Best TWAS P=3.69e-23 · Best GWAS P=7.15e-33 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RPRD2 | 0.08 | -0.01 | enet | 19 | 0.00 | 4.2e-01 | -4.1 | 8.3 | 1.6e-16 | 0.30 | 0.08 | 0.27 | TRUE |
| 2 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 11.7 | 8.7 | 2.8e-18 | 0.70 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 7.2 | 9.9 | 3.7e-23 | 0.78 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 11.7 | 8.3 | 7.9e-17 | 0.72 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Brain Cerebellum | ECM1 | 0.34 | 0.21 | lasso | 6 | 0.19 | 3.2e-06 | 4.1 | 5.1 | 2.7e-07 | 0.17 | 0.39 | 0.39 | TRUE |
| 6 | GTEx | Brain Hypothalamus | RP11-316M1.12 | 0.14 | 0.03 | lasso | 6 | 0.02 | 9.9e-02 | -5.1 | 5.2 | 2.3e-07 | 0.09 | 0.08 | 0.28 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | RP11-54A4.2 | 0.07 | 0.01 | enet | 2 | 0.03 | 7.4e-02 | 6.0 | 6.1 | 1.2e-09 | 0.08 | 0.02 | 0.54 | TRUE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | ARNT | 0.11 | 0.03 | enet | 18 | 0.02 | 8.8e-02 | -3.5 | -5.5 | 3.8e-08 | -0.14 | 0.22 | 0.08 | TRUE |
| 9 | GTEx | Esophagus Muscularis | BOLA1 | 0.07 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | -5.1 | 5.8 | 5.5e-09 | 0.43 | 0.03 | 0.13 | TRUE |
| 10 | GTEx | Spleen | RP11-54A4.2 | 0.29 | 0.10 | lasso | 9 | 0.04 | 3.8e-02 | -5.2 | 5.3 | 1.1e-07 | 0.04 | 0.07 | 0.78 | FALSE |
| 11 | GTEx | Testis | CTSK | 0.07 | 0.01 | enet | 19 | 0.01 | 1.2e-01 | -3.5 | -5.4 | 5.4e-08 | -0.03 | 0.06 | 0.85 | TRUE |
| 12 | GTEx | Thyroid | MTMR11 | 0.09 | 0.05 | enet | 9 | 0.06 | 1.5e-05 | -5.1 | -5.4 | 5.9e-08 | -0.40 | 0.26 | 0.41 | FALSE |
| 13 | GTEx | Thyroid | ANP32E | 0.08 | 0.00 | enet | 15 | 0.01 | 8.6e-02 | -4.7 | 9.1 | 1.3e-19 | 0.37 | 0.04 | 0.12 | TRUE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SV2A | 0.03 | 0.02 | enet | 3 | 0.02 | 8.0e-06 | -3.3 | 5.6 | 2.8e-08 | 0.38 | 0.13 | 0.23 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SV2A | 0.05 | 0.02 | blup | 9 | 0.03 | 2.5e-04 | -5.1 | 6.6 | 5.4e-11 | 0.48 | 0.03 | 0.07 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | LASS2 | 0.03 | 0.01 | blup | 30 | 0.01 | 1.0e-02 | -4.0 | 5.4 | 7.5e-08 | 0.10 | 0.00 | 0.03 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SV2A | 0.11 | 0.10 | blup | 9 | 0.11 | 3.8e-11 | -3.3 | 5.3 | 1.1e-07 | 0.40 | 1.00 | 0.00 | TRUE |
| 18 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RPRD2 | 0.14 | 0.13 | enet | 8 | 0.13 | 1.5e-04 | 4.7 | 5.4 | 8.2e-08 | 0.04 | 0.00 | 0.44 | TRUE |