Best TWAS P=2.36e-12 · Best GWAS P=5.23e-10 conditioned to 0.285
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM160A1 | 0.04 | 0.04 | blup | 436 | 0.06 | 1.8e-07 | -4.1 | 5.8 | 6.1e-09 | -0.63 | 0.76 | 0.24 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | SH3D19 | 0.28 | 0.22 | lasso | 5 | 0.20 | 9.3e-06 | 6.2 | -6.1 | 1.1e-09 | 0.80 | 0.03 | 0.96 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-164P12.4 | 0.47 | 0.44 | enet | 18 | 0.35 | 6.6e-10 | 6.1 | 6.1 | 9.0e-10 | -0.81 | 0.03 | 0.97 | FALSE |
4 | GTEx | Brain Cerebellum | RP11-164P12.4 | 0.48 | 0.40 | lasso | 17 | 0.49 | 2.2e-16 | -4.7 | 5.4 | 8.0e-08 | -0.66 | 0.04 | 0.96 | FALSE |
5 | GTEx | Colon Sigmoid | PET112 | 0.13 | 0.08 | enet | 18 | 0.03 | 2.6e-02 | -4.2 | 5.7 | 1.5e-08 | -0.69 | 0.20 | 0.56 | FALSE |
6 | GTEx | Heart Atrial Appendage | RP11-164P12.3 | 0.13 | 0.03 | lasso | 5 | 0.02 | 4.4e-02 | -5.0 | 5.2 | 1.7e-07 | -0.76 | 0.13 | 0.53 | FALSE |
7 | GTEx | Spleen | RP11-164P12.4 | 0.36 | 0.26 | lasso | 10 | 0.20 | 5.8e-06 | 6.2 | 6.2 | 7.6e-10 | -0.82 | 0.03 | 0.96 | FALSE |
8 | NTR | Blood | FAM160A1 | 0.03 | 0.02 | enet | 26 | 0.02 | 1.4e-07 | -6.2 | 7.0 | 2.4e-12 | -0.94 | 0.02 | 0.98 | TRUE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM160A1 | 0.04 | 0.02 | blup | 99 | 0.02 | 1.2e-05 | 6.2 | 6.1 | 8.3e-10 | -0.91 | 0.03 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160A1 | 0.06 | 0.05 | lasso | 3 | 0.04 | 1.8e-03 | -6.2 | 6.2 | 7.1e-10 | -0.97 | 0.03 | 0.79 | FALSE |
11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAM160A1 | 0.07 | 0.03 | lasso | 3 | 0.05 | 1.9e-04 | -6.2 | 5.3 | 8.6e-08 | -0.88 | 0.04 | 0.93 | FALSE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FAM160A1 | 0.08 | 0.05 | blup | 99 | 0.05 | 2.9e-03 | -5.0 | 6.0 | 1.7e-09 | -0.90 | 0.04 | 0.71 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM160A1 | 0.09 | 0.10 | lasso | 2 | 0.10 | 3.3e-10 | 5.9 | 6.0 | 2.5e-09 | -0.76 | 0.04 | 0.96 | FALSE |
14 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FAM160A1 | 0.16 | 0.14 | enet | 33 | 0.11 | 6.6e-04 | 6.1 | 6.1 | 1.1e-09 | -0.83 | 0.03 | 0.96 | FALSE |