Best TWAS P=5.73e-14 · Best GWAS P=1.67e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | VPS13C | 0.08 | 0.04 | lasso | 2 | 0.02 | 1.3e-02 | -6.0 | 6.0 | 1.6e-09 | -0.69 | 0.22 | 0.55 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | VPS13C | 0.16 | 0.06 | enet | 15 | 0.05 | 9.2e-04 | 6.6 | 6.3 | 2.8e-10 | -0.64 | 0.42 | 0.34 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | VPS13C | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-07 | 6.5 | 6.6 | 5.1e-11 | -0.82 | 0.38 | 0.62 | FALSE |
| 4 | GTEx | Spleen | VPS13C | 0.27 | 0.19 | lasso | 7 | 0.12 | 6.6e-04 | 6.2 | 6.6 | 4.3e-11 | -0.80 | 0.28 | 0.50 | FALSE |
| 5 | GTEx | Whole Blood | VPS13C | 0.09 | 0.00 | enet | 35 | 0.00 | 1.9e-01 | -6.7 | 5.2 | 1.6e-07 | -0.59 | 0.09 | 0.73 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2CD4A | 0.03 | 0.01 | blup | 59 | 0.02 | 7.2e-03 | -6.7 | -5.2 | 1.9e-07 | 0.82 | 0.02 | 0.74 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2CD4A | 0.09 | 0.11 | lasso | 1 | 0.08 | 9.4e-04 | -7.5 | -7.5 | 5.7e-14 | 0.99 | 0.02 | 0.85 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS13C | 0.07 | 0.03 | enet | 15 | 0.03 | 5.3e-04 | -7.5 | 6.1 | 1.0e-09 | -0.73 | 0.02 | 0.92 | FALSE |