Best TWAS P=9.52e-12 · Best GWAS P=1.16e-11 conditioned to 2.34e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GPRC5B | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | -6.1 | 6.8 | 9.5e-12 | 0.31 | 0.20 | 0.50 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | AC002550.5 | 0.59 | 0.48 | enet | 23 | 0.58 | 1.2e-16 | -3.9 | -5.2 | 2.0e-07 | -0.19 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | AC002550.5 | 0.37 | 0.29 | lasso | 3 | 0.35 | 4.8e-09 | -5.3 | -5.1 | 3.1e-07 | -0.22 | 0.72 | 0.20 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | THUMPD1 | 0.13 | 0.16 | enet | 16 | 0.16 | 4.2e-12 | -5.3 | -5.5 | 3.5e-08 | 0.04 | 0.02 | 0.98 | TRUE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | KNOP1 | 0.51 | 0.44 | enet | 22 | 0.56 | 5.3e-24 | -4.7 | -5.3 | 1.1e-07 | -0.27 | 0.92 | 0.08 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | AC002550.5 | 0.62 | 0.54 | enet | 35 | 0.63 | 4.4e-29 | -3.8 | -5.4 | 6.5e-08 | -0.27 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Testis | AC004381.6 | 0.18 | 0.10 | lasso | 7 | 0.08 | 1.8e-04 | -5.4 | -5.5 | 4.9e-08 | 0.04 | 0.02 | 0.95 | FALSE |
| 8 | METSIM | Adipose | ACSM1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 9.5e-09 | -5.3 | -5.2 | 1.8e-07 | 0.05 | 0.03 | 0.97 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | THUMPD1 | 0.08 | 0.12 | enet | 24 | 0.12 | 3.0e-15 | -5.3 | 5.3 | 1.4e-07 | -0.03 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCK | 0.03 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.4 | -5.7 | 1.6e-08 | -0.25 | 0.04 | 0.91 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | THUMPD1 | 0.04 | 0.04 | blup | 30 | 0.03 | 2.3e-03 | -5.3 | -5.5 | 4.5e-08 | 0.03 | 0.01 | 0.85 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ACSM3 | 0.06 | 0.06 | lasso | 13 | 0.05 | 2.8e-06 | -5.3 | 5.3 | 1.0e-07 | -0.04 | 0.01 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Thyroid Carcinoma | ACSM3 | 0.06 | 0.04 | blup | 43 | 0.03 | 5.9e-04 | -5.4 | 5.5 | 3.6e-08 | -0.05 | 0.01 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | GPRC5B | 0.06 | 0.01 | blup | 38 | 0.01 | 2.4e-02 | -3.9 | -6.1 | 9.5e-10 | -0.43 | 0.01 | 0.10 | FALSE |