Best TWAS P=2.57e-13 · Best GWAS P=3.36e-10 conditioned to 0.0143
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | INPP5E | 0.18 | 0.14 | enet | 21 | 0.21 | 1.6e-24 | 6.0 | -5.7 | 9.7e-09 | -0.89 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adrenal Gland | INPP5E | 0.18 | 0.02 | enet | 23 | 0.10 | 2.2e-04 | 4.7 | -5.3 | 1.0e-07 | -0.56 | 0.13 | 0.43 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | INPP5E | 0.23 | 0.20 | enet | 8 | 0.22 | 7.2e-07 | 5.6 | -5.5 | 3.5e-08 | -0.62 | 0.18 | 0.71 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | SNHG7 | 0.37 | 0.10 | lasso | 6 | 0.27 | 2.5e-08 | -3.9 | 7.3 | 2.6e-13 | 0.39 | 0.09 | 0.48 | TRUE |
5 | GTEx | Brain Cerebellar Hemisphere | INPP5E | 0.25 | 0.23 | enet | 6 | 0.17 | 3.4e-05 | 5.4 | -5.8 | 8.1e-09 | -0.68 | 0.18 | 0.75 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | GPSM1 | 0.26 | 0.07 | lasso | 4 | 0.11 | 9.6e-04 | 2.2 | -5.1 | 2.8e-07 | -0.70 | 0.02 | 0.88 | FALSE |
7 | GTEx | Brain Cerebellum | INPP5E | 0.40 | 0.30 | enet | 20 | 0.29 | 3.6e-09 | 5.6 | -5.5 | 2.9e-08 | -0.63 | 0.24 | 0.76 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | CARD9 | 0.10 | 0.01 | enet | 15 | 0.02 | 8.0e-03 | -1.0 | -5.3 | 1.5e-07 | -0.47 | 0.16 | 0.55 | FALSE |
9 | GTEx | Esophagus Mucosa | INPP5E | 0.11 | 0.12 | lasso | 3 | 0.12 | 1.0e-08 | 5.4 | -5.4 | 5.5e-08 | -0.67 | 0.27 | 0.73 | FALSE |
10 | GTEx | Esophagus Muscularis | SDCCAG3 | 0.10 | 0.02 | enet | 5 | 0.02 | 3.6e-02 | 3.4 | -5.5 | 3.8e-08 | -0.59 | 0.04 | 0.86 | FALSE |
11 | GTEx | Heart Atrial Appendage | INPP5E | 0.13 | 0.12 | lasso | 2 | 0.10 | 3.5e-05 | 5.6 | -5.6 | 2.6e-08 | -0.71 | 0.11 | 0.67 | FALSE |
12 | GTEx | Lung | CARD9 | 0.08 | 0.04 | enet | 6 | 0.04 | 2.5e-04 | 5.3 | 5.4 | 7.7e-08 | 0.59 | 0.46 | 0.48 | FALSE |
13 | GTEx | Nerve Tibial | INPP5E | 0.13 | 0.17 | enet | 10 | 0.14 | 3.7e-10 | 5.4 | -5.7 | 1.2e-08 | -0.64 | 0.34 | 0.66 | FALSE |
14 | GTEx | Ovary | INPP5E | 0.24 | 0.13 | enet | 11 | 0.15 | 1.9e-04 | 5.2 | -6.5 | 8.1e-11 | -0.59 | 0.08 | 0.52 | FALSE |
15 | GTEx | Ovary | SEC16A | 0.33 | 0.06 | enet | 10 | 0.14 | 3.4e-04 | 4.7 | -6.5 | 8.9e-11 | -0.45 | 0.06 | 0.10 | TRUE |
16 | GTEx | Skin Sun Exposed Lower leg | INPP5E | 0.10 | 0.10 | lasso | 2 | 0.09 | 5.2e-08 | 5.4 | -5.2 | 1.8e-07 | -0.66 | 0.24 | 0.76 | FALSE |
17 | GTEx | Stomach | SEC16A | 0.15 | 0.09 | lasso | 4 | 0.10 | 1.8e-05 | 5.7 | -5.6 | 2.4e-08 | -0.69 | 0.10 | 0.88 | FALSE |
18 | GTEx | Testis | SDCCAG3 | 0.15 | 0.09 | lasso | 4 | 0.13 | 3.3e-06 | 4.3 | -5.4 | 6.6e-08 | -0.84 | 0.07 | 0.91 | FALSE |
19 | GTEx | Thyroid | INPP5E | 0.23 | 0.35 | enet | 16 | 0.37 | 8.2e-30 | 4.7 | -5.4 | 8.3e-08 | -0.74 | 0.81 | 0.19 | FALSE |
20 | GTEx | Uterus | INPP5E | 0.60 | 0.04 | enet | 10 | 0.22 | 3.4e-05 | 5.9 | -5.7 | 1.6e-08 | -0.53 | 0.07 | 0.39 | FALSE |
21 | GTEx | Whole Blood | SEC16A | 0.07 | 0.05 | lasso | 5 | 0.04 | 1.3e-04 | 5.6 | -6.2 | 7.9e-10 | -0.72 | 0.06 | 0.94 | FALSE |
22 | GTEx | Whole Blood | SDCCAG3 | 0.07 | 0.03 | enet | 6 | 0.02 | 3.4e-03 | 4.9 | -5.4 | 8.2e-08 | -0.79 | 0.13 | 0.81 | FALSE |
23 | GTEx | Whole Blood | CARD9 | 0.08 | 0.07 | lasso | 1 | 0.05 | 4.2e-05 | 5.4 | 5.4 | 7.4e-08 | 0.55 | 0.36 | 0.63 | FALSE |
24 | YFS | Blood | CARD9 | 0.22 | 0.37 | lasso | 5 | 0.39 | 1.3e-137 | 5.4 | 5.3 | 1.2e-07 | 0.64 | 0.39 | 0.61 | FALSE |
25 | YFS | Blood | INPP5E | 0.33 | 0.55 | lasso | 6 | 0.57 | 2.9e-235 | 5.9 | -5.9 | 4.3e-09 | -0.70 | 0.05 | 0.95 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC16A | 0.02 | 0.00 | blup | 69 | 0.01 | 1.0e-03 | 5.6 | -5.2 | 1.8e-07 | -0.75 | 0.02 | 0.89 | FALSE |
27 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | INPP5E | 0.25 | 0.10 | lasso | 3 | 0.09 | 4.9e-05 | 5.9 | -6.2 | 7.8e-10 | -0.73 | 0.03 | 0.93 | FALSE |
28 | The Cancer Genome Atlas | Colon Adenocarcinoma | INPP5E | 0.11 | 0.08 | lasso | 2 | 0.08 | 3.4e-05 | 5.9 | -5.9 | 2.9e-09 | -0.72 | 0.02 | 0.88 | FALSE |
29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INPP5E | 0.07 | 0.04 | blup | 54 | 0.07 | 6.0e-05 | 6.3 | -6.3 | 2.1e-10 | -0.84 | 0.01 | 0.97 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SDCCAG3 | 0.05 | 0.01 | blup | 61 | 0.01 | 5.9e-02 | 6.0 | -5.6 | 2.7e-08 | -0.81 | 0.01 | 0.88 | FALSE |
31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEC16A | 0.08 | 0.10 | lasso | 4 | 0.08 | 1.9e-08 | 6.2 | -6.0 | 1.5e-09 | -0.98 | 0.00 | 1.00 | FALSE |
32 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | INPP5E | 0.10 | 0.06 | blup | 54 | 0.08 | 8.1e-04 | 5.4 | -5.9 | 3.8e-09 | -0.82 | 0.05 | 0.61 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | INPP5E | 0.11 | 0.16 | lasso | 3 | 0.16 | 2.4e-15 | 5.2 | -5.5 | 5.1e-08 | -0.70 | 0.63 | 0.37 | FALSE |