Best TWAS P=2.68e-09 · Best GWAS P=4.52e-09 conditioned to 0.0115
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -5.6 | -5.4 | 6.4e-08 | 0.56 | 0.04 | 0.92 | FALSE |
2 | GTEx | Artery Aorta | C3orf38 | 0.06 | 0.06 | lasso | 7 | 0.05 | 6.0e-04 | -5.7 | 5.7 | 1.4e-08 | -0.67 | 0.05 | 0.93 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -5.7 | -5.8 | 7.4e-09 | 0.57 | 0.03 | 0.97 | FALSE |
4 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -5.6 | 6.0 | 2.7e-09 | -0.67 | 0.05 | 0.95 | TRUE |
5 | GTEx | Nerve Tibial | C3orf38 | 0.09 | 0.05 | lasso | 4 | 0.04 | 6.3e-04 | -5.6 | 5.7 | 1.5e-08 | -0.68 | 0.05 | 0.93 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF654 | 0.09 | 0.01 | lasso | 7 | 0.06 | 2.7e-04 | -5.7 | -5.3 | 1.1e-07 | 0.64 | 0.04 | 0.69 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | C3orf38 | 0.09 | 0.07 | lasso | 6 | 0.04 | 2.8e-03 | -5.6 | 5.6 | 1.8e-08 | -0.68 | 0.05 | 0.90 | FALSE |
8 | GTEx | Thyroid | C3orf38 | 0.12 | 0.08 | lasso | 18 | 0.07 | 1.0e-05 | -5.6 | 5.6 | 2.0e-08 | -0.68 | 0.05 | 0.95 | FALSE |
9 | GTEx | Uterus | ZNF654 | 0.29 | -0.01 | lasso | 4 | 0.01 | 1.7e-01 | -5.7 | -5.2 | 1.5e-07 | 0.66 | 0.04 | 0.63 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C3orf38 | 0.01 | 0.01 | lasso | 3 | 0.01 | 1.2e-03 | -5.6 | 5.5 | 3.4e-08 | -0.65 | 0.02 | 0.68 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C3orf38 | 0.02 | 0.01 | blup | 24 | 0.02 | 2.0e-03 | -5.6 | 5.5 | 5.0e-08 | -0.65 | 0.02 | 0.77 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf38 | 0.02 | 0.03 | lasso | 1 | 0.03 | 1.9e-04 | -5.7 | 5.7 | 1.4e-08 | -0.69 | 0.02 | 0.80 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf38 | 0.03 | 0.05 | lasso | 1 | 0.05 | 8.1e-06 | -5.7 | 5.7 | 1.4e-08 | -0.69 | 0.02 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF654 | 0.03 | 0.04 | lasso | 3 | 0.03 | 4.6e-04 | -5.7 | -5.7 | 1.2e-08 | 0.69 | 0.02 | 0.94 | FALSE |