Best TWAS P=9.1e-10 · Best GWAS P=2.84e-10 conditioned to 0.0303
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | SUPT3H | 0.27 | 0.10 | lasso | 7 | 0.06 | 3.4e-04 | 5.7 | -6.1 | 9.1e-10 | -0.84 | 0.06 | 0.94 | TRUE |
2 | GTEx | Cells Transformed fibroblasts | SUPT3H | 0.15 | 0.10 | lasso | 4 | 0.13 | 8.8e-10 | 5.9 | -5.2 | 1.9e-07 | -0.83 | 0.07 | 0.93 | FALSE |
3 | GTEx | Esophagus Mucosa | SUPT3H | 0.08 | 0.09 | lasso | 3 | 0.08 | 6.4e-06 | 5.7 | -5.9 | 3.4e-09 | -0.83 | 0.06 | 0.93 | FALSE |
4 | GTEx | Nerve Tibial | SUPT3H | 0.17 | 0.12 | lasso | 5 | 0.10 | 2.2e-07 | 5.6 | -5.6 | 1.8e-08 | -0.84 | 0.09 | 0.91 | FALSE |
5 | GTEx | Pancreas | SUPT3H | 0.11 | 0.07 | lasso | 2 | 0.05 | 3.6e-03 | 6.1 | -6.1 | 1.1e-09 | -0.86 | 0.06 | 0.83 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | SUPT3H | 0.07 | 0.03 | lasso | 5 | 0.04 | 4.2e-04 | 5.6 | -5.7 | 1.2e-08 | -0.81 | 0.08 | 0.84 | FALSE |
7 | GTEx | Spleen | SUPT3H | 0.32 | 0.06 | enet | 12 | 0.11 | 9.5e-04 | 6.3 | -5.8 | 5.7e-09 | -0.89 | 0.03 | 0.91 | FALSE |
8 | YFS | Blood | SUPT3H | 0.06 | 0.09 | lasso | 13 | 0.12 | 2.2e-36 | 5.6 | -5.2 | 1.8e-07 | -0.84 | 0.18 | 0.82 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT3H | 0.02 | 0.01 | blup | 191 | 0.01 | 3.0e-03 | 5.7 | -5.7 | 1.0e-08 | -0.79 | 0.07 | 0.92 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUPT3H | 0.04 | 0.01 | blup | 191 | 0.02 | 6.5e-03 | -3.6 | -5.5 | 2.8e-08 | -0.81 | 0.05 | 0.93 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT3H | 0.07 | 0.05 | enet | 12 | 0.08 | 1.1e-09 | -3.5 | -5.4 | 5.6e-08 | -0.84 | 0.12 | 0.88 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUPT3H | 0.03 | 0.03 | lasso | 2 | 0.02 | 8.9e-04 | 6.0 | -6.1 | 9.4e-10 | -0.86 | 0.07 | 0.80 | FALSE |
13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SUPT3H | 0.12 | 0.08 | blup | 191 | 0.09 | 2.8e-04 | 5.8 | -6.0 | 1.5e-09 | -0.92 | 0.05 | 0.93 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | SUPT3H | 0.06 | 0.04 | lasso | 4 | 0.05 | 2.1e-05 | 5.7 | -6.1 | 1.2e-09 | -0.83 | 0.06 | 0.91 | FALSE |