Best TWAS P=2.9e-31 · Best GWAS P=2.42e-23 conditioned to 0.683
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADCY3 | 0.16 | 0.12 | lasso | 10 | 0.14 | 3.2e-17 | 9.56 | -11.6 | 2.9e-31 | -0.87 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CENPO | 0.07 | 0.03 | bslmm | 322 | 0.03 | 7.0e-05 | 6.25 | -6.6 | 3.5e-11 | -0.49 | 0.46 | 0.28 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | ADCY3 | 0.07 | 0.04 | lasso | 6 | 0.01 | 3.2e-02 | 8.91 | 8.4 | 4.5e-17 | 0.86 | 0.07 | 0.91 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | RP11-443B20.1 | 0.04 | 0.00 | enet | 10 | 0.00 | 1.2e-01 | 6.15 | 7.5 | 7.0e-14 | 0.81 | 0.04 | 0.90 | FALSE |
| 5 | GTEx | Artery Tibial | ADCY3 | 0.21 | 0.14 | lasso | 6 | 0.15 | 4.3e-12 | 8.68 | 9.6 | 5.6e-22 | 0.69 | 0.98 | 0.02 | FALSE |
| 6 | GTEx | Artery Tibial | RP11-443B20.1 | 0.17 | 0.08 | enet | 40 | 0.09 | 8.2e-08 | 8.68 | 8.0 | 1.0e-15 | 0.59 | 0.44 | 0.53 | FALSE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | ADCY3 | 0.25 | 0.23 | enet | 10 | 0.12 | 9.2e-05 | 8.91 | -6.5 | 7.9e-11 | -0.84 | 0.02 | 0.97 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | RP11-443B20.1 | 0.13 | 0.13 | enet | 9 | 0.05 | 9.2e-03 | 8.91 | -8.9 | 6.6e-19 | -0.93 | 0.01 | 0.96 | FALSE |
| 9 | GTEx | Nerve Tibial | ADCY3 | 0.09 | 0.05 | enet | 6 | 0.03 | 2.2e-03 | 8.68 | -10.3 | 1.1e-24 | -0.91 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Nerve Tibial | RP11-443B20.1 | 0.07 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | 8.68 | -10.3 | 1.1e-24 | -0.81 | 0.03 | 0.96 | FALSE |
| 11 | GTEx | Whole Blood | DNAJC27 | 0.08 | 0.10 | lasso | 1 | 0.10 | 2.2e-09 | 8.81 | 8.8 | 1.3e-18 | 0.80 | 0.86 | 0.14 | FALSE |
| 12 | GTEx | Whole Blood | ADCY3 | 0.23 | 0.24 | enet | 24 | 0.27 | 5.5e-25 | 9.04 | 10.1 | 8.1e-24 | 0.86 | 0.89 | 0.11 | FALSE |
| 13 | GTEx | Whole Blood | RP11-443B20.1 | 0.21 | 0.17 | enet | 32 | 0.20 | 1.8e-18 | 8.81 | 10.6 | 4.8e-26 | 0.86 | 0.74 | 0.26 | FALSE |
| 14 | METSIM | Adipose | EFR3B | 0.04 | 0.00 | bslmm | 357 | 0.00 | 9.7e-02 | 0.11 | -5.6 | 2.6e-08 | -0.37 | 0.06 | 0.08 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | 9.04 | -9.8 | 1.3e-22 | -0.89 | 0.72 | 0.28 | FALSE |
| 16 | YFS | Blood | ADCY3 | 0.07 | 0.02 | bslmm | 343 | 0.04 | 7.3e-14 | 9.87 | -5.9 | 3.6e-09 | -0.61 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POMC | 0.06 | 0.00 | enet | 12 | 0.03 | 9.3e-05 | -2.06 | -5.4 | 7.1e-08 | -0.27 | 0.01 | 0.41 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EFR3B | 0.03 | 0.05 | lasso | 1 | 0.04 | 1.9e-05 | -7.26 | -7.3 | 3.8e-13 | -0.67 | 0.46 | 0.23 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY3 | 0.03 | 0.02 | blup | 81 | 0.02 | 7.1e-04 | 5.23 | -8.4 | 5.4e-17 | -0.87 | 0.04 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | POMC | 0.14 | 0.04 | enet | 7 | 0.08 | 5.3e-10 | -2.06 | -6.3 | 3.4e-10 | -0.22 | 0.38 | 0.62 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POMC | 0.22 | 0.05 | blup | 37 | 0.03 | 2.1e-02 | -2.74 | -6.3 | 2.6e-10 | -0.12 | 0.01 | 0.29 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POMC | 0.11 | 0.08 | enet | 7 | 0.09 | 1.6e-09 | -2.06 | -5.8 | 8.0e-09 | -0.24 | 0.92 | 0.06 | FALSE |