TWAS hub - DPEP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0560	0.0280	0.00200	0.005	0.029	0.023	NA	0.017	0.10000	0.00170	4.3e-03	NA	1.3e-02
2	TCGA	Breast Invasive Carcinoma	0.0474	0.0188	0.00087	0.010	0.012	0.020	NA	0.016	0.00290	0.00110	5.2e-05	NA	1.9e-04
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0582	0.0290	0.00990	0.004	0.013	0.020	NA	0.016	0.12000	0.01300	2.5e-03	NA	5.2e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0368	0.0190	0.00110	0.005	0.027	0.033	NA	0.022	0.07500	0.00042	1.0e-04	NA	1.4e-03
5	TCGA	Brain Lower Grade Glioma	0.0605	0.0290	0.00030	0.013	0.021	0.019	NA	0.019	0.01100	0.00160	2.7e-03	NA	2.8e-03
6	TCGA	Prostate Adenocarcinoma	0.0787	0.0347	0.00240	0.034	0.036	0.042	NA	0.038	0.00015	0.00010	3.2e-05	NA	7.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hair Pigment	599.8	17105.9	34225.0	79.7	142.0	136.0	-34.6	149.0	185.0
Tanning	434.0	5298.0	12321.0	-31.7	-70.5	-60.8	34.4	-92.8	-111.0
Basal cell carcinoma (self-reported)	20.0	23.7	60.3	1.7	5.1	4.0	-1.9	5.8	7.8
Relative age of first facial hair	15.3	31.4	56.4	4.6	6.5	6.5	-0.6	5.0	7.5
Relative age voice broke	10.9	16.6	27.1	4.2	5.2	5.1	0.4	2.3	4.9
Medication: Blood pressure	7.6	14.5	34.7	-4.9	-0.7	-1.4	-5.9	4.9	1.3
Hypertension (Self-reported)	6.2	17.1	40.8	-4.0	0.2	-0.1	-6.3	6.4	2.5
High blood pressure	5.7	15.9	41.9	-3.4	0.8	0.5	-5.7	6.5	2.9
Worry too long after embarrassment	5.4	9.1	22.7	1.7	3.0	2.9	-0.6	3.3	4.8
High blood pressure (mother)	5.0	7.0	14.4	-3.6	-1.6	-1.5	-3.0	3.8	0.8
Schizophrenia (2014)	4.9	10.8	24.2	4.1	0.3	2.6	4.9	-3.7	-1.9
Illnesses of father: High blood pressure	4.9	6.0	14.8	-3.9	-0.6	-1.1	-3.0	2.9	1.6
Alcohol drinker status: Previous	4.9	5.6	15.3	3.9	1.3	3.1	2.5	-0.8	0.4
Peak expiratory flow (PEF)	4.8	11.0	26.5	-5.2	-3.6	-4.4	-2.1	0.7	-1.6
Forced vital capacity (FVC)	4.7	18.0	36.3	-6.0	-4.1	-5.9	-2.6	0.2	-3.7
Forced expiratory volume in 1-second (FEV1)	4.7	15.7	33.7	-5.8	-4.0	-5.6	-2.3	0.1	-2.8
Vascular/heart problems diagnosed by doctor	4.7	12.8	32.2	3.0	-0.6	-0.5	5.2	-5.7	-2.9
Medication: Lisinopril	4.6	6.0	16.6	-1.8	0.1	0.3	-3.9	4.1	1.0
Height	4.5	87.1	187.7	-10.2	-10.3	-10.8	-2.3	-1.7	-13.7
Standing height	4.5	44.2	78.1	-7.8	-7.5	-7.5	-3.8	0.0	-8.8
Osteoarthritis (self-reported)	4.5	5.8	15.1	3.9	1.1	2.0	2.1	-2.9	1.3
Other serious medical condition/disability diagnosed by doctor	4.4	5.7	11.9	3.2	2.0	2.6	3.5	-1.1	0.3
Trunk fat percentage	4.4	17.5	37.3	-0.4	-4.7	-3.6	2.1	-6.1	-5.3
Bipolar Disorder or Schizophrenia	4.2	10.3	23.3	4.2	1.5	2.5	4.8	-2.9	-2.0
Cardiovascular Disease	4.2	14.0	32.6	-4.3	-0.2	-0.4	-5.7	5.4	1.9
Frequency of tenseness / restlessness in last 2 weeks	4.1	6.4	13.5	2.5	3.7	2.7	2.4	-1.2	2.1
Medication: Aspirin	4.1	5.3	9.9	-0.7	2.0	1.1	-2.8	3.1	2.9
Medication: Atenolol	4.0	5.0	11.2	-0.9	1.9	2.0	-1.6	3.4	2.8
Hand grip strength (left)	3.9	10.3	23.4	-4.8	-2.9	-3.6	-2.9	1.6	-2.5
Had other major operations	3.9	4.7	10.0	-0.1	-2.8	-1.7	1.1	-2.5	-3.2
Chronic bronchitis/emphysema (mother)	3.9	4.5	10.5	0.4	-1.6	-0.3	2.4	-2.8	-3.2
Had menopause	3.8	4.7	14.8	1.2	3.9	2.4	1.0	0.1	2.2
Schizophrenia (2018)	3.6	7.4	14.9	3.9	2.2	2.7	3.8	-1.8	0.0
Heel T-Score	3.6	28.5	56.0	-5.6	-6.2	-7.5	-2.6	-2.3	-5.8
Trunk fat mass	3.6	15.5	30.1	-1.1	-4.7	-3.6	1.6	-5.0	-5.5
Leg pain on walking	3.6	4.5	18.1	0.9	-1.3	-1.0	1.2	-4.3	-1.9
Maternal smoking around birth	3.4	5.0	8.0	-1.3	-2.8	-2.5	-0.5	-2.6	-2.6
Medication for cholesterol	3.4	5.2	13.9	2.3	-0.2	-0.1	3.7	-3.4	-0.6
Stomach or abdominal pain in last month	3.3	4.2	10.3	2.3	-0.6	0.5	2.8	-3.2	-0.9
Forced vital capacity (FVC), Best measure	3.3	12.2	27.6	-5.3	-3.4	-4.8	-1.6	0.2	-3.0
Suffer from ‘nerves’	3.3	5.2	8.3	1.9	2.9	2.8	-0.2	2.0	2.7
Body fat percentage	3.2	12.7	30.1	0.1	-3.8	-2.7	2.1	-5.5	-4.4
Medication: Blood pressure	3.2	5.7	14.6	-1.8	0.5	1.0	-3.3	3.8	2.0
Medication: Aspirin	3.2	4.2	7.3	-0.5	2.2	1.3	-2.1	2.7	2.7
Bipolar Disorder (2018)	3.1	4.8	9.9	2.0	-0.2	0.7	3.0	-2.4	-3.1
Mean Putamen Volume	3.1	3.5	6.0	2.3	2.3	2.5	1.8	0.5	1.0
Neuroticism	3.1	7.6	15.0	2.5	3.6	3.9	-0.2	2.3	2.6
Impedance of leg (left)	3.0	14.6	25.6	-4.0	-4.2	-5.1	-2.3	-1.2	-4.6
Hair/balding pattern: Pattern 4	3.0	7.4	17.0	-0.6	1.8	1.3	-2.3	4.1	4.0
Medication: Bendroflumethiazide	3.0	4.5	9.4	-3.1	-1.0	-1.0	-2.8	2.8	-0.5
Age at First Birth	2.9	4.2	16.6	-0.8	0.6	0.4	-2.0	4.1	1.9
Hand grip strength (right)	2.9	7.9	17.7	-4.2	-2.3	-4.2	-1.7	0.1	-2.0
Emphysema/chronic bronchitis	2.9	3.3	10.5	-0.5	-1.7	-1.4	0.8	-3.2	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.0	12.8	-2.7	-2.4	-2.9	-1.2	0.3	-3.6
Breastfed as a baby	2.8	3.4	5.7	2.4	1.1	2.2	2.3	-1.6	1.1
Alzheimer’s Disease (in mother)	2.7	3.1	12.2	0.7	-0.4	-1.4	1.2	-3.5	-1.6
Body Mass Index (BMI) (2010)	2.7	3.7	6.5	2.0	1.6	2.5	1.2	1.1	2.6
Comparative body size at age 10	2.7	7.5	13.0	2.4	3.3	3.2	1.7	1.5	3.6
Impedance of leg (right)	2.6	12.4	22.7	-3.5	-4.1	-4.2	-2.2	-0.8	-4.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	21.5	-4.6	-2.6	-4.0	-1.7	0.5	-1.5
Medication: Amlodipine	2.6	3.6	7.9	-1.7	0.4	1.2	-2.8	2.7	1.4
Whole body fat mass	2.5	10.6	20.8	-0.7	-3.9	-2.8	1.5	-4.1	-4.6
Comparative height size at age 10	2.5	13.9	20.3	-4.5	-3.7	-3.3	-2.5	3.6	-4.5
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	7.5	0.1	-0.3	-1.4	2.0	-2.7	-1.4
Medication: Lansoprazole	2.4	2.8	8.3	2.9	0.2	1.1	1.0	-2.4	0.3
Depression (Nagel 2018)	2.3	3.5	6.7	0.1	2.5	2.0	-1.1	2.6	1.7
Number of live births	2.3	3.3	8.2	0.6	0.7	-0.2	2.6	-2.9	-2.0
Alcohol intake frequency.	2.3	5.3	10.9	3.3	0.9	2.1	3.0	-2.5	0.9
Diastolic blood pressure, automated reading	2.3	7.1	18.1	-3.7	-1.3	-1.4	-4.2	2.7	-0.4
Impedance of whole body	2.3	11.6	19.4	-2.9	-3.9	-4.3	-1.1	-2.6	-4.4
HbA1C	2.2	2.5	6.4	2.5	0.5	1.6	1.1	-2.1	-0.0
Average weekly fortified wine intake	2.2	2.6	7.8	0.3	1.3	1.4	-0.9	2.8	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	6.6	2.6	0.8	1.4	1.3	-2.1	0.7
Number of operations (self-reported)	2.2	3.3	7.0	-0.3	-2.2	-0.7	1.4	-2.2	-2.6
Lung FVC	2.1	10.9	24.3	-4.9	-2.8	-4.9	-2.2	0.3	-2.0
Illnesses of siblings: Diabetes	2.1	2.6	7.0	2.6	-0.6	1.3	1.3	-2.0	-0.6
Wears glasses or contact lenses	2.1	2.4	6.7	1.3	2.6	0.8	0.3	0.1	2.3
Neuroticism (Nagel 2018)	2.0	4.7	10.4	0.7	2.4	2.7	-1.5	3.2	1.5
Worry (Nagel 2018)	2.0	4.2	7.8	1.1	2.8	2.6	-0.6	2.4	1.7
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.8	0.2	-1.5	-0.8	1.3	-2.2	-2.0
Arm fat percentage (right)	2.0	7.7	22.5	1.9	-2.1	-0.2	2.8	-4.7	-2.8
Supplements: Calcium	2.0	2.2	6.1	1.3	0.1	0.5	2.3	-2.5	-0.1
Verbal and Numeric Reasoning (VNR)	1.9	4.6	9.7	-2.2	-0.6	-1.9	-2.7	3.1	1.3
Mouth/teeth dental problems: Loose teeth	1.9	2.3	6.6	1.7	0.3	1.8	2.6	-0.6	-0.6
Knee pain experienced in last month	1.9	2.9	7.3	2.4	-0.6	1.1	1.5	-2.7	-0.8
Arm fat percentage (left)	1.9	7.7	24.6	1.6	-2.2	-0.8	2.7	-5.0	-2.5
Long-standing illness, disability or infirmity	1.9	2.8	8.0	2.8	1.3	2.3	1.3	-0.3	0.3
Ever had bowel cancer screening	1.9	2.3	4.9	1.5	2.2	1.8	1.6	-0.4	0.6
Diabetes diagnosed by doctor	1.9	3.1	8.3	1.0	-2.0	-1.2	0.2	-2.9	-1.9
Back pain experienced in last month	1.9	2.7	6.9	1.9	-0.2	0.9	2.6	-2.0	-0.8
Unable to work because of sickness or disability	1.9	2.5	4.4	1.6	1.8	2.1	1.2	-0.8	1.6
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	5.2	1.9	0.4	0.7	1.7	-2.3	-1.4
Number of treatments/medications taken	1.8	3.3	6.6	1.7	1.5	2.6	-1.0	2.4	1.2
Diabetes (mother)	1.8	2.3	3.3	1.7	-0.9	1.2	1.8	-1.8	-1.6
Taking other prescription medications	1.8	2.8	8.3	2.9	-0.4	2.2	1.4	-1.1	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	7.9	-2.1	-2.8	-2.5	-0.7	-0.1	-2.3
Gout (self-reported)	1.8	2.4	6.4	-1.0	-2.5	-1.6	-0.4	-0.6	-2.1
High blood pressure (siblings)	1.8	2.6	8.3	-0.7	1.3	1.5	-0.3	2.9	1.8
Smoking status: Current	1.8	2.8	10.2	-1.2	-1.4	-0.9	1.1	-1.0	-3.2
Severe depression (siblings)	1.7	1.9	3.3	1.8	-0.7	0.3	1.8	-1.1	-1.8
Nervous feelings	1.7	3.3	9.3	1.6	2.2	3.1	0.2	1.1	1.2
Impedance of arm (left)	1.7	8.0	14.1	-1.8	-3.1	-3.1	-0.1	-3.4	-3.8
Pulse wave reflection index	1.7	2.1	6.8	0.5	1.1	1.3	-1.3	2.6	0.9
Neck or shoulder pain in last month	1.7	2.4	5.8	2.1	0.3	0.8	2.4	-1.9	-0.1
Alzheimer’s Disease (including proxy)	1.6	2.3	8.9	1.4	0.2	-0.5	1.4	-3.0	-0.9
Waist circumference	1.6	5.8	14.1	0.0	-2.6	-1.5	0.9	-3.3	-3.8
Weight	1.6	8.0	18.2	-1.6	-3.7	-2.7	0.4	-2.5	-4.3
Mouth/teeth dental problems: Dentures	1.6	2.8	8.0	2.8	0.7	2.1	0.8	-1.0	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.9	-0.4	-2.2	-0.6	-1.4	0.5	-2.1
Exposure to tobacco smoke outside home	1.6	2.1	8.2	0.4	-0.7	-1.2	0.8	-2.9	-1.4
Number of full brothers	1.6	2.1	7.2	0.1	-1.4	-0.4	-0.3	-2.7	-1.7
Mineral and other dietary supplements	1.6	2.1	4.2	-1.4	-2.1	-2.0	-1.3	0.3	-0.8
Leg fat mass (left)	1.6	6.1	12.0	-0.3	-3.0	-2.0	1.2	-3.2	-3.5
Triglycerides	1.5	2.5	6.0	1.0	-0.9	-0.1	2.4	-2.1	-1.7
Current tobacco smoking	1.5	2.4	7.6	-1.4	-1.8	-1.0	0.6	-0.4	-2.8
Past tobacco smoking	1.5	2.8	5.4	-1.7	-0.7	-1.7	-2.3	1.7	1.4
Fluid intelligence score	1.5	3.1	8.3	-1.6	-0.5	-1.1	-2.2	2.9	1.1
Hip circumference	1.5	6.5	14.6	-1.5	-3.5	-2.5	-0.3	-1.9	-3.8
Asthma	1.5	3.0	15.1	0.1	-1.5	-0.1	0.5	-0.5	-3.9
Illnesses of mother	1.5	1.9	4.5	1.6	2.0	0.5	2.1	-0.7	0.2
Arm fat mass (right)	1.5	6.1	14.8	0.8	-2.5	-1.0	2.0	-3.9	-3.1
Leg fat percentage (right)	1.5	5.3	12.9	0.6	-2.3	-1.2	1.6	-3.6	-3.1
Health satisfaction	1.5	1.9	3.1	1.8	-0.5	0.8	1.7	-1.7	-1.4
Medication: Ibuprofen	1.5	1.8	4.5	-0.1	-2.1	-0.8	-1.1	-0.2	-2.1
Medication: Omeprazole	1.5	1.8	3.1	1.5	0.4	0.6	1.5	-1.6	-1.8
Leg fat mass (right)	1.5	5.9	12.4	-0.1	-2.9	-1.8	1.2	-3.2	-3.5
Supplements: Vitamin C	1.5	1.8	6.5	1.2	1.2	0.9	2.5	-0.7	0.5
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.3	-1.7	-0.8	-0.2	-1.7	2.1	0.3
Asthma (self-reported)	1.5	3.1	15.6	0.1	-1.5	-0.2	0.5	-0.6	-4.0
Arm fat mass (left)	1.5	6.2	14.5	0.5	-2.7	-1.3	2.1	-3.8	-3.0
Commuting to job workplace: Public transport	1.5	1.7	4.1	0.6	1.4	1.6	-0.4	2.0	1.3
Leg fat percentage (left)	1.5	5.5	14.1	0.2	-2.4	-1.7	1.6	-3.8	-2.8
Pain experienced in last month	1.5	2.5	6.5	-2.1	0.2	-1.2	-2.6	1.6	0.7
Serious illness, injury or assault to yourself	1.4	1.7	3.7	1.3	1.6	1.1	1.9	-0.6	0.8
Financial difficulties in last 2 years	1.4	1.9	3.5	1.4	1.7	1.7	-0.5	-0.3	1.9
Illnesses of siblings	1.4	2.0	4.3	-1.0	-1.8	-2.1	-1.0	-0.9	-1.1
Neuroticism score	1.4	2.9	6.8	1.5	1.9	2.6	0.1	1.6	1.5
Glaucoma (self-reported)	1.4	1.6	2.1	-1.4	-1.3	-1.4	1.2	-0.8	-1.3
Mood swings	1.4	2.6	5.2	1.8	0.3	1.9	2.3	-0.2	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.1	6.2	-1.5	-2.5	-2.1	-0.0	0.5	-2.3
Diabetes (self-reported)	1.3	2.0	6.3	1.5	-1.5	-0.4	0.6	-2.5	-0.8
Overall health rating	1.3	2.8	7.0	2.7	0.7	1.9	1.3	-1.9	-0.6
Had major operations	1.3	1.5	4.2	-0.9	-2.0	-0.9	-0.5	-0.8	-1.4
Illnesses of father: None of the above (group 1)	1.3	1.6	4.6	1.4	0.3	-0.1	1.7	-2.1	-0.4
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.7	2.2	0.8	1.5	1.4	-0.1	0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.6	4.2	1.1	2.0	1.6	0.9	0.3	1.0
Respiratory disease	1.2	2.7	14.0	-0.0	-1.5	-0.1	-0.0	-0.3	-3.7
Pack years adult smoking proportion	1.2	1.8	4.2	0.0	-1.9	-0.6	0.6	-1.5	-2.1
Sitting height	1.2	8.6	22.3	-3.3	-3.1	-2.9	-0.5	0.3	-4.7
Time employed in main current job	1.2	1.4	2.8	1.3	0.8	1.3	1.7	-0.0	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.8	1.2	-0.5	0.9	1.9	-1.5	-1.7
Hair/balding pattern: Pattern 3	1.2	1.8	3.3	-1.5	-0.7	-0.9	-1.7	1.8	1.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.7	-0.7	-2.6	-0.7	0.7	-1.2	-2.0
Arm fat-free mass (right)	1.2	5.9	10.3	-3.2	-2.9	-2.8	-1.5	0.7	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.6	1.9	0.8	1.7	1.1	0.5	0.1
Qualifications: College or University degree	1.2	3.7	7.8	-2.5	-1.8	-1.4	-1.1	2.8	-1.4
Medication: Allopurinol	1.2	1.6	5.2	-0.8	-2.3	-0.7	0.5	0.3	-1.8
Heart disease (mother)	1.2	1.4	3.4	-1.5	-1.0	-0.9	-1.8	0.9	0.4
Smoking status: Previous	1.2	1.8	4.1	1.8	1.0	2.0	1.3	-0.7	-0.4
HDL Cholesterol	1.1	1.9	5.3	-0.6	0.9	0.3	-1.6	2.3	1.5
Smoking Status	1.1	2.8	7.3	0.5	-0.3	0.9	2.3	-1.6	-2.7
Vitamin and mineral supplements	1.1	1.5	3.4	-1.4	-1.1	-1.5	-1.8	0.3	-0.1
Townsend deprivation index at recruitment	1.1	1.5	3.5	1.9	0.1	1.4	0.9	-1.7	0.3
Number of incorrect matches in round	1.1	1.8	6.2	0.9	-0.1	1.2	2.5	-0.5	-1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.7	1.1	0.9	1.7	1.5	1.1	0.2
Impedance of arm (right)	1.1	5.1	15.6	-0.5	-2.2	-1.4	0.6	-2.8	-4.0
Noisy workplace	1.1	1.4	3.8	1.6	0.7	2.0	-0.1	0.2	1.1
Blood clot in the leg (DVT)	1.1	1.4	4.8	-1.4	-0.6	-2.2	0.6	-1.0	0.1
Age at first live birth	1.1	1.9	7.0	0.1	0.9	0.7	-0.4	2.7	1.7
Shortness of breath walking on level ground	1.1	1.3	3.4	0.4	-0.8	-0.5	0.6	-1.7	-1.9
Medication: Seretide 50 evohaler	1.1	1.3	5.3	-0.4	-0.5	-1.0	0.5	-1.0	-2.3
Age at last live birth	1.1	1.6	2.4	0.7	1.4	1.5	1.4	1.3	1.1
Average weekly champagne plus white wine intake	1.1	1.5	4.4	-0.6	-0.1	-0.0	-2.1	1.4	1.5
Age started oral contraceptive pill	1.1	1.4	4.2	-0.5	1.9	0.4	-0.5	0.6	2.0
Pack years of smoking	1.1	1.6	4.0	-0.1	-1.9	-0.6	0.5	-1.3	-2.0
Prostate Cancer	1.0	1.5	2.8	0.6	1.0	1.2	-1.1	1.4	1.7
Systolic Blood Pressure	1.0	4.8	9.9	-0.6	1.7	2.9	-1.1	3.1	2.5
Hearing difficulty/problems: Yes	1.0	1.5	3.9	-1.1	-0.6	-1.1	-0.5	-1.4	-2.0
Mouth/teeth dental problems	1.0	1.6	3.6	-1.9	1.2	-1.8	-0.1	1.0	0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	5.8	0.2	-1.2	-0.0	0.2	0.6	-2.4
Number of children fathered	1.0	1.1	3.9	-0.2	-0.1	-0.3	0.5	-1.5	-2.0
Eye problems/disorders: None of the above	1.0	1.2	2.7	0.8	1.6	0.8	-0.4	0.8	1.6
Angina (self-reported)	1.0	1.3	3.3	1.1	1.0	1.5	0.5	0.3	1.8
Family relationship satisfaction	1.0	1.3	1.9	-1.3	-1.4	-0.4	-1.1	1.3	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	4.2	-1.3	-0.5	-2.0	0.6	-1.0	0.1
Arm predicted mass (left)	1.0	5.1	8.3	-2.6	-2.9	-2.4	-1.1	0.4	-2.9
Intelligence (Savage-Jansen 2018)	0.9	2.6	5.0	-2.2	-1.1	-2.2	-1.7	1.4	0.2
Neuroticism (2016)	0.9	1.3	3.8	-1.0	0.4	0.7	-1.5	1.9	0.1
Blood White Count	0.9	6.9	24.3	-0.1	-1.2	-2.3	2.9	-4.9	-1.3
Angina	0.9	1.2	2.3	1.3	0.9	1.5	0.7	0.2	1.5
Diabetes (father)	0.9	1.1	2.9	0.8	-1.7	-0.3	0.7	-0.9	-1.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.7	0.3	-0.9	-0.6	0.5	-1.9	-1.2
Medication: Levothyroxine sodium	0.9	1.6	3.7	0.3	-1.9	-0.1	1.5	-1.3	-1.4
Trunk fat-free mass	0.9	5.0	9.5	-2.7	-2.4	-1.9	-1.4	1.4	-3.1
Alcohol intake versus 10 years previously	0.9	1.4	4.0	1.4	0.8	0.9	2.0	-0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.9	2.1	6.0	-1.3	-0.2	-1.0	-1.9	2.4	0.4
Depression (self-reported)	0.9	1.1	2.2	1.5	0.6	1.5	0.9	-0.0	-0.9
Arm predicted mass (right)	0.9	4.7	8.2	-2.9	-2.6	-2.6	-1.1	0.4	-2.3
Chest pain or discomfort	0.9	1.3	4.2	0.0	-1.1	-0.3	0.1	-2.1	-1.5
Breast cancer (self-reported)	0.9	1.1	3.6	0.1	-0.5	-0.7	1.9	-1.2	-0.9
Osteoporosis (self-reported)	0.9	1.1	2.5	1.2	1.6	0.7	0.8	-0.4	1.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	5.0	-0.6	0.4	0.4	0.1	2.2	0.8
Alcohol drinker status: Never	0.9	1.1	2.8	0.7	1.4	0.5	-0.6	-0.7	1.7
Basal metabolic rate	0.9	5.2	12.1	-2.2	-3.0	-2.2	-0.5	-0.2	-3.5
Commuting to job workplace: Cycle	0.9	1.0	2.5	-0.9	0.1	-0.2	-1.4	1.6	0.9
Breast Cancer	0.8	1.9	5.5	1.6	2.4	1.2	1.1	-0.6	0.6
Blood Red Count	0.8	7.8	32.5	1.5	-0.7	-3.3	0.6	-5.7	0.5
BMI	0.8	4.4	9.4	2.8	-0.8	1.3	2.6	-3.1	-0.1
Average weekly spirits intake	0.8	1.1	3.0	-0.4	1.7	0.1	-0.5	1.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.5	-1.0	-0.9	-1.2	-0.8	-1.0	-0.6
Qualifications: None of the above	0.8	1.7	3.9	1.2	1.5	1.0	2.0	-1.4	-0.2
Falls in the last year	0.8	1.1	2.5	1.6	0.3	1.3	1.1	-0.3	1.0
Trunk predicted mass	0.8	4.7	9.1	-2.6	-2.3	-1.8	-1.3	1.5	-3.0
Exposure to tobacco smoke at home	0.8	0.9	2.7	0.3	0.6	1.2	1.6	-0.9	-0.3
Tense / ‘highly strung’	0.8	1.3	3.5	0.8	1.3	1.9	0.4	1.2	0.6
Birth weight of first child	0.8	1.4	3.8	-1.3	-0.6	-1.1	-0.6	0.9	-1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.1	0.5	-0.2	-0.4	2.3	-1.2	-1.2
Migraine (self-reported)	0.8	1.0	3.8	-0.2	-1.1	-0.8	0.2	-2.0	-0.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-0.9	-1.4	-1.6	-0.4	-0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	1.2	1.2	0.9	0.8	-0.3	1.2
Miserableness	0.8	1.4	5.6	-0.0	-1.4	-0.3	0.3	-0.8	-2.4
Financial situation satisfaction	0.8	1.0	3.3	1.0	0.4	0.5	1.0	-1.8	-0.8
Arm fat-free mass (left)	0.8	4.0	7.0	-2.3	-2.6	-1.9	-1.0	0.6	-2.6
Risk taking	0.8	1.2	3.4	1.2	0.7	0.6	1.2	-1.8	-0.3
Crohns Disease (2012)	0.7	1.2	3.8	-1.0	0.0	-0.7	-1.2	0.4	-2.0
Rheumatoid Arthritis	0.7	0.9	2.8	0.9	-0.1	0.6	1.0	-1.7	-0.7
Hypothyroidism (self reported)	0.7	1.7	7.2	-0.7	-2.7	-0.3	-0.4	-0.2	-1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.8	1.2	-1.0	-0.0	0.7	-1.9	-1.1
Sensitivity / hurt feelings	0.7	1.1	2.7	-0.1	0.7	1.3	-0.8	1.6	1.1
Medication: Co-codamol	0.7	0.8	3.6	0.0	-0.2	0.9	-0.2	1.9	-0.5
Medication: Metformin	0.7	1.1	2.7	-0.6	-1.3	-1.6	-0.6	-0.6	-1.0
Supplements: Glucosamine	0.7	0.9	1.8	1.1	1.0	1.1	1.3	-0.3	0.4
Body mass index (BMI)	0.7	2.9	7.3	2.0	-0.4	0.5	2.3	-2.7	-0.5
Pulse rate	0.7	1.3	3.7	-0.5	-0.5	-1.6	0.5	-1.9	-0.7
Prospective memory result	0.7	0.8	2.4	0.3	1.3	0.5	-1.6	0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.3	0.7	-0.6	0.1	1.4	-1.5	-1.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.1	-0.4	-1.8	0.6	-1.2	0.7	-0.4
Wheeze or whistling in the chest in last year	0.7	1.3	3.5	1.5	-0.0	1.3	0.2	-0.4	-1.9
Whole body fat-free mass	0.7	3.8	8.2	-2.2	-2.3	-1.7	-0.7	0.7	-2.9
Eye problems/disorders: Glaucoma	0.7	0.9	1.9	-1.1	-0.7	-0.9	1.4	0.2	-0.8
Medication: Paracetamol	0.7	1.1	2.3	1.4	0.4	1.3	0.4	1.5	0.0
Average weekly beer plus cider intake	0.7	1.1	3.2	-1.1	-0.4	-1.1	-1.8	-0.6	-0.6
Primary Biliary Cirrhosis	0.6	0.8	2.1	-0.1	-1.4	-0.6	0.2	-1.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.0	0.6	1.4	1.1	0.4	-0.3	0.8
Fed-up feelings	0.6	1.2	2.9	1.7	0.9	1.4	0.2	-0.1	1.2
Medication: Ramipril	0.6	0.7	2.3	-0.7	-0.9	0.1	-1.5	0.9	0.3
Medication: Paracetamol	0.6	1.0	3.6	0.9	0.3	1.0	-0.2	1.9	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	1.6	-1.2	-0.6	-1.2	1.3	-1.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	-0.7	0.0	-1.0	0.9	-1.4	-0.4
Loneliness, isolation	0.6	0.8	2.3	-0.5	0.6	0.8	-0.9	0.7	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.4	-1.4	-1.2	-1.6	-0.3	-0.9	-0.7
Whole body water mass	0.6	3.7	7.9	-2.2	-2.4	-1.7	-0.7	0.6	-2.8
Ever taken oral contraceptive pill	0.6	0.7	3.0	-0.8	0.2	-0.5	-1.7	0.4	-0.1
Mother’s age at death	0.6	0.7	1.5	-0.6	0.9	0.0	-1.0	0.9	1.2
High cholesterol (Self-reported)	0.6	1.0	3.5	-0.5	-0.7	-1.1	-0.6	-1.9	-0.6
Irritability	0.6	1.1	1.9	0.7	1.4	0.8	-1.0	1.3	0.9
Heart disease (siblings)	0.6	0.8	1.8	0.8	1.4	0.7	-0.4	1.0	0.8
Fasting Glucose	0.5	0.5	1.3	0.4	-1.1	0.5	1.1	0.0	-0.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.5	0.4	-0.3	0.4	0.0	-1.2	-1.2
Systolic blood pressure, automated reading	0.5	1.6	4.5	0.7	1.3	2.1	0.7	0.5	1.3
Leg fat-free mass (left)	0.5	2.8	7.8	-1.1	-2.3	-1.2	0.5	-0.8	-2.8
Qualifications: CSEs or equivalent	0.5	0.7	2.3	0.2	-0.2	-0.6	1.1	-1.5	0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	1.0	0.1	0.4	0.6	-1.3	-0.5
Leg predicted mass (left)	0.5	2.8	7.8	-1.1	-2.3	-1.3	0.5	-0.8	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.6	-0.4	-0.7	-0.1	-0.0	-1.3	-1.0
Lung cancer (father)	0.5	0.6	2.5	-0.5	-0.6	-0.6	-0.1	-0.3	-1.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.2	-0.6	-0.6	-0.7	-1.8	0.8	-0.2
Headache pain in last month	0.5	0.8	1.6	0.7	1.1	1.1	0.1	1.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	1.1	0.3	0.9	1.0	-1.1	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.4	0.7	1.0	-0.1	0.8	1.1
Commuting to job workplace: Walk	0.5	0.5	1.6	-0.5	-0.3	-1.2	0.1	-1.3	-0.1
Eye problems/disorders: Cataract	0.5	0.6	1.3	-1.1	-0.9	-0.3	-1.0	0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	1.5	0.3	1.1	0.4	-0.2	-0.8
Number of self-reported non-cancer illnesses	0.5	0.9	1.6	0.7	-1.3	0.4	0.4	-1.1	-1.2
Guilty feelings	0.5	0.8	2.3	0.3	1.0	1.5	0.0	0.5	1.1
Fractured/broken bones in last 5 years	0.5	0.6	2.7	0.1	0.7	0.6	1.6	0.1	-0.0
Crohns Disease (2017)	0.4	1.0	3.1	0.8	0.6	1.3	-0.2	1.8	-0.5
Irritable Bowel Disease (IBD)	0.4	1.1	4.1	0.3	0.1	1.1	-0.0	2.0	-1.0
LDL Cholesterol	0.4	0.6	1.5	-0.5	-0.9	-0.7	0.2	-0.5	-1.2
Lupus	0.4	0.6	1.7	1.3	0.1	1.0	0.3	-1.0	-0.2
Ulcerative Colitis	0.4	0.6	2.3	-0.6	0.0	0.2	-0.1	0.9	-1.5
Blood Platelet Count	0.4	4.9	12.9	-2.4	-0.6	-1.1	-3.0	3.6	0.1
Supplements: Zinc	0.4	0.4	1.0	-0.7	0.2	0.7	1.0	-0.1	-0.8
Age when periods started (menarche)	0.4	0.9	3.5	0.2	0.4	-0.5	0.8	-1.9	0.9
Allergy	0.4	0.9	2.3	0.0	1.0	0.5	-0.7	1.1	1.5
Father’s age at death	0.4	0.5	1.4	0.3	-1.2	-0.3	0.8	-0.8	-0.4
Length of working week for main job	0.4	0.4	1.0	0.7	0.4	0.4	1.0	0.7	0.7
Illnesses of father: Heart disease	0.4	0.6	1.0	-0.8	0.7	-0.1	-0.8	1.0	0.8
Leg fat-free mass (right)	0.4	2.1	4.9	-1.2	-2.1	-1.2	0.3	-0.6	-2.2
Leg predicted mass (right)	0.4	2.3	5.0	-1.3	-2.2	-1.3	0.3	-0.5	-2.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.3	1.0	0.1	-0.8	0.9	0.6
Depressed Affect (Nagel 2018)	0.3	0.7	1.6	0.5	0.7	1.3	-0.6	1.0	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	1.9	0.2	-0.7	0.5	0.1	-0.2	1.4
Waist Hip Ratio (WHR)	0.3	1.4	5.1	-0.2	-0.6	-0.7	0.0	-1.6	-2.3
Lung FEV1/FVC ratio	0.3	1.6	2.6	-1.5	-1.5	-1.5	-0.3	-1.6	-0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.5	0.9	0.6	-0.5	0.9	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.7	0.1	1.3	0.9	-0.2	0.5	0.0
Multivitamins +/- minerals	0.3	0.3	1.3	-0.6	-0.5	-0.3	0.2	-0.3	-1.1
Hearing difficulty/problems with background noise	0.3	0.5	1.5	-0.4	0.3	0.3	-0.1	-1.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.4	0.4	-0.5	0.0	-0.1	-1.2	-0.4
Worrier / anxious feelings	0.3	0.5	1.2	0.4	0.7	0.9	0.4	1.1	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.6	0.9	0.8	-0.1	-0.1	0.6
Loud music exposure frequency	0.3	0.4	1.0	1.0	-0.2	0.4	0.5	-0.2	-0.9
Birth weight	0.3	0.7	1.1	0.9	0.6	1.0	0.9	-0.2	-1.0
Friendships satisfaction	0.3	0.4	0.8	0.3	-0.6	0.9	0.5	0.4	-0.7
Medication: Gliclazide	0.3	0.4	0.6	0.8	-0.8	-0.1	0.1	-0.7	-0.7
Medication: Atorvastatin	0.3	0.4	0.9	0.1	-0.7	0.3	-0.8	1.0	-0.1
Ever smoked	0.3	0.5	1.7	0.1	0.3	0.9	1.3	-0.4	-0.8
Ulcerative Colitis (UC)	0.2	0.4	1.1	-0.0	-0.3	0.3	0.1	1.0	-1.0
Chronotype (morning person)	0.2	0.5	1.2	0.0	0.9	0.4	1.1	0.9	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.1	0.2	0.8	-0.1	-0.8	0.4
Alcohol usually taken with meals	0.2	0.4	1.2	0.3	0.2	0.2	-0.0	1.0	1.1
Hair/balding pattern: Pattern 2	0.2	0.3	1.1	0.5	0.2	0.0	0.1	-1.1	0.7
Heart attack	0.2	0.2	0.4	0.5	-0.3	0.5	-0.1	0.6	-0.5
Pain all over the body in last month	0.2	0.2	0.5	0.7	0.1	0.7	0.5	-0.4	-0.2
Happiness	0.2	0.3	0.8	0.4	-0.4	0.4	0.1	-0.4	-0.9
Medication: Cholesterol lowering	0.2	0.4	1.2	0.7	0.4	0.2	-0.5	-0.2	1.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.1	-0.4	-0.3	-0.5	0.6	-0.7
Number of full sisters	0.2	0.3	0.6	-0.8	0.2	0.4	-0.7	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-0.2	-0.2	-0.5	-0.0	1.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.7	-0.5	-0.2	-0.2	0.1	-0.7
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.6	-0.5	-0.6	-0.5	0.8	0.2
Hearing aid user	0.2	0.3	0.6	0.4	0.7	0.6	-0.2	0.6	0.2
Ever depressed for a whole week	0.2	0.2	0.5	0.7	0.2	0.6	0.5	0.4	-0.1
Myopia	0.2	0.3	1.0	0.4	1.0	0.1	0.6	0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.2	-0.8	0.1	-0.5	0.5	-0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.5	-0.3	0.6	0.3	-0.2	-0.3
Reaction Time	0.1	0.2	0.8	0.2	0.9	0.2	0.1	0.1	-0.1
Ovarian Cancer	0.1	0.1	0.2	0.4	0.4	0.2	0.4	-0.2	0.2
Allergy or Eczema	0.1	0.2	0.4	0.6	-0.0	0.5	0.1	-0.6	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.0	0.0	0.5	-0.1	-0.2	-0.3
Medication: Simvastatin	0.1	0.2	0.5	-0.5	-0.3	-0.1	-0.7	-0.3	0.3
Pulse wave peak to peak time	0.1	0.1	0.4	-0.6	-0.1	-0.2	0.3	-0.5	0.0
Mean time to correctly identify matches	0.1	0.2	0.5	-0.2	0.7	0.1	0.1	0.1	-0.7
Pulse rate, automated reading	0.1	0.2	0.5	0.2	0.7	0.1	0.3	0.1	0.7
Cholesterol lowering medication	0.1	0.1	0.4	-0.4	-0.4	0.1	-0.7	0.3	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.2	0.0	0.0	0.0	0.0	-0.4	0.0
Blood Eosinophil Count	0.0	0.2	0.6	-0.2	-0.8	-0.4	-0.4	-0.5	-0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.2	-0.0	0.4	-0.2	-0.4	-0.0
Average weekly red wine intake	0.0	0.1	0.2	0.2	-0.0	-0.4	-0.3	-0.0	-0.3

Hub : Genes

DPEP1

Models

Trait associations