Best TWAS P=8.48e-12 · Best GWAS P=2.22e-08 conditioned to 0.087
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC26A1 | 0.12 | 0.06 | bslmm | 400 | 0.08 | 8.0e-10 | 5.0 | 6.0 | 2.1e-09 | 0.51 | 0.04 | 0.95 | FALSE |
2 | GTEx | Adipose Subcutaneous | SLC26A1 | 0.37 | 0.32 | lasso | 4 | 0.32 | 5.7e-27 | 5.0 | 5.2 | 2.3e-07 | 0.55 | 0.03 | 0.96 | FALSE |
3 | GTEx | Adipose Visceral Omentum | SLC26A1 | 0.47 | 0.36 | lasso | 7 | 0.36 | 1.8e-19 | 5.0 | 5.2 | 2.2e-07 | 0.59 | 0.03 | 0.96 | FALSE |
4 | GTEx | Artery Aorta | SLC26A1 | 0.42 | 0.37 | lasso | 6 | 0.38 | 6.4e-22 | 5.0 | 5.2 | 1.9e-07 | 0.54 | 0.03 | 0.96 | FALSE |
5 | GTEx | Artery Tibial | GAK | 0.19 | 0.03 | enet | 29 | 0.10 | 2.4e-08 | -2.8 | 5.8 | 6.5e-09 | 0.59 | 0.01 | 0.99 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | SLC26A1 | 0.33 | 0.14 | lasso | 8 | 0.15 | 1.0e-04 | 5.0 | 5.3 | 1.4e-07 | 0.55 | 0.06 | 0.78 | FALSE |
7 | GTEx | Brain Cerebellum | SLC26A1 | 0.61 | 0.41 | enet | 22 | 0.46 | 2.1e-15 | 5.0 | 6.0 | 1.9e-09 | 0.57 | 0.04 | 0.96 | TRUE |
8 | GTEx | Brain Cortex | SLC26A1 | 0.45 | 0.35 | lasso | 3 | 0.33 | 6.9e-10 | 5.0 | 5.3 | 1.0e-07 | 0.54 | 0.03 | 0.96 | FALSE |
9 | GTEx | Esophagus Muscularis | SLC26A1 | 0.38 | 0.37 | lasso | 4 | 0.36 | 4.3e-23 | 5.0 | 5.2 | 1.8e-07 | 0.57 | 0.03 | 0.96 | FALSE |
10 | GTEx | Heart Left Ventricle | SLC26A1 | 0.22 | 0.13 | enet | 10 | 0.17 | 1.4e-09 | 5.0 | 5.1 | 2.7e-07 | 0.49 | 0.04 | 0.96 | FALSE |
11 | GTEx | Lung | SLC26A1 | 0.51 | 0.41 | lasso | 9 | 0.42 | 1.2e-34 | 5.0 | 5.2 | 2.1e-07 | 0.56 | 0.03 | 0.96 | FALSE |
12 | GTEx | Muscle Skeletal | DGKQ | 0.15 | 0.07 | enet | 15 | 0.09 | 6.6e-09 | 5.0 | 5.2 | 1.8e-07 | 0.57 | 0.03 | 0.96 | FALSE |
13 | GTEx | Nerve Tibial | SLC26A1 | 0.55 | 0.49 | lasso | 4 | 0.50 | 1.0e-40 | 5.0 | 5.1 | 3.0e-07 | 0.56 | 0.03 | 0.97 | FALSE |
14 | GTEx | Pituitary | SLC26A1 | 0.37 | 0.38 | enet | 14 | 0.33 | 3.9e-09 | 5.0 | 5.5 | 4.5e-08 | 0.65 | 0.04 | 0.96 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | SLC26A1 | 0.55 | 0.38 | lasso | 8 | 0.40 | 2.7e-23 | 5.0 | 5.1 | 3.1e-07 | 0.52 | 0.03 | 0.97 | FALSE |
16 | GTEx | Spleen | SLC26A1 | 0.35 | 0.19 | lasso | 4 | 0.25 | 4.7e-07 | 5.0 | 5.4 | 6.5e-08 | 0.56 | 0.04 | 0.91 | FALSE |
17 | GTEx | Stomach | SLC26A1 | 0.26 | 0.17 | enet | 14 | 0.16 | 4.0e-08 | 5.0 | 6.2 | 6.5e-10 | 0.63 | 0.03 | 0.96 | FALSE |
18 | METSIM | Adipose | SLC26A1 | 0.16 | 0.13 | enet | 10 | 0.13 | 2.1e-18 | 5.0 | 5.2 | 2.0e-07 | 0.48 | 0.03 | 0.96 | FALSE |
19 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SLC26A1 | 0.05 | 0.01 | blup | 53 | 0.02 | 1.2e-02 | 3.9 | 5.2 | 1.7e-07 | 0.58 | 0.05 | 0.51 | FALSE |
20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCGF3 | 0.03 | 0.00 | blup | 69 | 0.01 | 3.7e-03 | 4.0 | 6.8 | 8.5e-12 | 0.34 | 0.01 | 0.30 | TRUE |
21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PCGF3 | 0.13 | 0.00 | blup | 69 | 0.04 | 1.4e-02 | -5.0 | 5.2 | 1.8e-07 | 0.10 | 0.01 | 0.63 | FALSE |