Best TWAS P=1.16e-10 · Best GWAS P=1.84e-11 conditioned to 0.0508
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Thyroid | THBS3 | 0.12 | 0.09 | enet | 8 | 0.09 | 3.6e-07 | 3.8 | -5.6 | 2.1e-08 | 0.59 | 0.33 | 0.67 | FALSE |
| 2 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | THBS3 | 0.04 | 0.01 | blup | 25 | 0.03 | 3.1e-04 | -4.2 | -5.5 | 3.7e-08 | 0.64 | 0.05 | 0.53 | FALSE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBA | 0.05 | 0.01 | lasso | 2 | 0.01 | 2.3e-02 | -6.7 | 6.4 | 1.2e-10 | -0.93 | 0.00 | 0.87 | TRUE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBAP1 | 0.06 | 0.06 | lasso | 9 | 0.06 | 3.5e-07 | -3.9 | 5.2 | 2.5e-07 | -0.55 | 0.64 | 0.34 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | THBS3 | 0.14 | 0.03 | enet | 16 | 0.08 | 3.8e-08 | 3.2 | -5.1 | 3.0e-07 | 0.69 | 0.00 | 0.99 | FALSE |