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chr10:130,566,749-132,263,732

Best TWAS P=4.18e-09 · Best GWAS P=1.15e-07 conditioned to 0.655

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MGMT	0.29	0.27	lasso	14	0.31	6.0e-38	-5.2	5.4	6.4e-08	-0.89	0.00	1.00	FALSE
2	GTEx	Adrenal Gland	MGMT	0.39	0.25	lasso	6	0.30	1.5e-11	-5.2	5.5	3.9e-08	-0.95	0.01	0.99	FALSE
3	GTEx	Brain Cerebellar Hemisphere	MGMT	0.53	0.15	lasso	8	0.19	1.3e-05	-5.2	5.9	4.2e-09	-0.93	0.01	0.97	TRUE
4	GTEx	Breast Mammary Tissue	MGMT	0.60	0.21	enet	13	0.33	1.6e-17	-5.0	5.2	2.6e-07	-0.88	0.01	0.99	FALSE
5	GTEx	Cells Transformed fibroblasts	MGMT	0.45	0.30	enet	31	0.42	4.8e-34	-4.7	5.7	1.5e-08	-0.85	0.04	0.96	FALSE
6	GTEx	Colon Transverse	MGMT	0.47	0.24	enet	58	0.35	1.6e-17	-5.0	5.7	1.6e-08	-0.75	0.02	0.97	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	MGMT	0.34	0.31	lasso	6	0.28	9.8e-11	-4.8	5.1	2.9e-07	-0.82	0.02	0.98	FALSE
8	GTEx	Esophagus Mucosa	MGMT	0.41	0.33	enet	37	0.38	2.3e-26	-5.0	5.6	2.7e-08	-0.82	0.02	0.98	FALSE
9	GTEx	Heart Atrial Appendage	MGMT	0.41	0.17	enet	33	0.22	4.6e-10	-5.0	5.6	2.7e-08	-0.87	0.01	0.99	FALSE
10	GTEx	Liver	MGMT	0.46	0.39	lasso	4	0.42	8.2e-13	-5.0	5.2	1.7e-07	-0.84	0.02	0.98	FALSE
11	GTEx	Ovary	MGMT	0.52	0.09	enet	59	0.12	8.6e-04	-4.7	5.6	2.4e-08	-0.65	0.03	0.94	FALSE
12	GTEx	Prostate	MGMT	0.25	0.13	lasso	4	0.20	9.4e-06	-5.2	5.7	1.0e-08	-0.90	0.02	0.95	FALSE
13	GTEx	Skin Sun Exposed Lower leg	MGMT	0.45	0.30	enet	42	0.46	1.6e-41	-4.8	5.7	1.2e-08	-0.85	0.02	0.98	FALSE
14	GTEx	Stomach	MGMT	0.33	0.20	enet	9	0.25	2.3e-12	-5.1	5.5	2.9e-08	-0.93	0.01	0.99	FALSE
15	GTEx	Thyroid	MGMT	0.44	0.35	lasso	11	0.43	1.9e-35	-5.2	5.4	5.4e-08	-0.92	0.01	0.99	FALSE
16	GTEx	Vagina	MGMT	0.33	0.23	lasso	4	0.24	3.3e-06	-4.7	5.2	2.2e-07	-0.79	0.04	0.84	FALSE
17	NTR	Blood	MGMT	0.08	0.07	lasso	8	0.08	3.7e-24	-5.0	5.2	2.3e-07	-0.86	0.02	0.98	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	MGMT	0.41	0.38	enet	46	0.48	3.6e-69	-5.0	5.5	3.7e-08	-0.87	0.01	0.99	FALSE
19	YFS	Blood	MGMT	0.50	0.40	enet	94	0.55	1.6e-218	-5.0	5.3	1.3e-07	-0.81	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGMT	0.16	0.17	enet	22	0.21	2.4e-41	-5.0	5.1	3.1e-07	-0.89	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MGMT	0.18	0.03	blup	239	0.12	2.3e-06	-5.0	5.2	1.8e-07	-0.75	0.03	0.96	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MGMT	0.10	0.09	enet	23	0.10	1.9e-11	-4.7	5.4	7.6e-08	-0.74	0.06	0.93	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MGMT	0.26	0.32	lasso	10	0.37	2.9e-43	-5.3	5.4	6.7e-08	-0.94	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MGMT	0.25	0.05	blup	234	0.12	1.9e-06	-5.0	5.3	1.4e-07	-0.62	0.02	0.95	FALSE