Best TWAS P=8.89e-13 · Best GWAS P=3.52e-11 conditioned to 0.419
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | GFPT1 | 0.07 | 0.04 | enet | 11 | 0.01 | 6.9e-02 | -6.5 | 5.3 | 1.1e-07 | -0.80 | 0.03 | 0.96 | FALSE |
2 | GTEx | Adrenal Gland | NFU1 | 0.23 | 0.15 | lasso | 23 | 0.19 | 2.9e-07 | -6.4 | 5.3 | 9.9e-08 | -0.91 | 0.06 | 0.94 | FALSE |
3 | GTEx | Artery Tibial | GFPT1 | 0.09 | 0.05 | lasso | 4 | 0.02 | 1.1e-02 | -6.6 | 6.6 | 5.4e-11 | -0.99 | 0.02 | 0.98 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | AAK1 | 0.08 | 0.05 | lasso | 5 | 0.03 | 1.4e-03 | -6.4 | -6.5 | 1.1e-10 | 0.96 | 0.03 | 0.97 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | NFU1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 2.0e-03 | 5.1 | -5.1 | 2.7e-07 | 0.40 | 0.49 | 0.03 | FALSE |
6 | GTEx | Colon Transverse | AAK1 | 0.07 | 0.07 | lasso | 2 | 0.05 | 2.1e-03 | -6.0 | -5.8 | 8.3e-09 | 0.89 | 0.06 | 0.84 | FALSE |
7 | GTEx | Colon Transverse | GFPT1 | 0.20 | 0.23 | lasso | 4 | 0.22 | 4.9e-11 | -6.5 | 5.6 | 1.7e-08 | -0.92 | 0.02 | 0.98 | FALSE |
8 | GTEx | Esophagus Muscularis | GFPT1 | 0.13 | 0.01 | enet | 32 | 0.04 | 2.0e-03 | -6.5 | 5.2 | 2.1e-07 | -0.74 | 0.02 | 0.97 | FALSE |
9 | GTEx | Muscle Skeletal | GFPT1 | 0.08 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -6.5 | 5.8 | 8.8e-09 | -0.84 | 0.03 | 0.95 | FALSE |
10 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -6.5 | 7.2 | 8.9e-13 | -0.87 | 0.03 | 0.90 | TRUE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -6.5 | 6.9 | 4.0e-12 | -0.87 | 0.01 | 0.78 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GFPT1 | 0.12 | 0.05 | blup | 67 | 0.04 | 3.9e-05 | -6.5 | 6.5 | 9.3e-11 | -0.91 | 0.01 | 0.99 | FALSE |