Best TWAS P=4.91e-20 · Best GWAS P=2.2e-20 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -1.22 | 5.5 | 3.7e-08 | -0.20 | 0.28 | 0.03 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | UBXN6 | 0.27 | 0.25 | enet | 28 | 0.29 | 4.6e-36 | 4.82 | -6.1 | 1.4e-09 | -0.05 | 0.09 | 0.91 | FALSE |
3 | GTEx | Adipose Subcutaneous | AMH | 0.18 | 0.05 | lasso | 8 | 0.06 | 1.9e-05 | -3.47 | 5.2 | 1.6e-07 | -0.22 | 0.92 | 0.01 | FALSE |
4 | GTEx | Adipose Visceral Omentum | NFIC | 0.20 | 0.00 | lasso | 5 | 0.02 | 2.2e-02 | 5.39 | -5.3 | 1.1e-07 | 0.07 | 0.07 | 0.14 | FALSE |
5 | GTEx | Adipose Visceral Omentum | CHAF1A | 0.24 | 0.26 | lasso | 3 | 0.26 | 6.2e-14 | 5.37 | -5.3 | 1.2e-07 | -0.04 | 0.01 | 0.99 | FALSE |
6 | GTEx | Adrenal Gland | CHAF1A | 0.22 | 0.18 | lasso | 3 | 0.17 | 1.1e-06 | 4.81 | -5.1 | 2.9e-07 | -0.04 | 0.02 | 0.97 | FALSE |
7 | GTEx | Artery Aorta | UBXN6 | 0.13 | 0.02 | lasso | 5 | 0.03 | 5.7e-03 | -4.72 | -6.0 | 1.4e-09 | -0.03 | 0.06 | 0.88 | FALSE |
8 | GTEx | Artery Aorta | CTB-50L17.5 | 0.16 | 0.15 | lasso | 7 | 0.15 | 1.0e-08 | 5.59 | -5.5 | 4.9e-08 | -0.03 | 0.02 | 0.98 | FALSE |
9 | GTEx | Artery Coronary | CTB-50L17.9 | 0.43 | 0.14 | lasso | 6 | 0.12 | 6.5e-05 | 4.91 | -5.2 | 2.3e-07 | -0.01 | 0.12 | 0.48 | FALSE |
10 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | 8.78 | 8.3 | 1.5e-16 | -0.89 | 0.03 | 0.97 | TRUE |
11 | GTEx | Artery Tibial | NFIC | 0.14 | 0.13 | enet | 11 | 0.12 | 7.6e-10 | 5.39 | -5.6 | 2.6e-08 | 0.02 | 0.86 | 0.14 | TRUE |
12 | GTEx | Artery Tibial | UBXN6 | 0.18 | 0.07 | lasso | 3 | 0.14 | 6.3e-11 | 5.83 | -6.2 | 4.1e-10 | -0.05 | 0.01 | 0.99 | FALSE |
13 | GTEx | Artery Tibial | AC005306.3 | 0.25 | 0.12 | enet | 59 | 0.11 | 3.9e-09 | -2.35 | -5.2 | 1.7e-07 | 0.16 | 1.00 | 0.00 | TRUE |
14 | GTEx | Brain Caudate basal ganglia | CTB-50L17.9 | 0.27 | 0.25 | lasso | 2 | 0.24 | 1.8e-07 | 5.59 | -5.6 | 1.9e-08 | -0.03 | 0.03 | 0.92 | FALSE |
15 | GTEx | Brain Cerebellar Hemisphere | CHAF1A | 0.62 | 0.40 | lasso | 8 | 0.36 | 3.5e-10 | 5.59 | -5.5 | 3.0e-08 | -0.04 | 0.02 | 0.98 | FALSE |
16 | GTEx | Brain Cerebellum | CHAF1A | 0.51 | 0.35 | lasso | 4 | 0.34 | 9.7e-11 | 5.59 | -5.5 | 3.6e-08 | -0.03 | 0.02 | 0.98 | FALSE |
17 | GTEx | Brain Cerebellum | CTB-50L17.9 | 0.53 | 0.41 | lasso | 2 | 0.50 | 3.6e-17 | 4.91 | -5.5 | 4.0e-08 | -0.04 | 0.06 | 0.94 | FALSE |
18 | GTEx | Brain Frontal Cortex BA9 | UBXN6 | 0.31 | 0.06 | enet | 5 | 0.12 | 3.5e-04 | 4.91 | -5.3 | 1.2e-07 | -0.05 | 0.04 | 0.79 | FALSE |
19 | GTEx | Brain Frontal Cortex BA9 | CTB-50L17.9 | 0.27 | 0.21 | lasso | 3 | 0.19 | 7.9e-06 | 4.91 | -5.4 | 6.4e-08 | -0.04 | 0.07 | 0.87 | FALSE |
20 | GTEx | Brain Frontal Cortex BA9 | AC007292.6 | 0.35 | 0.01 | lasso | 6 | 0.12 | 3.6e-04 | -0.16 | -5.4 | 7.7e-08 | 0.02 | 0.02 | 0.69 | FALSE |
21 | GTEx | Brain Nucleus accumbens basal ganglia | CHAF1A | 0.31 | 0.28 | lasso | 2 | 0.24 | 4.0e-07 | 5.37 | -5.4 | 8.2e-08 | -0.03 | 0.02 | 0.97 | FALSE |
22 | GTEx | Brain Nucleus accumbens basal ganglia | CTB-50L17.9 | 0.45 | 0.25 | lasso | 8 | 0.23 | 8.6e-07 | 5.59 | -6.2 | 6.1e-10 | -0.02 | 0.06 | 0.91 | FALSE |
23 | GTEx | Breast Mammary Tissue (Female) | CHAF1A | 0.33 | 0.14 | lasso | 6 | 0.09 | 1.6e-03 | 5.37 | -5.2 | 2.2e-07 | -0.04 | 0.03 | 0.91 | FALSE |
24 | GTEx | Colon Sigmoid | CHAF1A | 0.33 | 0.08 | lasso | 5 | 0.12 | 7.5e-05 | 5.37 | -5.2 | 2.3e-07 | -0.03 | 0.02 | 0.96 | FALSE |
25 | GTEx | Colon Sigmoid | UBXN6 | 0.34 | 0.15 | lasso | 6 | 0.14 | 1.7e-05 | 4.91 | -5.7 | 1.2e-08 | -0.03 | 0.08 | 0.89 | FALSE |
26 | GTEx | Esophagus Muscularis | UBXN6 | 0.35 | 0.24 | enet | 20 | 0.29 | 3.7e-18 | 4.91 | -5.5 | 3.3e-08 | -0.03 | 0.04 | 0.96 | FALSE |
27 | GTEx | Heart Atrial Appendage | UBXN6 | 0.34 | 0.12 | lasso | 6 | 0.21 | 6.5e-10 | 5.59 | -5.8 | 5.1e-09 | -0.03 | 0.08 | 0.92 | FALSE |
28 | GTEx | Heart Left Ventricle | CHAF1A | 0.17 | 0.12 | lasso | 2 | 0.11 | 1.9e-06 | 5.59 | -5.6 | 2.0e-08 | -0.04 | 0.01 | 0.99 | FALSE |
29 | GTEx | Heart Left Ventricle | UBXN6 | 0.21 | 0.14 | lasso | 6 | 0.16 | 5.6e-09 | -4.79 | -5.6 | 1.9e-08 | -0.03 | 0.44 | 0.55 | FALSE |
30 | GTEx | Lung | CTB-50L17.5 | 0.24 | 0.05 | enet | 43 | 0.10 | 2.2e-08 | 5.59 | -5.1 | 3.0e-07 | -0.04 | 0.02 | 0.98 | FALSE |
31 | GTEx | Muscle Skeletal | CHAF1A | 0.18 | 0.21 | lasso | 2 | 0.20 | 9.7e-20 | 5.59 | -5.6 | 2.5e-08 | -0.03 | 0.02 | 0.98 | FALSE |
32 | GTEx | Muscle Skeletal | UBXN6 | 0.19 | 0.14 | lasso | 5 | 0.18 | 4.1e-17 | -4.81 | -6.1 | 9.9e-10 | -0.02 | 0.55 | 0.45 | FALSE |
33 | GTEx | Nerve Tibial | UBXN6 | 0.17 | 0.08 | enet | 20 | 0.09 | 4.4e-07 | 5.09 | -5.5 | 4.4e-08 | -0.07 | 0.05 | 0.95 | FALSE |
34 | GTEx | Nerve Tibial | CTB-50L17.5 | 0.11 | 0.08 | enet | 4 | 0.08 | 1.6e-06 | 5.37 | -5.5 | 4.7e-08 | -0.04 | 0.02 | 0.98 | FALSE |
35 | GTEx | Prostate | UBXN6 | 0.27 | 0.15 | enet | 19 | 0.14 | 2.4e-04 | 4.91 | -5.5 | 4.8e-08 | -0.04 | 0.08 | 0.38 | FALSE |
36 | GTEx | Skin Not Sun Exposed Suprapubic | AC007292.6 | 0.11 | 0.08 | lasso | 6 | 0.07 | 7.8e-05 | 5.83 | -5.5 | 3.8e-08 | -0.05 | 0.01 | 0.98 | FALSE |
37 | GTEx | Skin Sun Exposed Lower leg | CHAF1A | 0.19 | 0.18 | lasso | 1 | 0.17 | 5.1e-14 | 5.37 | -5.4 | 7.7e-08 | -0.03 | 0.03 | 0.97 | FALSE |
38 | GTEx | Stomach | AC007292.4 | 0.27 | 0.09 | lasso | 5 | 0.04 | 4.0e-03 | -5.14 | 5.3 | 1.2e-07 | 0.03 | 0.06 | 0.64 | FALSE |
39 | GTEx | Testis | CHAF1A | 0.18 | 0.09 | lasso | 2 | 0.07 | 4.0e-04 | 5.59 | -5.3 | 8.9e-08 | -0.03 | 0.02 | 0.88 | FALSE |
40 | GTEx | Testis | CTB-50L17.9 | 0.39 | 0.30 | enet | 36 | 0.34 | 9.4e-16 | 4.91 | -6.0 | 2.7e-09 | -0.06 | 0.16 | 0.84 | FALSE |
41 | GTEx | Thyroid | UBXN6 | 0.25 | 0.19 | lasso | 5 | 0.23 | 8.8e-18 | 5.83 | -5.6 | 1.9e-08 | -0.05 | 0.02 | 0.98 | FALSE |
42 | GTEx | Vagina | CTB-50L17.9 | 0.38 | 0.26 | lasso | 5 | 0.23 | 5.7e-06 | 5.59 | -5.6 | 2.0e-08 | -0.05 | 0.04 | 0.89 | FALSE |
43 | NTR | Blood | C19orf35 | 0.03 | 0.01 | enet | 9 | 0.02 | 3.7e-07 | -2.74 | -6.1 | 9.3e-10 | 0.38 | 0.96 | 0.03 | FALSE |
44 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UBXN6 | 0.05 | 0.01 | blup | 57 | 0.04 | 6.6e-05 | 5.59 | -7.0 | 2.2e-12 | -0.04 | 0.01 | 0.98 | TRUE |
45 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHAF1A | 0.12 | 0.11 | lasso | 3 | 0.12 | 7.9e-13 | 5.37 | -5.7 | 1.4e-08 | -0.05 | 0.01 | 0.99 | FALSE |
46 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | 8.78 | 9.2 | 4.9e-20 | -0.96 | 0.01 | 0.99 | TRUE |
47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MPND | 0.05 | 0.03 | lasso | 3 | 0.02 | 5.3e-03 | 5.23 | 5.2 | 2.6e-07 | 0.03 | 0.03 | 0.67 | FALSE |
48 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBXN6 | 0.18 | 0.17 | enet | 18 | 0.18 | 9.9e-20 | 5.59 | -5.4 | 6.3e-08 | -0.03 | 0.00 | 1.00 | FALSE |
49 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CHAF1A | 0.15 | 0.12 | lasso | 2 | 0.12 | 3.2e-07 | 5.37 | -5.4 | 7.0e-08 | -0.04 | 0.02 | 0.98 | FALSE |
50 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | JSRP1 | 0.07 | 0.04 | blup | 33 | 0.03 | 7.8e-03 | -3.90 | 5.8 | 7.4e-09 | -0.43 | 0.01 | 0.14 | FALSE |
51 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | -7.35 | 8.3 | 7.9e-17 | -0.87 | 0.03 | 0.94 | TRUE |
52 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHAF1A | 0.05 | 0.04 | lasso | 4 | 0.03 | 2.3e-04 | 5.59 | -5.3 | 1.1e-07 | -0.03 | 0.01 | 0.98 | FALSE |
53 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | JSRP1 | 0.03 | 0.00 | blup | 33 | 0.02 | 2.1e-03 | -3.10 | -6.1 | 1.3e-09 | 0.18 | 0.01 | 0.18 | TRUE |
54 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBXN6 | 0.04 | 0.03 | lasso | 2 | 0.02 | 1.6e-03 | 4.91 | -5.4 | 7.5e-08 | -0.03 | 0.00 | 0.91 | FALSE |
55 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHAF1A | 0.20 | 0.11 | lasso | 2 | 0.11 | 5.6e-05 | 5.83 | -5.9 | 3.2e-09 | -0.05 | 0.00 | 0.99 | FALSE |
56 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | UBXN6 | 0.23 | 0.11 | lasso | 5 | 0.12 | 2.5e-05 | 4.91 | -5.9 | 3.0e-09 | -0.06 | 0.02 | 0.75 | FALSE |
57 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBXN6 | 0.13 | 0.10 | lasso | 2 | 0.10 | 1.3e-10 | 5.59 | -5.9 | 3.3e-09 | -0.04 | 0.00 | 1.00 | FALSE |
58 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DOT1L | 0.40 | -0.01 | enet | 20 | 0.03 | 3.6e-02 | -3.66 | 6.2 | 7.9e-10 | -0.44 | 0.01 | 0.20 | FALSE |
59 | The Cancer Genome Atlas | Thyroid Carcinoma | UBXN6 | 0.16 | 0.12 | lasso | 2 | 0.12 | 5.4e-12 | 5.59 | -5.8 | 8.1e-09 | -0.04 | 0.00 | 1.00 | FALSE |