Best TWAS P=1.16e-24 · Best GWAS P=7.46e-21 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOSTRIN | 0.14 | 0.13 | lasso | 4 | 0.12 | 1.9e-14 | -9.4 | 10.3 | 1.2e-24 | -0.97 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | NOSTRIN | 0.11 | 0.03 | lasso | 4 | 0.04 | 1.6e-04 | -7.7 | 6.3 | 2.9e-10 | -0.22 | 0.10 | 0.87 | FALSE |
| 3 | GTEx | Adrenal Gland | NOSTRIN | 0.21 | 0.09 | lasso | 4 | 0.09 | 4.1e-04 | 7.9 | 8.1 | 5.8e-16 | -0.40 | 0.20 | 0.63 | FALSE |
| 4 | GTEx | Lung | NOSTRIN | 0.09 | 0.06 | lasso | 4 | 0.07 | 7.1e-06 | 9.1 | 8.4 | 3.1e-17 | -0.39 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Pancreas | NOSTRIN | 0.30 | 0.12 | enet | 17 | 0.08 | 3.3e-04 | -7.7 | 7.5 | 6.9e-14 | -0.47 | 0.09 | 0.88 | FALSE |
| 6 | GTEx | Stomach | NOSTRIN | 0.15 | 0.04 | enet | 9 | 0.09 | 6.8e-05 | 9.1 | 9.7 | 2.1e-22 | -0.58 | 0.03 | 0.96 | FALSE |
| 7 | GTEx | Testis | NOSTRIN | 0.43 | 0.17 | enet | 17 | 0.32 | 1.0e-14 | -7.1 | 8.5 | 1.7e-17 | -0.68 | 0.08 | 0.92 | FALSE |
| 8 | METSIM | Adipose | NOSTRIN | 0.07 | 0.09 | lasso | 6 | 0.08 | 1.6e-12 | 9.1 | 9.0 | 2.0e-19 | -0.59 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NOSTRIN | 0.03 | 0.01 | blup | 55 | 0.02 | 9.5e-05 | -7.2 | 8.1 | 5.5e-16 | -0.37 | 0.03 | 0.93 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | G6PC2 | 0.32 | 0.07 | blup | 29 | 0.06 | 3.8e-04 | -6.8 | -8.4 | 6.0e-17 | 0.79 | 0.02 | 0.76 | FALSE |
| 11 | The Cancer Genome Atlas | Glioblastoma Multiforme | NOSTRIN | 0.25 | 0.01 | blup | 55 | 0.08 | 2.0e-03 | -7.2 | 6.7 | 2.0e-11 | -0.25 | 0.01 | 0.62 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NOSTRIN | 0.09 | 0.03 | enet | 5 | 0.09 | 1.7e-10 | 7.3 | 6.5 | 6.4e-11 | -0.19 | 0.04 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | G6PC2 | 0.47 | 0.23 | enet | 8 | 0.28 | 4.4e-32 | -6.8 | -7.7 | 1.7e-14 | 0.79 | 0.79 | 0.21 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOSTRIN | 0.12 | 0.13 | lasso | 7 | 0.14 | 4.5e-15 | -7.2 | 8.5 | 2.4e-17 | -0.43 | 0.17 | 0.83 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | G6PC2 | 0.56 | 0.13 | blup | 29 | 0.16 | 2.1e-09 | -6.8 | -8.0 | 1.1e-15 | 0.75 | 0.06 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOSTRIN | 0.08 | 0.01 | enet | 6 | 0.04 | 2.1e-05 | 7.7 | 8.4 | 3.7e-17 | -0.32 | 0.01 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | NOSTRIN | 0.04 | 0.00 | blup | 55 | 0.01 | 1.6e-02 | 7.8 | 6.2 | 5.7e-10 | -0.23 | 0.00 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NOSTRIN | 0.05 | 0.00 | blup | 55 | 0.01 | 1.1e-02 | -7.2 | 7.7 | 1.0e-14 | -0.38 | 0.01 | 0.67 | FALSE |
| 19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NOSTRIN | 0.17 | 0.07 | lasso | 2 | 0.08 | 4.3e-04 | 7.3 | 7.9 | 2.7e-15 | -0.44 | 0.01 | 0.95 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOSTRIN | 0.06 | 0.01 | blup | 55 | 0.01 | 2.9e-02 | -6.3 | 6.3 | 3.0e-10 | -0.23 | 0.12 | 0.70 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | G6PC2 | 0.22 | 0.01 | enet | 4 | 0.08 | 3.1e-06 | -6.8 | -6.3 | 3.3e-10 | 0.71 | 0.08 | 0.50 | FALSE |
| 22 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NOSTRIN | 0.27 | 0.04 | lasso | 3 | 0.08 | 2.8e-03 | 7.8 | 7.5 | 8.5e-14 | -0.44 | 0.01 | 0.57 | FALSE |