TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Trunk fat-free mass
:
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chr3:84,317,575-86,808,226
Best TWAS P=5.37e-19 · Best GWAS P=1.86e-19 conditioned to 0.00346
84.5M
85M
85.5M
86M
86.5M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
CADM2
0.05
0.03
lasso
3
0.04
5.0e-05
8.8
8.9
5.4e-19
0.83
0.04
0.95
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
CADM2
0.08
0.04
lasso
4
0.05
2.1e-06
8.8
8.8
1.9e-18
0.79
0.06
0.94
FALSE
1
METSIM
Adipose
CADM2
0.05
0.06
lasso
10
0.06
1.3e-09
6.8
7.4
1.1e-13
0.63
0.91
0.09
FALSE
5
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
CADM2
0.14
0.05
blup
339
0.09
2.7e-04
8.4
6.0
1.7e-09
0.78
0.08
0.67
FALSE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
CADM2
0.06
0.00
blup
339
0.00
2.7e-01
-4.6
-5.4
5.1e-08
-0.40
0.06
0.14
FALSE