Best TWAS P=1.38e-20 · Best GWAS P=4.69e-23 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DCAKD | 0.18 | 0.20 | lasso | 6 | 0.20 | 2.6e-23 | -5.17 | 5.2 | 2.1e-07 | -0.44 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | NMT1 | 0.19 | 0.10 | lasso | 6 | 0.10 | 1.1e-08 | 5.46 | -5.5 | 4.0e-08 | 0.32 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | DCAKD | 0.21 | 0.09 | lasso | 6 | 0.14 | 6.1e-12 | 6.51 | 7.3 | 3.1e-13 | -0.35 | 1.00 | 0.00 | FALSE |
4 | GTEx | Adipose Subcutaneous | ACBD4 | 0.10 | 0.06 | enet | 8 | 0.06 | 1.8e-05 | -7.74 | -8.8 | 1.4e-18 | 0.52 | 0.53 | 0.35 | TRUE |
5 | GTEx | Adrenal Gland | PLEKHM1 | 0.21 | 0.00 | enet | 20 | 0.08 | 1.0e-03 | 5.10 | 6.6 | 4.4e-11 | -0.13 | 0.08 | 0.13 | FALSE |
6 | GTEx | Artery Aorta | NMT1 | 0.14 | 0.08 | lasso | 2 | 0.12 | 3.9e-07 | -5.77 | -6.9 | 6.5e-12 | 0.50 | 0.89 | 0.08 | FALSE |
7 | GTEx | Artery Aorta | DCAKD | 0.22 | 0.16 | enet | 26 | 0.19 | 1.1e-10 | -5.17 | 8.4 | 5.2e-17 | -0.46 | 0.92 | 0.06 | TRUE |
8 | GTEx | Artery Aorta | GJC1 | 0.24 | 0.16 | lasso | 6 | 0.14 | 2.2e-08 | 5.21 | 5.8 | 7.6e-09 | -0.02 | 1.00 | 0.00 | FALSE |
9 | GTEx | Artery Coronary | NMT1 | 0.13 | 0.06 | enet | 7 | 0.11 | 1.5e-04 | 6.68 | -8.1 | 7.2e-16 | 0.53 | 0.11 | 0.33 | FALSE |
10 | GTEx | Artery Tibial | NMT1 | 0.11 | 0.09 | lasso | 5 | 0.10 | 6.3e-08 | -5.88 | -7.3 | 3.9e-13 | 0.36 | 0.96 | 0.03 | FALSE |
11 | GTEx | Artery Tibial | DCAKD | 0.27 | 0.21 | lasso | 8 | 0.20 | 6.6e-16 | -5.17 | 6.2 | 6.8e-10 | -0.43 | 1.00 | 0.00 | FALSE |
12 | GTEx | Artery Tibial | ACBD4 | 0.10 | 0.09 | lasso | 2 | 0.08 | 4.8e-07 | -7.78 | -7.8 | 6.3e-15 | 0.58 | 0.81 | 0.12 | FALSE |
13 | GTEx | Artery Tibial | HEXIM1 | 0.13 | 0.08 | lasso | 2 | 0.05 | 1.8e-04 | 6.58 | 6.6 | 4.9e-11 | -0.58 | 0.72 | 0.25 | FALSE |
14 | GTEx | Brain Cerebellar Hemisphere | DCAKD | 0.37 | 0.22 | lasso | 6 | 0.21 | 5.1e-06 | -5.07 | 5.2 | 1.5e-07 | -0.46 | 0.77 | 0.10 | FALSE |
15 | GTEx | Brain Cerebellar Hemisphere | ACBD4 | 0.43 | 0.12 | lasso | 8 | 0.18 | 1.7e-05 | -7.25 | -6.8 | 9.1e-12 | 0.37 | 0.11 | 0.42 | FALSE |
16 | GTEx | Brain Cerebellar Hemisphere | FMNL1 | 0.27 | 0.03 | enet | 17 | 0.09 | 2.2e-03 | 0.94 | -5.5 | 3.9e-08 | 0.28 | 0.04 | 0.08 | FALSE |
17 | GTEx | Brain Cerebellar Hemisphere | CTD-2020K17.4 | 0.23 | 0.02 | enet | 20 | 0.11 | 1.1e-03 | -7.19 | -7.1 | 1.2e-12 | 0.46 | 0.03 | 0.16 | FALSE |
18 | GTEx | Brain Cerebellum | ADAM11 | 0.17 | 0.19 | enet | 8 | 0.18 | 4.4e-06 | 4.20 | 5.7 | 1.5e-08 | -0.13 | 0.48 | 0.03 | FALSE |
19 | GTEx | Brain Cerebellum | DCAKD | 0.40 | 0.06 | enet | 20 | 0.24 | 1.4e-07 | -5.11 | 6.8 | 1.4e-11 | -0.39 | 0.80 | 0.06 | FALSE |
20 | GTEx | Brain Cerebellum | ACBD4 | 0.40 | 0.06 | lasso | 8 | 0.17 | 1.0e-05 | 7.05 | -6.8 | 7.8e-12 | 0.27 | 0.09 | 0.14 | FALSE |
21 | GTEx | Brain Frontal Cortex BA9 | DCAKD | 0.41 | 0.08 | enet | 23 | 0.10 | 1.2e-03 | -5.07 | 5.5 | 3.7e-08 | -0.41 | 0.24 | 0.06 | FALSE |
22 | GTEx | Brain Hippocampus | CCDC43 | 0.23 | 0.09 | enet | 9 | 0.16 | 1.8e-04 | -7.25 | 6.4 | 2.0e-10 | -0.46 | 0.05 | 0.29 | FALSE |
23 | GTEx | Breast Mammary Tissue | KANSL1 | 0.31 | 0.00 | enet | 9 | 0.11 | 2.6e-06 | 2.41 | -6.0 | 2.5e-09 | 0.08 | 0.00 | 0.00 | TRUE |
24 | GTEx | Breast Mammary Tissue | PLCD3 | 0.18 | 0.08 | enet | 18 | 0.14 | 1.5e-07 | -7.19 | 5.3 | 1.4e-07 | -0.29 | 0.56 | 0.02 | FALSE |
25 | GTEx | Breast Mammary Tissue | DCAKD | 0.16 | 0.13 | lasso | 7 | 0.13 | 2.9e-07 | -6.51 | 6.4 | 1.6e-10 | -0.59 | 0.92 | 0.07 | FALSE |
26 | GTEx | Breast Mammary Tissue (Male) | DCAKD | 0.36 | 0.29 | lasso | 8 | 0.33 | 1.4e-08 | -5.11 | 6.9 | 5.8e-12 | -0.58 | 0.42 | 0.43 | FALSE |
27 | GTEx | Breast Mammary Tissue (Female) | PLCD3 | 0.15 | 0.14 | enet | 12 | 0.12 | 2.1e-04 | -7.25 | 5.5 | 4.2e-08 | -0.32 | 0.10 | 0.05 | FALSE |
28 | GTEx | Breast Mammary Tissue (Female) | FZD2 | 0.10 | 0.08 | lasso | 2 | 0.05 | 1.1e-02 | 5.77 | 5.9 | 3.3e-09 | -0.07 | 0.05 | 0.07 | FALSE |
29 | GTEx | Cells EBV-transformed lymphocytes | GJC1 | 0.34 | 0.33 | lasso | 4 | 0.33 | 2.3e-11 | 5.21 | 5.4 | 7.2e-08 | 0.01 | 1.00 | 0.00 | FALSE |
30 | GTEx | Cells Transformed fibroblasts | PLCD3 | 0.23 | 0.04 | lasso | 5 | 0.08 | 1.3e-06 | 2.36 | 6.2 | 4.1e-10 | -0.48 | 0.95 | 0.01 | FALSE |
31 | GTEx | Cells Transformed fibroblasts | GJC1 | 0.41 | 0.40 | enet | 32 | 0.44 | 8.7e-36 | 5.16 | 5.4 | 8.0e-08 | -0.02 | 1.00 | 0.00 | FALSE |
32 | GTEx | Cells Transformed fibroblasts | HEXIM1 | 0.11 | 0.10 | lasso | 2 | 0.08 | 1.6e-06 | 6.58 | 6.6 | 4.0e-11 | -0.58 | 0.65 | 0.30 | FALSE |
33 | GTEx | Colon Sigmoid | DCAKD | 0.18 | 0.16 | lasso | 3 | 0.16 | 2.1e-06 | -5.17 | 5.6 | 2.6e-08 | -0.44 | 0.63 | 0.12 | FALSE |
34 | GTEx | Colon Transverse | DCAKD | 0.28 | 0.18 | lasso | 8 | 0.26 | 1.5e-12 | -5.11 | 6.8 | 1.1e-11 | -0.41 | 0.99 | 0.00 | FALSE |
35 | GTEx | Esophagus Gastroesophageal Junction | NMT1 | 0.24 | 0.21 | lasso | 4 | 0.22 | 2.8e-08 | 5.46 | -8.1 | 5.9e-16 | 0.54 | 0.35 | 0.63 | TRUE |
36 | GTEx | Esophagus Gastroesophageal Junction | DCAKD | 0.42 | 0.36 | lasso | 7 | 0.37 | 3.8e-14 | -6.51 | 6.7 | 1.6e-11 | -0.58 | 0.97 | 0.03 | FALSE |
37 | GTEx | Esophagus Mucosa | ADAM11 | 0.19 | 0.14 | lasso | 4 | 0.12 | 1.2e-08 | 5.73 | 5.8 | 7.3e-09 | -0.07 | 0.99 | 0.00 | FALSE |
38 | GTEx | Esophagus Mucosa | DCAKD | 0.33 | 0.32 | enet | 20 | 0.35 | 5.6e-24 | -5.17 | 6.5 | 8.4e-11 | -0.51 | 1.00 | 0.00 | TRUE |
39 | GTEx | Esophagus Mucosa | ACBD4 | 0.14 | 0.10 | lasso | 4 | 0.10 | 4.5e-07 | 6.99 | -7.4 | 1.3e-13 | 0.13 | 0.59 | 0.08 | FALSE |
40 | GTEx | Esophagus Muscularis | NMT1 | 0.13 | 0.12 | lasso | 2 | 0.14 | 1.5e-08 | 5.46 | -6.0 | 1.8e-09 | 0.36 | 0.97 | 0.02 | FALSE |
41 | GTEx | Esophagus Muscularis | DCAKD | 0.27 | 0.29 | lasso | 5 | 0.30 | 2.1e-18 | -5.17 | 6.0 | 1.9e-09 | -0.47 | 1.00 | 0.00 | FALSE |
42 | GTEx | Heart Left Ventricle | DCAKD | 0.17 | 0.17 | lasso | 3 | 0.17 | 2.3e-09 | -5.17 | 6.6 | 3.6e-11 | -0.55 | 0.98 | 0.01 | FALSE |
43 | GTEx | Lung | HIGD1B | 0.09 | 0.04 | lasso | 3 | 0.04 | 2.2e-04 | 5.81 | -5.6 | 1.9e-08 | -0.01 | 0.78 | 0.01 | FALSE |
44 | GTEx | Lung | DCAKD | 0.22 | 0.05 | enet | 27 | 0.10 | 5.2e-08 | 5.45 | 6.3 | 2.8e-10 | -0.44 | 0.96 | 0.02 | FALSE |
45 | GTEx | Muscle Skeletal | PLCD3 | 0.18 | 0.10 | enet | 8 | 0.10 | 1.7e-10 | 6.99 | 7.3 | 2.1e-13 | -0.12 | 1.00 | 0.00 | FALSE |
46 | GTEx | Muscle Skeletal | DCAKD | 0.12 | 0.06 | enet | 16 | 0.07 | 9.9e-08 | -6.51 | 7.4 | 1.3e-13 | -0.54 | 0.89 | 0.11 | FALSE |
47 | GTEx | Nerve Tibial | NMT1 | 0.16 | 0.14 | lasso | 6 | 0.11 | 2.0e-08 | 5.46 | -5.4 | 8.3e-08 | 0.33 | 1.00 | 0.00 | FALSE |
48 | GTEx | Nerve Tibial | DCAKD | 0.35 | 0.29 | enet | 21 | 0.30 | 1.6e-21 | 5.51 | 6.6 | 3.6e-11 | -0.42 | 1.00 | 0.00 | FALSE |
49 | GTEx | Nerve Tibial | ACBD4 | 0.21 | 0.10 | lasso | 5 | 0.11 | 4.2e-08 | -7.25 | -8.8 | 1.4e-18 | 0.47 | 0.93 | 0.07 | FALSE |
50 | GTEx | Pancreas | NMT1 | 0.19 | 0.12 | enet | 18 | 0.07 | 8.0e-04 | -5.77 | -6.0 | 2.6e-09 | 0.27 | 0.32 | 0.13 | FALSE |
51 | GTEx | Prostate | NMT1 | 0.43 | 0.28 | lasso | 6 | 0.25 | 5.3e-07 | 5.64 | -6.1 | 1.4e-09 | 0.36 | 0.58 | 0.12 | FALSE |
52 | GTEx | Skin Not Sun Exposed Suprapubic | DCAKD | 0.30 | 0.21 | lasso | 6 | 0.20 | 5.0e-11 | -6.51 | 7.1 | 1.0e-12 | -0.58 | 1.00 | 0.00 | FALSE |
53 | GTEx | Skin Sun Exposed Lower leg | DCAKD | 0.33 | 0.20 | enet | 30 | 0.31 | 2.4e-26 | -5.17 | 6.6 | 3.3e-11 | -0.27 | 1.00 | 0.00 | FALSE |
54 | GTEx | Skin Sun Exposed Lower leg | ACBD4 | 0.06 | 0.05 | lasso | 4 | 0.02 | 3.8e-03 | 7.05 | -8.8 | 1.1e-18 | 0.33 | 0.19 | 0.08 | FALSE |
55 | GTEx | Stomach | DCAKD | 0.29 | 0.17 | enet | 25 | 0.20 | 9.4e-10 | -5.17 | 7.4 | 1.0e-13 | -0.48 | 0.58 | 0.41 | FALSE |
56 | GTEx | Thyroid | NMT1 | 0.09 | 0.09 | lasso | 2 | 0.08 | 8.1e-07 | 5.46 | -5.6 | 2.5e-08 | 0.32 | 0.95 | 0.02 | FALSE |
57 | GTEx | Thyroid | PLCD3 | 0.12 | 0.01 | enet | 20 | 0.07 | 8.2e-06 | 6.99 | 6.3 | 2.8e-10 | -0.04 | 0.77 | 0.01 | FALSE |
58 | GTEx | Thyroid | DCAKD | 0.25 | 0.26 | enet | 17 | 0.27 | 9.4e-21 | -6.51 | 6.3 | 2.3e-10 | -0.57 | 1.00 | 0.00 | FALSE |
59 | GTEx | Thyroid | ACBD4 | 0.20 | 0.16 | enet | 23 | 0.15 | 1.2e-11 | -7.74 | -9.3 | 1.4e-20 | 0.51 | 1.00 | 0.00 | TRUE |
60 | GTEx | Whole Blood | DCAKD | 0.07 | 0.08 | lasso | 2 | 0.06 | 1.8e-06 | -5.17 | 5.8 | 9.1e-09 | -0.52 | 0.95 | 0.03 | FALSE |
61 | METSIM | Adipose | C17orf104 | 0.05 | 0.02 | bslmm | 404 | 0.04 | 4.2e-06 | 4.71 | -5.9 | 3.7e-09 | 0.11 | 0.91 | 0.00 | FALSE |
62 | METSIM | Adipose | NMT1 | 0.13 | 0.11 | lasso | 6 | 0.11 | 5.7e-16 | -5.40 | -5.7 | 1.6e-08 | 0.47 | 1.00 | 0.00 | FALSE |
63 | YFS | Blood | DCAKD | 0.26 | 0.24 | enet | 47 | 0.27 | 1.3e-88 | -5.17 | 5.7 | 1.4e-08 | -0.43 | 1.00 | 0.00 | FALSE |
64 | YFS | Blood | FZD2 | 0.15 | 0.12 | bslmm | 362 | 0.13 | 1.8e-39 | 5.75 | 5.4 | 7.7e-08 | -0.08 | 0.83 | 0.17 | FALSE |
65 | YFS | Blood | HEXIM2 | 0.02 | 0.01 | bslmm | 279 | 0.01 | 1.0e-05 | 6.68 | -7.0 | 1.8e-12 | 0.61 | 0.49 | 0.47 | FALSE |
66 | YFS | Blood | NMT1 | 0.02 | 0.01 | lasso | 6 | 0.01 | 5.0e-03 | 6.97 | -8.0 | 1.7e-15 | 0.37 | 0.28 | 0.05 | FALSE |
67 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | LOC644172 | 0.08 | 0.00 | blup | 79 | 0.04 | 3.2e-04 | 3.33 | 6.0 | 1.5e-09 | -0.51 | 0.07 | 0.27 | FALSE |
68 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DCAKD | 0.04 | 0.02 | lasso | 4 | 0.02 | 6.3e-06 | -6.51 | 5.6 | 1.9e-08 | -0.55 | 0.22 | 0.77 | FALSE |
69 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC644172 | 0.14 | 0.07 | enet | 10 | 0.12 | 1.2e-23 | 1.41 | 5.6 | 1.8e-08 | -0.35 | 1.00 | 0.00 | FALSE |
70 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MGC57346 | 0.02 | 0.00 | blup | 62 | 0.02 | 2.2e-05 | 1.57 | 5.6 | 1.7e-08 | -0.53 | 0.04 | 0.58 | FALSE |
71 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LOC644172 | 0.19 | -0.01 | blup | 81 | 0.03 | 1.3e-02 | 1.57 | 6.3 | 2.2e-10 | -0.47 | 0.02 | 0.56 | FALSE |
72 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DCAKD | 0.07 | 0.07 | lasso | 4 | 0.07 | 1.4e-08 | -6.51 | 7.9 | 3.8e-15 | -0.56 | 0.09 | 0.91 | FALSE |
73 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DCAKD | 0.03 | 0.04 | lasso | 2 | 0.03 | 3.8e-04 | -5.51 | 5.7 | 1.2e-08 | -0.43 | 0.27 | 0.32 | FALSE |
74 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NMT1 | 0.05 | 0.04 | lasso | 2 | 0.04 | 1.5e-05 | -5.88 | -5.9 | 2.9e-09 | 0.39 | 0.81 | 0.02 | FALSE |
75 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ACBD4 | 0.08 | 0.04 | enet | 9 | 0.04 | 6.9e-06 | -7.74 | -7.5 | 5.3e-14 | 0.50 | 0.95 | 0.01 | FALSE |
76 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC644172 | 0.04 | 0.00 | enet | 15 | 0.02 | 4.0e-03 | -9.89 | 6.7 | 2.7e-11 | -0.60 | 0.00 | 0.75 | FALSE |
77 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NMT1 | 0.08 | 0.04 | blup | 83 | 0.05 | 3.5e-06 | -5.17 | -6.3 | 3.1e-10 | 0.37 | 0.96 | 0.02 | FALSE |
78 | The Cancer Genome Atlas | Lung Adenocarcinoma | DCAKD | 0.03 | 0.03 | lasso | 3 | 0.04 | 3.2e-05 | 5.16 | 5.5 | 4.4e-08 | -0.39 | 0.46 | 0.12 | FALSE |
79 | The Cancer Genome Atlas | Lung Adenocarcinoma | NMT1 | 0.04 | 0.00 | blup | 81 | 0.01 | 1.9e-02 | -5.77 | -7.6 | 3.4e-14 | 0.27 | 0.03 | 0.70 | FALSE |
80 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLCD3 | 0.04 | 0.01 | blup | 64 | 0.01 | 2.3e-02 | 6.99 | -6.9 | 4.7e-12 | 0.27 | 0.05 | 0.08 | FALSE |
81 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DCAKD | 0.04 | 0.02 | blup | 66 | 0.02 | 3.5e-03 | -5.54 | 5.7 | 9.3e-09 | -0.48 | 0.25 | 0.36 | FALSE |
82 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HEXIM1 | 0.06 | 0.01 | blup | 47 | 0.03 | 3.3e-03 | 3.06 | 6.2 | 6.3e-10 | -0.24 | 0.01 | 0.13 | FALSE |
83 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NMT1 | 0.23 | 0.08 | blup | 82 | 0.12 | 1.1e-05 | 5.51 | -8.1 | 6.7e-16 | 0.55 | 0.05 | 0.90 | FALSE |
84 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ACBD4 | 0.04 | 0.01 | enet | 7 | 0.03 | 2.2e-04 | 5.10 | -7.5 | 6.2e-14 | 0.44 | 0.09 | 0.16 | FALSE |
85 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC644172 | 0.15 | 0.01 | blup | 77 | 0.06 | 1.0e-06 | 6.97 | 6.6 | 3.4e-11 | -0.40 | 0.19 | 0.28 | FALSE |
86 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NMT1 | 0.09 | 0.08 | lasso | 3 | 0.09 | 1.1e-09 | 5.51 | -6.3 | 3.0e-10 | 0.46 | 0.91 | 0.09 | FALSE |
87 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LOC644172 | 0.17 | 0.00 | enet | 16 | 0.06 | 1.9e-05 | 1.41 | 5.5 | 5.1e-08 | -0.32 | 0.17 | 0.07 | FALSE |
88 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LOC644172 | 0.20 | 0.01 | enet | 12 | 0.06 | 4.5e-03 | -3.83 | 5.9 | 3.7e-09 | -0.47 | 0.06 | 0.08 | FALSE |
89 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAKD | 0.12 | 0.13 | lasso | 8 | 0.13 | 5.5e-13 | -5.17 | 5.5 | 4.9e-08 | -0.47 | 0.97 | 0.03 | FALSE |
90 | The Cancer Genome Atlas | Thyroid Carcinoma | GFAP | 0.09 | 0.05 | lasso | 2 | 0.04 | 3.4e-05 | 5.15 | -5.3 | 1.4e-07 | -0.01 | 0.31 | 0.37 | FALSE |
91 | The Cancer Genome Atlas | Thyroid Carcinoma | HEXIM1 | 0.05 | 0.05 | blup | 47 | 0.04 | 8.5e-05 | -9.89 | 9.2 | 2.3e-20 | -0.84 | 0.00 | 1.00 | FALSE |
92 | The Cancer Genome Atlas | Thyroid Carcinoma | NMT1 | 0.18 | 0.19 | enet | 20 | 0.20 | 3.8e-19 | -5.77 | -6.5 | 7.7e-11 | 0.40 | 1.00 | 0.00 | FALSE |
93 | The Cancer Genome Atlas | Thyroid Carcinoma | PLCD3 | 0.24 | 0.16 | lasso | 5 | 0.20 | 2.8e-19 | 6.99 | 7.6 | 2.2e-14 | -0.15 | 1.00 | 0.00 | FALSE |