Best TWAS P=9.57e-08 · Best GWAS P=2.62e-08 conditioned to 0.000958
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | TRIM4 | 0.40 | 0.39 | lasso | 5 | 0.40 | 4.5e-22 | 5.0 | -5.3 | 1.3e-07 | 0.49 | 0.04 | 0.95 | FALSE |
2 | GTEx | Skin Not Sun Exposed Suprapubic | TRIM4 | 0.18 | 0.09 | enet | 17 | 0.13 | 1.8e-07 | 5.0 | -5.2 | 1.8e-07 | 0.45 | 0.05 | 0.95 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | TRIM4 | 0.39 | 0.26 | lasso | 11 | 0.25 | 5.5e-21 | 5.0 | -5.1 | 3.1e-07 | 0.45 | 0.04 | 0.96 | FALSE |
4 | GTEx | Stomach | TRIM4 | 0.34 | 0.27 | enet | 35 | 0.28 | 6.1e-14 | 5.0 | -5.1 | 2.7e-07 | 0.46 | 0.05 | 0.95 | FALSE |
5 | GTEx | Whole Blood | TRIM4 | 0.12 | 0.05 | lasso | 5 | 0.06 | 5.9e-06 | 4.9 | -5.2 | 2.0e-07 | 0.47 | 0.06 | 0.93 | FALSE |
6 | METSIM | Adipose | TRIM4 | 0.17 | 0.22 | lasso | 13 | 0.22 | 3.9e-32 | 4.9 | -5.1 | 2.9e-07 | 0.47 | 0.04 | 0.95 | FALSE |
7 | The Cancer Genome Atlas | Glioblastoma Multiforme | TRIM4 | 0.23 | 0.13 | blup | 52 | 0.20 | 1.4e-06 | 5.0 | -5.3 | 9.6e-08 | 0.51 | 0.04 | 0.95 | TRUE |
8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TRIM4 | 0.12 | 0.14 | blup | 52 | 0.16 | 7.2e-08 | -4.8 | -5.2 | 2.4e-07 | 0.46 | 0.08 | 0.91 | FALSE |