Best TWAS P=3.44e-10 · Best GWAS P=2.02e-09 conditioned to 0.37
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NTR | Blood | PARK7 | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-05 | 5.6 | 5.6 | 1.7e-08 | 0.88 | 0.02 | 0.98 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | RP11-431K24.1 | 0.16 | 0.16 | bslmm | 384 | 0.17 | 3.1e-21 | -5.6 | -6.2 | 6.0e-10 | -0.41 | 0.09 | 0.91 | FALSE |
| 3 | YFS | Blood | PARK7 | 0.08 | 0.11 | lasso | 6 | 0.11 | 4.4e-34 | 5.6 | 5.7 | 1.5e-08 | 0.86 | 0.14 | 0.86 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERRFI1 | 0.01 | 0.01 | blup | 27 | 0.00 | 4.3e-02 | 5.6 | -5.8 | 5.7e-09 | -0.89 | 0.01 | 0.80 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PARK7 | 0.03 | 0.03 | enet | 3 | 0.02 | 1.3e-03 | 6.0 | 6.3 | 3.4e-10 | 0.89 | 0.00 | 0.94 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | PARK7 | 0.03 | 0.03 | lasso | 1 | 0.02 | 5.0e-03 | 5.6 | 5.6 | 2.8e-08 | 0.86 | 0.01 | 0.74 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | VAMP3 | 0.11 | 0.07 | lasso | 4 | 0.05 | 7.5e-04 | 5.5 | -5.5 | 5.1e-08 | -0.51 | 0.00 | 0.98 | FALSE |