	0.2
Medication for cholesterol	0.4	0.5	2.1	0.4	-1.2	-0.2	-1.5	-0.2	0.0	-0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	-0.6	-0.4	-1.1	-0.0	-0.9	0.2	-0.3	-0.2
Back pain experienced in last month	0.1	0.1	0.5	0.5	-0.2	0.2	0.2	-0.1	-0.7	0.3	0.3
Mineral and other dietary supplements	1.9	2.5	4.7	0.9	1.2	2.2	1.3	2.2	0.6	1.9	1.8
Breast cancer (self-reported)	0.7	0.9	1.8	-0.9	-0.9	-1.3	-1.2	-1.2	-0.0	-0.7	-0.7
Asthma (self-reported)	0.2	0.3	1.4	-0.1	0.2	0.1	-1.2	-0.0	-1.0	0.2	0.4
Osteoporosis (self-reported)	1.4	1.7	4.6	0.1	-1.0	-1.4	-0.3	-2.2	-1.5	-1.3	-1.3
Osteoarthritis (self-reported)	3.5	4.6	6.9	1.5	1.7	2.5	1.4	2.6	1.8	2.6	2.6
Medication: Aspirin	6.1	7.9	11.7	1.0	3.4	2.8	-0.9	3.2	2.9	3.4	3.4
Medication: Gliclazide	5.0	5.7	10.6	1.4	3.3	2.2	-1.1	2.8	1.3	2.9	3.0
Illnesses of father: None of the above (group 1)	0.5	0.7	1.2	-1.1	-1.1	-0.8	0.3	-1.0	-0.0	-0.8	-0.8
Smoking status: Current	1.3	2.0	3.8	1.1	1.2	1.3	-0.1	1.8	0.9	2.0	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.6	0.1	0.2	0.4	-0.3	0.8	0.1	0.2	0.0
Whole body water mass	0.6	3.5	6.9	0.7	2.6	2.4	-0.9	2.1	0.3	2.2	2.2
Leg predicted mass (right)	0.9	4.6	8.2	1.2	2.9	2.8	-0.9	2.4	0.6	2.4	2.5
Arm fat mass (left)	4.4	18.1	30.4	2.6	5.5	5.1	-1.7	5.1	2.4	4.9	4.8
Number of self-reported non-cancer illnesses	1.0	1.7	2.9	1.2	1.2	1.7	-0.6	1.3	0.6	1.6	1.6
Average weekly champagne plus white wine intake	1.5	2.1	3.7	-1.1	-1.7	-1.2	1.9	-1.2	-0.6	-1.6	-1.7
Miserableness	1.6	2.9	5.8	-2.4	-1.7	-1.5	-0.1	-1.9	-2.0	-1.5	-1.4
Guilty feelings	0.9	1.4	2.5	0.2	-1.5	-0.7	0.8	-1.5	-1.1	-1.6	-1.5
Wears glasses or contact lenses	1.4	1.6	2.9	-0.0	1.3	1.3	-0.2	1.4	1.7	1.5	1.6
Ever taken oral contraceptive pill	0.8	0.9	3.7	-1.9	0.2	-0.4	-1.0	0.4	-1.4	0.2	0.2
Hearing aid user	0.6	0.7	1.8	-0.4	1.3	0.4	0.8	1.1	-0.2	0.8	0.8
Mother’s age at death	0.1	0.1	0.4	0.6	-0.2	0.3	-0.2	-0.0	0.5	0.0	0.1
Financial situation satisfaction	0.2	0.3	0.8	-0.7	0.4	0.5	-0.9	0.1	-0.1	-0.4	-0.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.0	1.4	0.9	1.1	-0.3	1.4	0.7	0.8	0.7
Commuting to job workplace: Public transport	0.1	0.2	0.9	-0.9	-0.0	-0.1	0.6	0.2	0.1	0.2	0.2
Eye problems/disorders: Glaucoma	1.1	1.3	2.5	0.5	0.7	1.6	-0.1	1.4	0.5	1.6	1.5
Medication: Blood pressure	0.5	0.9	1.9	0.5	1.4	1.3	-0.4	1.0	0.5	1.1	1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.4	0.2	0.3	0.8	-1.6	0.6	0.6	0.9	0.9
Supplements: Fish oil (including cod liver oil)	1.8	2.4	4.0	-1.1	-1.4	-2.0	-1.2	-2.0	-0.2	-1.8	-1.8
High cholesterol (Self-reported)	2.9	5.1	8.2	2.0	2.6	2.0	1.6	2.1	1.8	2.8	2.9
Medication: Bendroflumethiazide	0.9	1.3	8.8	-0.3	1.0	-0.3	-3.0	-0.3	-0.1	0.4	0.5
Medication: Paracetamol	0.7	1.1	5.9	-0.2	0.5	1.6	-2.4	0.6	-0.3	0.3	0.2
Medication: Lisinopril	0.3	0.4	1.3	1.0	0.2	-0.4	1.2	-0.6	-0.0	0.0	0.2
Medication: Atorvastatin	1.3	1.6	2.7	0.1	1.5	1.6	0.7	1.6	0.6	1.5	1.5
Illnesses of father: High blood pressure	1.7	2.0	5.3	0.9	-0.6	-1.1	0.8	-1.9	-2.3	-1.5	-1.5
Alcohol drinker status: Never	0.5	0.6	1.3	-0.8	-1.2	-0.7	0.3	-0.7	-0.2	-1.0	-1.0
Ever smoked	1.8	3.2	7.2	0.9	2.1	2.7	0.2	1.8	0.7	2.2	2.2
Basal metabolic rate	1.0	5.5	10.5	1.1	3.2	2.9	-1.2	2.7	0.6	2.7	2.7
Leg fat percentage (left)	5.7	20.8	34.9	3.4	5.9	5.1	-2.3	5.5	2.8	5.1	5.0
Arm fat-free mass (left)	1.1	5.5	9.4	1.3	3.1	2.8	-1.5	2.7	0.6	2.7	2.7
Number of operations (self-reported)	1.7	2.5	4.8	-1.4	-2.2	-1.2	0.4	-2.0	-1.2	-1.9	-1.8
Average weekly beer plus cider intake	8.2	11.8	17.0	3.0	4.1	3.9	0.5	4.1	1.9	4.1	4.0
Irritability	0.8	1.3	3.4	-0.3	-0.9	-0.2	-1.8	-1.1	-1.7	-0.9	-0.8
Risk taking	1.1	1.6	2.7	-1.2	1.3	1.0	-1.2	0.9	1.1	1.5	1.7
Ever had prostate specific antigen (PSA) test	0.8	0.9	5.9	-0.9	0.1	0.4	2.4	0.6	0.0	0.5	0.4
Fractured/broken bones in last 5 years	0.4	0.6	3.5	0.0	-0.5	0.3	-1.9	-0.4	-0.3	-0.4	-0.4
Age started oral contraceptive pill	0.4	0.5	2.6	1.6	0.6	-0.3	-0.4	0.6	0.5	0.3	0.2
Diastolic blood pressure, automated reading	1.4	4.3	7.6	1.5	2.6	2.8	-1.7	2.5	0.8	1.9	1.9
Ever depressed for a whole week	0.2	0.3	0.9	-0.7	-0.0	-0.2	-0.8	-0.5	-0.9	-0.3	-0.3
Unable to work because of sickness or disability	0.1	0.2	1.0	-0.1	0.4	-0.1	1.0	0.3	-0.3	0.3	0.2
Commuting to job workplace: Cycle	0.4	0.5	1.7	0.0	-0.6	0.2	0.9	-0.2	-1.3	-0.7	-0.8
Myopia	0.3	0.5	2.3	-0.0	-0.6	-0.4	1.5	-0.3	0.1	-0.6	-0.6
Vascular/heart problems diagnosed by doctor	3.4	9.4	14.1	-3.0	-3.8	-3.6	0.7	-3.3	-2.9	-3.1	-3.0
Cholesterol lowering medication	2.6	3.9	7.1	0.7	2.5	1.5	0.6	2.4	1.2	2.7	2.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-0.3	-0.3	0.4	-1.0	0.5	-0.5	0.3	0.2
Pain experienced in last month	0.5	0.8	2.6	0.3	0.7	0.9	1.6	1.1	0.4	0.7	0.7
Supplements: Calcium	1.6	1.8	3.3	-1.8	-1.3	-1.1	1.2	-1.6	-1.0	-1.3	-1.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	-1.1	0.7	-0.5	-0.5	0.2	-0.6	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	3.7	4.7	10.4	0.8	3.2	1.9	-1.6	2.2	2.2	2.3	2.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.0	0.2	-1.3	-0.1	-1.7	-0.3	-0.2	-0.7	-0.7
Heart disease (siblings)	1.6	1.9	2.9	1.1	1.2	1.2	-1.6	1.2	1.3	1.7	1.7
Alcohol drinker status: Previous	1.1	1.2	2.8	0.3	-1.2	-1.7	0.8	-1.3	-1.4	-0.7	-0.6
Pack years of smoking	0.9	1.3	3.8	0.4	0.7	0.6	-1.9	1.2	0.3	1.4	1.5
Impedance of whole body	1.8	9.1	14.9	-1.2	-3.6	-3.7	0.5	-3.9	-1.8	-3.7	-3.6
Leg fat mass (left)	5.2	20.4	34.0	3.3	5.8	5.3	-2.2	5.4	2.4	5.1	5.0
Arm predicted mass (left)	1.0	5.1	9.0	1.1	3.0	2.8	-1.5	2.6	0.6	2.6	2.6