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chr16:88,934,149-90,172,696

Best TWAS P=5.04e-11 · Best GWAS P=6.03e-09 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	DEF8	0.11	0.02	enet	16	0.06	1.3e-05	-5.8	-5.7	1.2e-08	0.56	0.00	0.99	TRUE
2	GTEx	Artery Coronary	DBNDD1	0.28	0.19	lasso	2	0.13	3.2e-05	-4.9	-5.2	2.5e-07	0.46	0.11	0.81	FALSE
3	GTEx	Artery Tibial	DBNDD1	0.31	0.20	enet	20	0.27	2.0e-21	-4.9	-6.2	6.1e-10	0.46	0.15	0.85	FALSE
4	GTEx	Brain Cortex	GAS8	0.28	0.16	lasso	6	0.14	1.3e-04	-4.9	-5.6	1.9e-08	0.46	0.04	0.86	FALSE
5	GTEx	Breast Mammary Tissue (Male)	SNORD68	0.12	0.00	enet	28	0.03	8.2e-02	-4.1	-6.5	6.8e-11	0.60	0.03	0.38	TRUE
6	GTEx	Cells Transformed fibroblasts	DBNDD1	0.32	0.20	enet	36	0.20	1.2e-14	-4.9	-6.5	8.2e-11	0.45	0.15	0.85	FALSE
7	GTEx	Colon Sigmoid	DBNDD1	0.42	0.13	lasso	5	0.18	7.6e-07	-4.9	-5.5	5.0e-08	0.41	0.15	0.78	FALSE
8	GTEx	Colon Transverse	DBNDD1	0.62	0.40	enet	40	0.44	1.2e-22	-4.9	-6.0	2.1e-09	0.40	0.15	0.85	FALSE
9	GTEx	Esophagus Muscularis	DBNDD1	0.32	0.13	enet	23	0.14	1.2e-08	-4.9	-5.2	2.6e-07	0.37	0.14	0.84	FALSE
10	GTEx	Heart Atrial Appendage	DBNDD1	0.52	0.29	enet	27	0.27	9.8e-13	-4.9	-6.6	5.0e-11	0.44	0.15	0.85	TRUE
11	GTEx	Heart Left Ventricle	DBNDD1	0.24	0.18	lasso	4	0.20	7.6e-11	-4.9	-5.3	1.3e-07	0.34	0.15	0.85	FALSE
12	GTEx	Lung	DBNDD1	0.24	0.14	lasso	6	0.16	1.7e-12	-4.9	-5.3	1.2e-07	0.33	0.14	0.85	FALSE
13	GTEx	Nerve Tibial	DEF8	0.08	0.05	enet	6	0.05	3.2e-04	4.3	-6.3	3.1e-10	0.20	0.27	0.11	TRUE
14	GTEx	Pancreas	DBNDD1	0.26	0.16	enet	15	0.18	5.6e-08	-4.9	-6.4	1.3e-10	0.46	0.14	0.78	FALSE
15	GTEx	Pancreas	GAS8	0.19	0.08	lasso	4	0.06	1.9e-03	3.5	-5.7	1.5e-08	0.29	0.23	0.20	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	DBNDD1	0.40	0.19	lasso	5	0.19	8.2e-11	-4.9	-5.8	5.2e-09	0.43	0.15	0.85	TRUE
17	GTEx	Skin Not Sun Exposed Suprapubic	DEF8	0.19	0.16	lasso	13	0.16	2.5e-09	4.3	-5.3	1.4e-07	0.10	0.69	0.27	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	GAS8	0.24	0.00	enet	23	0.08	2.6e-05	1.0	-5.2	2.6e-07	0.52	0.02	0.86	FALSE
19	GTEx	Skin Sun Exposed Lower leg	DBNDD1	0.27	0.05	enet	32	0.14	6.9e-12	-4.9	-5.2	1.5e-07	0.29	0.12	0.85	FALSE
20	GTEx	Skin Sun Exposed Lower leg	DEF8	0.40	0.25	lasso	11	0.25	1.6e-20	4.3	-5.3	1.3e-07	0.14	0.67	0.31	TRUE
21	GTEx	Whole Blood	MC1R	0.08	0.00	enet	18	0.00	5.5e-01	-4.8	5.6	2.6e-08	-0.42	0.04	0.11	FALSE
22	METSIM	Adipose	MC1R	0.05	0.04	bslmm	307	0.04	1.1e-06	3.6	5.3	1.3e-07	-0.19	0.91	0.04	FALSE
23	METSIM	Adipose	RP11-368I7.4	0.04	0.03	enet	12	0.02	2.2e-04	-3.7	-5.3	9.6e-08	0.53	0.26	0.60	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FANCA	0.15	0.16	enet	13	0.16	4.2e-18	3.7	5.2	2.1e-07	-0.41	0.27	0.34	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPIRE2	0.19	0.07	enet	11	0.15	1.0e-08	4.4	5.8	6.9e-09	-0.48	0.02	0.91	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPEP1	0.06	0.01	blup	44	0.02	1.6e-03	-5.8	-6.1	1.0e-09	0.81	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPEP1	0.08	0.03	enet	3	0.04	3.2e-05	-4.4	-5.3	1.1e-07	0.45	0.04	0.92	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	FANCA	0.06	0.00	blup	77	0.03	3.7e-03	-4.7	5.2	2.0e-07	-0.58	0.02	0.84	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	SPIRE2	0.12	0.06	enet	10	0.08	8.5e-08	4.7	5.7	1.3e-08	-0.49	0.01	0.97	FALSE