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chr11:118,205,702-119,659,753

Best TWAS P=5.52e-09 · Best GWAS P=4.5e-08 conditioned to 0.57

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HMBS	0.22	0.14	lasso	3	0.16	1.1e-12	5.2	5.3	1.5e-07	0.97	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	RP11-110I1.14	0.14	0.09	lasso	4	0.09	2.5e-05	5.4	-5.4	7.5e-08	-0.93	0.01	0.98	FALSE
3	GTEx	Adrenal Gland	HMBS	0.24	0.17	lasso	5	0.18	7.2e-07	5.1	5.2	2.0e-07	0.98	0.01	0.99	FALSE
4	GTEx	Artery Aorta	HMBS	0.24	0.14	enet	15	0.17	1.6e-09	5.1	5.2	2.3e-07	0.95	0.02	0.98	FALSE
5	GTEx	Artery Coronary	HMBS	0.27	0.19	lasso	4	0.17	2.3e-06	5.1	5.3	1.1e-07	0.97	0.02	0.98	FALSE
6	GTEx	Brain Caudate basal ganglia	VPS11	0.35	0.24	lasso	5	0.21	1.5e-06	5.1	-5.3	1.0e-07	-0.95	0.02	0.98	FALSE
7	GTEx	Brain Cerebellum	HMBS	0.21	0.15	lasso	3	0.15	3.3e-05	5.3	5.3	9.3e-08	0.98	0.02	0.97	FALSE
8	GTEx	Brain Cortex	HMBS	0.22	0.12	lasso	1	0.11	6.5e-04	5.3	5.3	1.3e-07	0.97	0.02	0.90	FALSE
9	GTEx	Brain Hippocampus	VPS11	0.37	0.13	lasso	4	0.11	1.4e-03	5.3	-5.3	1.0e-07	-0.98	0.02	0.88	FALSE
10	GTEx	Breast Mammary Tissue	HMBS	0.20	0.08	lasso	8	0.08	6.0e-05	5.3	5.2	1.6e-07	0.96	0.01	0.99	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	HMBS	0.26	0.13	lasso	5	0.10	3.8e-04	5.1	5.3	1.2e-07	0.97	0.02	0.97	FALSE
12	GTEx	Cells Transformed fibroblasts	SLC37A4	0.09	0.02	enet	9	0.02	7.5e-03	5.1	5.2	2.2e-07	0.89	0.04	0.92	FALSE
13	GTEx	Cells Transformed fibroblasts	HMBS	0.31	0.25	lasso	7	0.25	1.0e-18	5.2	5.2	2.5e-07	0.95	0.03	0.97	FALSE
14	GTEx	Colon Transverse	HMBS	0.33	0.24	enet	21	0.25	1.9e-12	5.1	5.1	2.8e-07	0.97	0.01	0.98	FALSE
15	GTEx	Esophagus Mucosa	HMBS	0.26	0.18	lasso	5	0.18	3.9e-12	5.4	5.5	3.9e-08	0.97	0.01	0.99	FALSE
16	GTEx	Lung	HMBS	0.18	0.14	lasso	3	0.14	1.6e-10	5.2	5.2	1.6e-07	0.97	0.02	0.98	FALSE
17	GTEx	Muscle Skeletal	HMBS	0.12	0.12	lasso	3	0.12	3.7e-12	5.2	5.2	1.5e-07	0.97	0.02	0.98	FALSE
18	GTEx	Muscle Skeletal	RP11-110I1.14	0.24	0.12	lasso	9	0.15	2.4e-14	5.4	-5.4	6.5e-08	-0.95	0.01	0.99	FALSE
19	GTEx	Pancreas	HMBS	0.25	0.21	enet	10	0.20	6.9e-09	5.1	5.3	1.2e-07	0.94	0.02	0.98	FALSE
20	GTEx	Pituitary	VPS11	0.23	0.16	lasso	3	0.20	9.2e-06	5.5	-5.5	4.7e-08	-0.91	0.02	0.95	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	HMBS	0.24	0.18	lasso	6	0.18	4.5e-10	5.1	5.2	1.7e-07	0.96	0.02	0.98	FALSE
22	GTEx	Small Intestine Terminal Ileum	HMBS	0.49	0.27	enet	17	0.18	9.0e-05	5.5	5.6	2.2e-08	0.98	0.01	0.98	FALSE
23	GTEx	Thyroid	VPS11	0.19	0.12	lasso	6	0.09	1.7e-07	5.3	-5.4	6.5e-08	-0.97	0.01	0.99	FALSE
24	GTEx	Thyroid	HMBS	0.22	0.20	enet	10	0.22	2.2e-16	5.1	5.3	9.6e-08	0.97	0.02	0.98	FALSE
25	GTEx	Thyroid	RP11-110I1.14	0.16	0.13	lasso	3	0.12	9.0e-10	5.3	-5.4	5.3e-08	-0.98	0.01	0.99	FALSE
26	GTEx	Vagina	HMBS	0.23	0.14	lasso	4	0.12	1.1e-03	5.2	5.7	1.5e-08	0.96	0.02	0.86	FALSE
27	METSIM	Adipose	HMBS	0.12	0.07	lasso	8	0.07	3.0e-10	5.4	5.3	1.0e-07	0.97	0.01	0.99	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	VPS11	0.25	0.17	lasso	5	0.18	5.0e-23	5.5	-5.4	5.6e-08	-0.95	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HMBS	0.08	0.03	blup	38	0.04	1.7e-04	5.5	5.6	2.2e-08	0.78	0.00	0.96	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	HMBS	0.11	0.10	enet	4	0.09	1.3e-18	5.2	5.3	9.8e-08	0.96	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	HMBS	0.28	0.14	lasso	2	0.13	8.6e-08	5.2	5.2	1.7e-07	0.97	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMBS	0.15	0.13	blup	39	0.14	5.7e-16	5.5	5.4	5.7e-08	0.95	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMBS	0.13	0.04	lasso	2	0.04	9.0e-06	5.2	5.4	8.3e-08	0.92	0.00	0.98	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS11	0.22	0.18	enet	7	0.21	1.2e-23	5.3	-5.4	8.3e-08	-0.92	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	HMBS	0.25	0.20	lasso	5	0.19	7.3e-22	5.1	5.2	2.5e-07	0.95	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMBS	0.05	0.03	lasso	8	0.02	2.1e-03	5.1	5.2	1.5e-07	0.95	0.01	0.89	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	VPS11	0.24	0.15	lasso	4	0.18	1.4e-07	5.1	-5.2	2.2e-07	-0.89	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	HMBS	0.30	0.18	blup	38	0.18	1.0e-18	5.3	5.8	5.5e-09	0.89	0.00	0.99	TRUE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	HMBS	0.24	0.08	blup	38	0.04	3.6e-02	5.5	5.3	1.0e-07	0.74	0.00	0.55	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	HMBS	0.13	0.08	lasso	2	0.08	1.5e-06	5.1	5.2	1.9e-07	0.93	0.00	0.99	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	HMBS	0.17	0.16	lasso	2	0.16	1.1e-15	5.3	5.3	1.3e-07	0.97	0.00	0.99	FALSE