Best TWAS P=1.12e-12 · Best GWAS P=1.48e-11 conditioned to 0.557
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | MARK3 | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.5e-03 | 6.7 | 7.1 | 1.1e-12 | 0.91 | 0.04 | 0.82 | TRUE |
| 2 | GTEx | Thyroid | TRMT61A | 0.11 | 0.03 | lasso | 4 | 0.02 | 1.2e-02 | 6.7 | -6.4 | 1.9e-10 | -0.95 | 0.01 | 0.98 | FALSE |
| 3 | YFS | Blood | MARK3 | 0.04 | 0.04 | lasso | 3 | 0.04 | 1.6e-12 | 6.4 | 6.3 | 2.5e-10 | 0.87 | 0.07 | 0.93 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | MARK3 | 0.10 | 0.03 | blup | 61 | 0.03 | 4.0e-04 | -4.5 | -5.3 | 1.2e-07 | -0.53 | 0.03 | 0.14 | FALSE |