Best TWAS P=4.97e-10 · Best GWAS P=9.67e-11 conditioned to 0.466
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CHST10 | 0.05 | 0.02 | blup | 474 | 0.04 | 1.0e-05 | 4.8 | -5.3 | 1.3e-07 | 0.59 | 0.46 | 0.52 | FALSE |
| 2 | GTEx | Artery Aorta | AFF3 | 0.14 | 0.06 | lasso | 5 | 0.07 | 1.2e-04 | -6.5 | -6.2 | 5.0e-10 | 0.84 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Muscle Skeletal | LONRF2 | 0.07 | 0.08 | lasso | 4 | 0.08 | 2.5e-08 | -5.2 | -5.2 | 2.1e-07 | 0.54 | 0.89 | 0.11 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | LONRF2 | 0.05 | 0.03 | lasso | 2 | 0.02 | 9.3e-03 | 5.3 | -5.9 | 4.4e-09 | 0.56 | 0.27 | 0.26 | TRUE |
| 5 | GTEx | Thyroid | CHST10 | 0.05 | 0.05 | lasso | 5 | 0.03 | 2.6e-03 | -5.2 | -5.8 | 5.2e-09 | 0.60 | 0.38 | 0.42 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LONRF2 | 0.06 | 0.04 | blup | 69 | 0.04 | 3.4e-05 | 5.0 | -6.1 | 1.1e-09 | 0.68 | 0.33 | 0.66 | FALSE |