Best TWAS P=6.54e-10 · Best GWAS P=1.75e-10 conditioned to 0.592
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -4.6 | -6.0 | 2.0e-09 | 0.56 | 0.08 | 0.85 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C3orf38 | 0.09 | 0.00 | lasso | 5 | 0.00 | 5.2e-01 | -2.5 | 5.1 | 3.0e-07 | -0.51 | 0.05 | 0.24 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -6.2 | -6.2 | 6.5e-10 | 0.57 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -4.8 | 5.5 | 3.6e-08 | -0.67 | 0.15 | 0.84 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | CGGBP1 | 0.25 | 0.15 | enet | 30 | 0.16 | 1.5e-07 | -3.5 | -5.3 | 1.3e-07 | 0.60 | 0.17 | 0.69 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CGGBP1 | 0.30 | 0.07 | enet | 11 | 0.09 | 2.3e-09 | -6.4 | -5.6 | 1.7e-08 | 0.80 | 0.00 | 1.00 | FALSE |