Best TWAS P=9.65e-11 · Best GWAS P=2.63e-09 conditioned to 0.856
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CEP192 | 0.13 | 0.13 | lasso | 6 | 0.14 | 1.1e-16 | 5.6 | 5.6 | 2.4e-08 | 0.97 | 0.04 | 0.96 | FALSE |
2 | GTEx | Adipose Subcutaneous | CEP192 | 0.38 | 0.44 | enet | 24 | 0.48 | 1.3e-44 | 5.4 | 5.4 | 8.4e-08 | 0.97 | 0.07 | 0.93 | FALSE |
3 | GTEx | Adrenal Gland | CEP192 | 0.44 | 0.56 | lasso | 2 | 0.56 | 9.6e-24 | 5.4 | 5.3 | 1.1e-07 | 0.96 | 0.07 | 0.93 | FALSE |
4 | GTEx | Artery Aorta | CEP192 | 0.43 | 0.50 | lasso | 11 | 0.55 | 2.5e-35 | 5.5 | 5.5 | 3.1e-08 | 0.97 | 0.04 | 0.96 | FALSE |
5 | GTEx | Artery Coronary | CEP192 | 0.32 | 0.35 | lasso | 5 | 0.33 | 8.2e-12 | 5.6 | 5.4 | 8.3e-08 | 0.97 | 0.03 | 0.97 | FALSE |
6 | GTEx | Artery Coronary | RP11-773H22.4 | 0.18 | 0.11 | lasso | 5 | 0.06 | 6.3e-03 | -5.6 | 5.1 | 2.7e-07 | 0.29 | 0.05 | 0.33 | FALSE |
7 | GTEx | Artery Tibial | CEP192 | 0.40 | 0.50 | enet | 29 | 0.54 | 7.3e-50 | 5.5 | 5.5 | 2.9e-08 | 0.97 | 0.04 | 0.96 | FALSE |
8 | GTEx | Brain Caudate basal ganglia | CEP192 | 0.48 | 0.36 | enet | 19 | 0.36 | 4.2e-11 | 5.6 | 5.2 | 1.7e-07 | 0.96 | 0.04 | 0.96 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | CEP192 | 0.44 | 0.20 | enet | 22 | 0.26 | 2.2e-07 | 5.7 | 6.0 | 2.4e-09 | 0.93 | 0.03 | 0.97 | FALSE |
10 | GTEx | Brain Cerebellum | CEP192 | 0.52 | 0.44 | enet | 31 | 0.52 | 5.6e-18 | 5.6 | 5.2 | 2.0e-07 | 0.92 | 0.03 | 0.97 | FALSE |
11 | GTEx | Brain Frontal Cortex BA9 | SEH1L | 0.29 | -0.01 | lasso | 4 | 0.00 | 3.0e-01 | 5.7 | 5.4 | 8.0e-08 | 0.75 | 0.04 | 0.35 | FALSE |
12 | GTEx | Brain Frontal Cortex BA9 | CEP192 | 0.27 | 0.19 | lasso | 11 | 0.18 | 1.3e-05 | 5.7 | 5.8 | 5.6e-09 | 0.93 | 0.03 | 0.96 | FALSE |
13 | GTEx | Brain Putamen basal ganglia | CEP192 | 0.50 | 0.39 | lasso | 5 | 0.36 | 2.4e-09 | 5.6 | 5.3 | 1.1e-07 | 0.95 | 0.03 | 0.97 | FALSE |
14 | GTEx | Breast Mammary Tissue | CEP192 | 0.38 | 0.40 | lasso | 4 | 0.42 | 4.7e-23 | 5.4 | 5.7 | 1.6e-08 | 0.96 | 0.03 | 0.97 | FALSE |
15 | GTEx | Breast Mammary Tissue (Male) | CEP192 | 0.58 | 0.26 | lasso | 11 | 0.30 | 1.3e-07 | 5.5 | 5.5 | 2.8e-08 | 0.95 | 0.02 | 0.97 | FALSE |
16 | GTEx | Cells EBV-transformed lymphocytes | SEH1L | 0.18 | 0.13 | lasso | 4 | 0.08 | 1.3e-03 | 5.4 | 5.4 | 7.1e-08 | 0.93 | 0.04 | 0.72 | FALSE |
17 | GTEx | Cells EBV-transformed lymphocytes | CEP192 | 0.52 | 0.34 | lasso | 5 | 0.36 | 1.6e-12 | 5.4 | 5.8 | 7.4e-09 | 0.90 | 0.03 | 0.97 | FALSE |
18 | GTEx | Cells Transformed fibroblasts | SEH1L | 0.10 | 0.03 | enet | 18 | 0.04 | 7.8e-04 | 5.7 | 5.8 | 6.5e-09 | 0.63 | 0.03 | 0.95 | FALSE |
19 | GTEx | Cells Transformed fibroblasts | CEP192 | 0.32 | 0.32 | enet | 39 | 0.39 | 2.7e-31 | 5.6 | 5.5 | 3.0e-08 | 0.93 | 0.03 | 0.97 | FALSE |
20 | GTEx | Colon Transverse | CEP192 | 0.45 | 0.54 | lasso | 8 | 0.57 | 1.2e-32 | 5.4 | 5.2 | 2.3e-07 | 0.96 | 0.05 | 0.95 | FALSE |
21 | GTEx | Esophagus Gastroesophageal Junction | CEP192 | 0.38 | 0.39 | lasso | 4 | 0.39 | 4.7e-15 | 5.4 | 5.5 | 2.9e-08 | 0.97 | 0.04 | 0.96 | FALSE |
22 | GTEx | Esophagus Mucosa | SEH1L | 0.09 | 0.02 | enet | 25 | 0.03 | 2.4e-03 | -5.6 | 5.8 | 4.8e-09 | 0.47 | 0.04 | 0.89 | FALSE |
23 | GTEx | Esophagus Mucosa | CEP192 | 0.39 | 0.51 | enet | 29 | 0.52 | 7.4e-40 | 5.5 | 5.3 | 1.1e-07 | 0.97 | 0.04 | 0.96 | FALSE |
24 | GTEx | Esophagus Muscularis | CEP192 | 0.39 | 0.46 | lasso | 9 | 0.52 | 2.1e-36 | 5.6 | 5.2 | 2.0e-07 | 0.97 | 0.04 | 0.96 | FALSE |
25 | GTEx | Heart Atrial Appendage | CEP192 | 0.29 | 0.28 | lasso | 5 | 0.26 | 4.3e-12 | 5.4 | 5.2 | 2.6e-07 | 0.95 | 0.03 | 0.97 | FALSE |
26 | GTEx | Lung | CEP192 | 0.32 | 0.29 | lasso | 7 | 0.34 | 3.8e-27 | 5.4 | 5.4 | 5.2e-08 | 0.96 | 0.04 | 0.96 | FALSE |
27 | GTEx | Muscle Skeletal | CEP192 | 0.10 | 0.07 | lasso | 3 | 0.07 | 3.1e-07 | 5.4 | 5.2 | 1.9e-07 | 0.95 | 0.03 | 0.97 | FALSE |
28 | GTEx | Nerve Tibial | CEP192 | 0.44 | 0.52 | lasso | 12 | 0.55 | 3.1e-46 | 5.6 | 5.4 | 7.4e-08 | 0.97 | 0.04 | 0.96 | FALSE |
29 | GTEx | Ovary | CEP192 | 0.43 | 0.42 | enet | 25 | 0.43 | 6.5e-12 | 5.4 | 5.5 | 3.3e-08 | 0.97 | 0.02 | 0.98 | FALSE |
30 | GTEx | Pituitary | SEH1L | 0.22 | 0.07 | lasso | 6 | 0.05 | 2.1e-02 | -5.6 | 5.2 | 1.7e-07 | 0.35 | 0.06 | 0.30 | FALSE |
31 | GTEx | Prostate | CEP192 | 0.57 | 0.59 | enet | 23 | 0.66 | 1.8e-21 | 5.5 | 5.4 | 8.3e-08 | 0.96 | 0.03 | 0.97 | FALSE |
32 | GTEx | Skin Not Sun Exposed Suprapubic | CEP192 | 0.34 | 0.35 | enet | 20 | 0.40 | 1.6e-23 | 5.6 | 5.1 | 3.0e-07 | 0.96 | 0.03 | 0.97 | FALSE |
33 | GTEx | Skin Sun Exposed Lower leg | CEP192 | 0.34 | 0.36 | lasso | 3 | 0.38 | 3.5e-33 | 5.4 | 5.5 | 5.1e-08 | 0.97 | 0.08 | 0.92 | FALSE |
34 | GTEx | Spleen | CEP192 | 0.54 | 0.52 | lasso | 5 | 0.49 | 2.8e-14 | 5.4 | 5.4 | 5.7e-08 | 0.97 | 0.04 | 0.96 | FALSE |
35 | GTEx | Stomach | CEP192 | 0.37 | 0.44 | lasso | 5 | 0.43 | 1.5e-22 | 5.4 | 5.6 | 2.5e-08 | 0.96 | 0.05 | 0.95 | FALSE |
36 | GTEx | Thyroid | CEP192 | 0.37 | 0.48 | lasso | 7 | 0.52 | 3.2e-46 | 5.5 | 5.6 | 2.6e-08 | 0.97 | 0.04 | 0.96 | FALSE |
37 | GTEx | Uterus | CEP192 | 0.52 | 0.43 | lasso | 6 | 0.41 | 1.7e-09 | 5.4 | 5.5 | 3.8e-08 | 0.96 | 0.03 | 0.97 | FALSE |
38 | GTEx | Vagina | CEP192 | 0.51 | 0.31 | lasso | 4 | 0.37 | 2.3e-09 | 5.4 | 5.3 | 1.2e-07 | 0.94 | 0.03 | 0.97 | FALSE |
39 | GTEx | Whole Blood | CEP192 | 0.17 | 0.16 | enet | 15 | 0.17 | 3.7e-15 | 5.4 | 5.3 | 8.7e-08 | 0.97 | 0.04 | 0.96 | FALSE |
40 | METSIM | Adipose | CEP192 | 0.19 | 0.32 | lasso | 5 | 0.32 | 1.0e-48 | 5.4 | 5.3 | 1.4e-07 | 0.96 | 0.05 | 0.95 | FALSE |
41 | METSIM | Adipose | CEP76 | 0.04 | 0.00 | bslmm | 395 | 0.01 | 1.8e-02 | 2.5 | 5.3 | 9.0e-08 | 0.31 | 0.24 | 0.03 | FALSE |
42 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CEP192 | 0.07 | 0.09 | lasso | 2 | 0.09 | 9.4e-08 | 6.0 | 6.0 | 2.7e-09 | 1.00 | 0.01 | 0.99 | FALSE |
43 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CEP192 | 0.06 | 0.13 | enet | 9 | 0.13 | 3.4e-26 | 5.5 | 5.8 | 8.9e-09 | 0.97 | 0.03 | 0.97 | FALSE |
44 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CEP192 | 0.16 | 0.20 | lasso | 4 | 0.19 | 1.6e-09 | 5.6 | 5.6 | 1.8e-08 | 0.98 | 0.02 | 0.98 | FALSE |
45 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP192 | 0.06 | 0.05 | blup | 84 | 0.04 | 1.5e-03 | 5.7 | 6.5 | 9.7e-11 | 0.93 | 0.02 | 0.93 | TRUE |
46 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CEP192 | 0.21 | 0.31 | lasso | 4 | 0.31 | 1.0e-35 | 5.5 | 5.3 | 9.1e-08 | 0.97 | 0.04 | 0.96 | FALSE |
47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SEH1L | 0.03 | 0.01 | blup | 60 | 0.01 | 4.0e-02 | -5.4 | 5.9 | 3.5e-09 | 0.70 | 0.01 | 0.47 | FALSE |
48 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CEP192 | 0.30 | 0.33 | lasso | 2 | 0.33 | 1.8e-19 | 5.4 | 5.3 | 1.0e-07 | 0.95 | 0.05 | 0.95 | FALSE |
49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CEP192 | 0.27 | 0.38 | blup | 84 | 0.38 | 1.5e-45 | 5.6 | 5.2 | 1.5e-07 | 0.95 | 0.04 | 0.96 | FALSE |
50 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SEH1L | 0.05 | 0.00 | blup | 60 | 0.01 | 1.0e-02 | 5.4 | 5.6 | 1.7e-08 | 0.74 | 0.01 | 0.49 | FALSE |
51 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CEP192 | 0.11 | 0.16 | lasso | 3 | 0.16 | 7.6e-08 | 6.0 | 6.0 | 1.5e-09 | 0.99 | 0.02 | 0.98 | FALSE |
52 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CEP192 | 0.09 | 0.07 | blup | 84 | 0.09 | 2.1e-06 | 5.2 | 5.3 | 1.4e-07 | 0.92 | 0.04 | 0.96 | FALSE |
53 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CEP192 | 0.12 | 0.06 | blup | 84 | 0.08 | 2.0e-04 | 4.6 | 6.1 | 9.1e-10 | 0.95 | 0.03 | 0.96 | FALSE |
54 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CEP192 | 0.33 | 0.49 | lasso | 5 | 0.49 | 1.0e-57 | 5.6 | 5.6 | 1.8e-08 | 0.98 | 0.02 | 0.98 | FALSE |
55 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CEP192 | 0.10 | 0.07 | blup | 84 | 0.08 | 1.2e-05 | 5.4 | 5.3 | 1.1e-07 | 0.96 | 0.04 | 0.96 | FALSE |
56 | The Cancer Genome Atlas | Thyroid Carcinoma | CEP192 | 0.36 | 0.53 | enet | 19 | 0.54 | 2.6e-61 | 5.5 | 5.5 | 4.8e-08 | 0.98 | 0.02 | 0.98 | FALSE |