[Hub]/) : Traits : Trunk fat percentage :

chr11:118,205,702-119,659,753

Best TWAS P=5.52e-09 · Best GWAS P=4.5e-08 conditioned to 0.57

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous HMBS 0.22 0.14 lasso 3 0.16 1.1e-12 5.2 5.3 1.5e-07 0.97 0.02 0.98 FALSE
2 GTEx Adipose Visceral Omentum RP11-110I1.14 0.14 0.09 lasso 4 0.09 2.5e-05 5.4 -5.4 7.5e-08 -0.93 0.01 0.98 FALSE
3 GTEx Adrenal Gland HMBS 0.24 0.17 lasso 5 0.18 7.2e-07 5.1 5.2 2.0e-07 0.98 0.01 0.99 FALSE
4 GTEx Artery Aorta HMBS 0.24 0.14 enet 15 0.17 1.6e-09 5.1 5.2 2.3e-07 0.95 0.02 0.98 FALSE
5 GTEx Artery Coronary HMBS 0.27 0.19 lasso 4 0.17 2.3e-06 5.1 5.3 1.1e-07 0.97 0.02 0.98 FALSE
6 GTEx Brain Caudate basal ganglia VPS11 0.35 0.24 lasso 5 0.21 1.5e-06 5.1 -5.3 1.0e-07 -0.95 0.02 0.98 FALSE
7 GTEx Brain Cerebellum HMBS 0.21 0.15 lasso 3 0.15 3.3e-05 5.3 5.3 9.3e-08 0.98 0.02 0.97 FALSE
8 GTEx Brain Cortex HMBS 0.22 0.12 lasso 1 0.11 6.5e-04 5.3 5.3 1.3e-07 0.97 0.02 0.90 FALSE
9 GTEx Brain Hippocampus VPS11 0.37 0.13 lasso 4 0.11 1.4e-03 5.3 -5.3 1.0e-07 -0.98 0.02 0.88 FALSE
10 GTEx Breast Mammary Tissue HMBS 0.20 0.08 lasso 8 0.08 6.0e-05 5.3 5.2 1.6e-07 0.96 0.01 0.99 FALSE
11 GTEx Cells EBV-transformed lymphocytes HMBS 0.26 0.13 lasso 5 0.10 3.8e-04 5.1 5.3 1.2e-07 0.97 0.02 0.97 FALSE
12 GTEx Cells Transformed fibroblasts SLC37A4 0.09 0.02 enet 9 0.02 7.5e-03 5.1 5.2 2.2e-07 0.89 0.04 0.92 FALSE
13 GTEx Cells Transformed fibroblasts HMBS 0.31 0.25 lasso 7 0.25 1.0e-18 5.2 5.2 2.5e-07 0.95 0.03 0.97 FALSE
14 GTEx Colon Transverse HMBS 0.33 0.24 enet 21 0.25 1.9e-12 5.1 5.1 2.8e-07 0.97 0.01 0.98 FALSE
15 GTEx Esophagus Mucosa HMBS 0.26 0.18 lasso 5 0.18 3.9e-12 5.4 5.5 3.9e-08 0.97 0.01 0.99 FALSE
16 GTEx Lung HMBS 0.18 0.14 lasso 3 0.14 1.6e-10 5.2 5.2 1.6e-07 0.97 0.02 0.98 FALSE
17 GTEx Muscle Skeletal HMBS 0.12 0.12 lasso 3 0.12 3.7e-12 5.2 5.2 1.5e-07 0.97 0.02 0.98 FALSE
18 GTEx Muscle Skeletal RP11-110I1.14 0.24 0.12 lasso 9 0.15 2.4e-14 5.4 -5.4 6.5e-08 -0.95 0.01 0.99 FALSE
19 GTEx Pancreas HMBS 0.25 0.21 enet 10 0.20 6.9e-09 5.1 5.3 1.2e-07 0.94 0.02 0.98 FALSE
20 GTEx Pituitary VPS11 0.23 0.16 lasso 3 0.20 9.2e-06 5.5 -5.5 4.7e-08 -0.91 0.02 0.95 FALSE
21 GTEx Skin Not Sun Exposed Suprapubic HMBS 0.24 0.18 lasso 6 0.18 4.5e-10 5.1 5.2 1.7e-07 0.96 0.02 0.98 FALSE
22 GTEx Small Intestine Terminal Ileum HMBS 0.49 0.27 enet 17 0.18 9.0e-05 5.5 5.6 2.2e-08 0.98 0.01 0.98 FALSE
23 GTEx Thyroid VPS11 0.19 0.12 lasso 6 0.09 1.7e-07 5.3 -5.4 6.5e-08 -0.97 0.01 0.99 FALSE
24 GTEx Thyroid HMBS 0.22 0.20 enet 10 0.22 2.2e-16 5.1 5.3 9.6e-08 0.97 0.02 0.98 FALSE
25 GTEx Thyroid RP11-110I1.14 0.16 0.13 lasso 3 0.12 9.0e-10 5.3 -5.4 5.3e-08 -0.98 0.01 0.99 FALSE
26 GTEx Vagina HMBS 0.23 0.14 lasso 4 0.12 1.1e-03 5.2 5.7 1.5e-08 0.96 0.02 0.86 FALSE
27 METSIM Adipose HMBS 0.12 0.07 lasso 8 0.07 3.0e-10 5.4 5.3 1.0e-07 0.97 0.01 0.99 FALSE
28 ROSMAP Brain Pre-frontal Cortex VPS11 0.25 0.17 lasso 5 0.18 5.0e-23 5.5 -5.4 5.6e-08 -0.95 0.00 1.00 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma HMBS 0.08 0.03 blup 38 0.04 1.7e-04 5.5 5.6 2.2e-08 0.78 0.00 0.96 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma HMBS 0.11 0.10 enet 4 0.09 1.3e-18 5.2 5.3 9.8e-08 0.96 0.01 0.99 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma HMBS 0.28 0.14 lasso 2 0.13 8.6e-08 5.2 5.2 1.7e-07 0.97 0.00 1.00 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HMBS 0.15 0.13 blup 39 0.14 5.7e-16 5.5 5.4 5.7e-08 0.95 0.00 1.00 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma HMBS 0.13 0.04 lasso 2 0.04 9.0e-06 5.2 5.4 8.3e-08 0.92 0.00 0.98 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma VPS11 0.22 0.18 enet 7 0.21 1.2e-23 5.3 -5.4 8.3e-08 -0.92 0.01 0.99 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma HMBS 0.25 0.20 lasso 5 0.19 7.3e-22 5.1 5.2 2.5e-07 0.95 0.01 0.99 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma HMBS 0.05 0.03 lasso 8 0.02 2.1e-03 5.1 5.2 1.5e-07 0.95 0.01 0.89 FALSE
37 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma VPS11 0.24 0.15 lasso 4 0.18 1.4e-07 5.1 -5.2 2.2e-07 -0.89 0.01 0.99 FALSE
38 The Cancer Genome Atlas Prostate Adenocarcinoma HMBS 0.30 0.18 blup 38 0.18 1.0e-18 5.3 5.8 5.5e-09 0.89 0.00 0.99 TRUE
39 The Cancer Genome Atlas Rectum Adenocarcinoma HMBS 0.24 0.08 blup 38 0.04 3.6e-02 5.5 5.3 1.0e-07 0.74 0.00 0.55 FALSE
40 The Cancer Genome Atlas Stomach Adenocarcinoma HMBS 0.13 0.08 lasso 2 0.08 1.5e-06 5.1 5.2 1.9e-07 0.93 0.00 0.99 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma HMBS 0.17 0.16 lasso 2 0.16 1.1e-15 5.3 5.3 1.3e-07 0.97 0.00 0.99 FALSE