Best TWAS P=1.99e-08 · Best GWAS P=2.36e-08 conditioned to 0.00305
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | SLC5A11 | 0.23 | 0.28 | lasso | 10 | 0.28 | 1.6e-42 | -5.3 | -5.3 | 1.1e-07 | 0.54 | 0.03 | 0.97 | FALSE |
2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SLC5A11 | 0.17 | 0.21 | lasso | 4 | 0.21 | 1.7e-17 | -5.2 | -5.5 | 4.7e-08 | 0.53 | 0.00 | 1.00 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC5A11 | 0.12 | 0.17 | enet | 9 | 0.18 | 1.1e-35 | -5.3 | -5.6 | 2.0e-08 | 0.56 | 0.00 | 1.00 | TRUE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SLC5A11 | 0.27 | 0.24 | lasso | 6 | 0.24 | 4.5e-12 | -5.4 | -5.5 | 5.0e-08 | 0.60 | 0.00 | 1.00 | FALSE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC5A11 | 0.27 | 0.21 | lasso | 2 | 0.20 | 5.2e-12 | -5.4 | -5.4 | 7.1e-08 | 0.54 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC5A11 | 0.13 | 0.15 | enet | 8 | 0.15 | 6.6e-17 | -5.2 | -5.1 | 2.8e-07 | 0.52 | 0.00 | 1.00 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC5A11 | 0.07 | 0.07 | enet | 7 | 0.06 | 1.7e-07 | -5.2 | -5.4 | 7.1e-08 | 0.55 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC5A11 | 0.14 | 0.20 | enet | 9 | 0.20 | 2.2e-23 | -5.3 | -5.1 | 2.7e-07 | 0.53 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC5A11 | 0.06 | 0.05 | lasso | 1 | 0.05 | 4.9e-06 | -5.3 | -5.3 | 1.1e-07 | 0.54 | 0.00 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SLC5A11 | 0.30 | 0.33 | lasso | 2 | 0.32 | 2.8e-14 | -5.2 | -5.4 | 5.8e-08 | 0.62 | 0.00 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC5A11 | 0.54 | 0.32 | lasso | 6 | 0.30 | 1.8e-12 | -5.2 | -5.3 | 1.1e-07 | 0.59 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC5A11 | 0.26 | 0.28 | lasso | 6 | 0.31 | 1.0e-32 | -5.3 | -5.4 | 7.7e-08 | 0.50 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SLC5A11 | 0.17 | 0.21 | lasso | 3 | 0.18 | 4.9e-11 | -5.2 | -5.2 | 2.7e-07 | 0.52 | 0.00 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SLC5A11 | 0.20 | 0.05 | lasso | 4 | 0.04 | 2.8e-02 | -5.3 | -5.3 | 1.1e-07 | 0.51 | 0.00 | 0.83 | FALSE |
15 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SLC5A11 | 0.21 | 0.10 | lasso | 5 | 0.07 | 2.2e-03 | -5.3 | -5.2 | 1.8e-07 | 0.53 | 0.00 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC5A11 | 0.35 | 0.44 | lasso | 4 | 0.44 | 4.2e-47 | -5.3 | -5.4 | 5.2e-08 | 0.55 | 0.00 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SLC5A11 | 0.24 | 0.15 | lasso | 3 | 0.14 | 1.1e-04 | -5.3 | -5.3 | 1.1e-07 | 0.54 | 0.00 | 0.97 | FALSE |