Best TWAS P=4.96e-13 · Best GWAS P=8.27e-75 conditioned to 1.4e-69
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | LEMD3 | 0.14 | 0.05 | lasso | 8 | 0.05 | 1.1e-03 | -4.5 | -6.1 | 1.4e-09 | 0.11 | 0.46 | 0.03 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | RBMS1P1 | 0.17 | 0.03 | lasso | 11 | 0.04 | 7.3e-03 | 10.2 | -7.2 | 5.0e-13 | -0.40 | 0.06 | 0.41 | TRUE |
| 3 | GTEx | Nerve Tibial | LEMD3 | 0.12 | 0.14 | enet | 13 | 0.16 | 2.0e-11 | -4.7 | -5.9 | 3.3e-09 | 0.11 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEMD3 | 0.02 | 0.02 | blup | 36 | 0.02 | 5.9e-03 | -6.0 | -5.4 | 5.9e-08 | 0.12 | 0.01 | 0.83 | FALSE |