Best TWAS P=2.83e-13 · Best GWAS P=7.84e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DPYSL5 | 0.24 | 0.23 | enet | 41 | 0.25 | 1.4e-30 | -5.4 | 5.3 | 1.4e-07 | 0.57 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | SLC35F6 | 0.10 | 0.04 | lasso | 4 | 0.05 | 4.2e-05 | -5.7 | 5.2 | 1.6e-07 | 0.76 | 0.39 | 0.20 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | DPYSL5 | 0.32 | 0.41 | lasso | 14 | 0.46 | 1.2e-66 | -5.5 | 5.2 | 2.4e-07 | 0.58 | 0.99 | 0.01 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KCNK3 | 0.24 | 0.15 | lasso | 3 | 0.15 | 6.5e-19 | 7.2 | -7.3 | 2.8e-13 | -0.99 | 0.00 | 1.00 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SLC35F6 | 0.05 | 0.04 | enet | 11 | 0.04 | 8.0e-06 | -5.7 | 5.9 | 3.3e-09 | 0.73 | 0.26 | 0.74 | FALSE |