Best TWAS P=1.81e-11 · Best GWAS P=5.99e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-529H20.5 | 0.14 | 0.16 | lasso | 3 | 0.15 | 3.0e-12 | -4.7 | -5.3 | 1.3e-07 | 0.02 | 0.17 | 0.83 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-529H20.6 | 0.20 | 0.14 | lasso | 4 | 0.18 | 6.4e-10 | -4.8 | -5.5 | 4.7e-08 | 0.03 | 0.16 | 0.83 | FALSE |
| 3 | GTEx | Artery Tibial | ATXN3 | 0.13 | 0.11 | lasso | 3 | 0.10 | 5.8e-08 | -5.3 | -5.3 | 1.3e-07 | 0.01 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-529H20.5 | 0.07 | 0.00 | lasso | 4 | 0.00 | 4.7e-01 | -5.6 | -5.6 | 2.7e-08 | 0.02 | 0.02 | 0.88 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Female) | ATXN3 | 0.18 | 0.04 | lasso | 4 | 0.03 | 3.3e-02 | -5.3 | -5.3 | 1.1e-07 | 0.02 | 0.07 | 0.85 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | -5.6 | 5.8 | 5.9e-09 | 0.00 | 0.03 | 0.96 | TRUE |
| 7 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | 6.9 | -6.7 | 1.8e-11 | -1.00 | 0.00 | 0.99 | TRUE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | TRIP11 | 0.16 | 0.13 | lasso | 11 | 0.12 | 3.7e-05 | -5.3 | -5.4 | 7.5e-08 | -0.01 | 0.06 | 0.91 | FALSE |
| 9 | GTEx | Esophagus Mucosa | RP11-529H20.6 | 0.13 | 0.11 | lasso | 10 | 0.13 | 7.9e-09 | -4.8 | -5.2 | 2.3e-07 | 0.02 | 0.07 | 0.92 | FALSE |
| 10 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | 5.9 | -6.2 | 5.9e-10 | -0.47 | 0.05 | 0.80 | FALSE |
| 11 | GTEx | Lung | RP11-529H20.6 | 0.08 | 0.05 | enet | 15 | 0.05 | 1.8e-04 | -4.8 | -5.5 | 5.0e-08 | 0.02 | 0.11 | 0.87 | FALSE |
| 12 | GTEx | Prostate | RP11-529H20.6 | 0.28 | 0.00 | lasso | 5 | 0.05 | 2.5e-02 | -4.8 | -5.4 | 8.5e-08 | 0.05 | 0.09 | 0.40 | FALSE |
| 13 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | -4.8 | 5.7 | 1.1e-08 | 0.03 | 0.08 | 0.43 | FALSE |
| 14 | GTEx | Stomach | ATXN3 | 0.24 | 0.09 | lasso | 3 | 0.11 | 5.0e-06 | -4.8 | -5.1 | 3.0e-07 | 0.02 | 0.12 | 0.88 | FALSE |
| 15 | GTEx | Testis | RP11-529H20.5 | 0.19 | 0.05 | lasso | 10 | 0.05 | 4.2e-03 | -4.7 | -5.4 | 7.1e-08 | 0.02 | 0.06 | 0.92 | FALSE |
| 16 | GTEx | Whole Blood | RP11-529H20.6 | 0.15 | 0.13 | lasso | 4 | 0.16 | 3.8e-14 | -4.8 | -5.2 | 2.4e-07 | 0.03 | 0.14 | 0.85 | FALSE |
| 17 | METSIM | Adipose | TRIP11 | 0.05 | 0.04 | enet | 13 | 0.02 | 3.8e-04 | -5.3 | -5.5 | 4.2e-08 | 0.01 | 0.02 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | TRIP11 | 0.04 | 0.01 | blup | 70 | 0.01 | 4.4e-02 | 3.8 | -5.5 | 4.9e-08 | 0.01 | 0.03 | 0.56 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | -3.0 | -6.1 | 8.9e-10 | -0.12 | 0.03 | 0.06 | TRUE |
| 20 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TRIP11 | 0.14 | 0.04 | blup | 70 | 0.09 | 1.6e-03 | -4.3 | -5.2 | 1.7e-07 | 0.02 | 0.03 | 0.57 | FALSE |