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chr11:130,025,387-131,476,599

Best TWAS P=1.18e-12 · Best GWAS P=1.9e-10 conditioned to 0.033

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	SNX19	0.21	0.15	enet	24	0.16	2.3e-13	5.5	-6.1	1.1e-09	0.73	0.33	0.67	FALSE
2	GTEx	Adipose Visceral Omentum	SNX19	0.22	0.10	lasso	7	0.10	8.0e-06	5.5	-6.1	1.1e-09	0.63	0.14	0.85	FALSE
3	GTEx	Adrenal Gland	SNX19	0.24	0.16	lasso	4	0.06	3.2e-03	5.4	-6.2	7.8e-10	0.58	0.10	0.89	FALSE
4	GTEx	Artery Coronary	SNX19	0.25	0.16	lasso	11	0.18	1.4e-06	5.5	-5.1	3.0e-07	0.55	0.32	0.63	FALSE
5	GTEx	Artery Tibial	SNX19	0.22	0.14	lasso	6	0.20	1.5e-15	-2.8	-5.2	2.0e-07	0.57	0.16	0.84	FALSE
6	GTEx	Brain Caudate basal ganglia	SNX19	0.33	0.12	lasso	5	0.12	2.8e-04	5.4	-6.3	2.3e-10	0.57	0.08	0.85	FALSE
7	GTEx	Brain Cortex	SNX19	0.36	0.12	lasso	7	0.16	3.3e-05	5.1	-5.9	4.2e-09	0.53	0.05	0.92	FALSE
8	GTEx	Brain Frontal Cortex BA9	SNX19	0.41	0.20	lasso	7	0.37	7.1e-11	-5.7	-6.5	7.9e-11	0.52	0.04	0.94	FALSE
9	GTEx	Brain Hippocampus	SNX19	0.24	0.07	enet	17	0.16	1.8e-04	-5.7	-6.2	4.3e-10	0.49	0.07	0.76	FALSE
10	GTEx	Brain Hypothalamus	SNX19	0.32	0.04	lasso	5	0.13	7.4e-04	6.3	-7.1	1.2e-12	0.67	0.04	0.93	TRUE
11	GTEx	Brain Nucleus accumbens basal ganglia	RP11-890B15.3	0.46	0.16	lasso	7	0.04	3.9e-02	-4.9	-5.4	5.6e-08	0.36	0.08	0.27	FALSE
12	GTEx	Brain Putamen basal ganglia	SNX19	0.35	-0.01	enet	18	0.02	1.4e-01	-2.8	-5.9	2.8e-09	0.30	0.06	0.40	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RP11-890B15.3	0.17	0.01	lasso	4	0.02	1.0e-01	5.6	-5.3	1.1e-07	0.56	0.06	0.21	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	SNX19	0.29	0.28	lasso	2	0.26	5.1e-09	5.5	-5.5	3.2e-08	0.55	0.48	0.51	FALSE
15	GTEx	Esophagus Muscularis	SNX19	0.31	0.18	enet	23	0.25	1.2e-15	5.4	-6.3	3.8e-10	0.76	0.08	0.92	FALSE
16	GTEx	Heart Atrial Appendage	SNX19	0.50	0.20	enet	32	0.32	4.9e-15	-6.0	-6.2	4.3e-10	0.83	0.02	0.98	FALSE
17	GTEx	Heart Left Ventricle	SNX19	0.21	0.06	lasso	4	0.05	9.7e-04	5.5	-6.2	6.3e-10	0.59	0.08	0.90	FALSE
18	GTEx	Pancreas	SNX19	0.35	0.12	enet	19	0.27	1.2e-11	5.5	-5.5	3.9e-08	0.63	0.08	0.91	FALSE
19	GTEx	Pancreas	RP11-890B15.3	0.16	0.02	lasso	2	0.01	1.9e-01	-6.3	-6.3	2.3e-10	0.60	0.04	0.88	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	RP11-890B15.3	0.22	0.13	enet	16	0.21	9.0e-12	-2.8	-5.4	5.5e-08	0.49	0.96	0.04	FALSE
21	GTEx	Stomach	SNX19	0.39	0.29	lasso	13	0.27	2.0e-13	5.5	-6.2	4.4e-10	0.70	0.40	0.60	FALSE
22	GTEx	Testis	SNX19	0.59	0.25	enet	24	0.38	7.1e-18	-6.3	-6.1	1.4e-09	0.68	0.02	0.98	FALSE
23	METSIM	Adipose	RP11-890B15.3	0.12	0.12	lasso	5	0.12	9.4e-17	5.2	-5.5	3.0e-08	0.48	0.11	0.89	FALSE
24	METSIM	Adipose	SNX19	0.16	0.20	lasso	2	0.20	1.5e-28	5.2	-5.2	2.6e-07	0.54	0.83	0.17	FALSE
25	NTR	Blood	SNX19	0.06	0.05	lasso	6	0.06	9.9e-19	-3.0	-5.4	5.5e-08	0.53	0.98	0.02	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	SNX19	0.41	0.49	lasso	6	0.51	2.7e-75	5.2	-6.2	4.0e-10	0.61	0.87	0.13	FALSE
27	The Cancer Genome Atlas	Esophageal Carcinoma	SNX19	0.15	0.08	lasso	6	0.12	1.4e-04	5.2	-6.3	3.6e-10	0.66	0.04	0.91	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX19	0.11	0.19	enet	15	0.24	3.2e-26	5.2	-6.0	1.8e-09	0.61	0.84	0.16	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX19	0.17	0.20	lasso	6	0.23	9.8e-26	5.2	-5.9	3.3e-09	0.61	0.78	0.22	FALSE
30	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNX19	0.12	0.05	blup	98	0.07	3.0e-04	-3.2	-5.7	1.0e-08	0.49	0.09	0.73	FALSE
31	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SNX19	0.06	0.04	blup	100	0.06	1.3e-03	5.6	-6.4	1.3e-10	0.76	0.04	0.61	FALSE