Best TWAS P=7.3e-19 · Best GWAS P=1.86e-19 conditioned to 0.00293
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | 6.7 | 7.4 | 1.7e-13 | 0.63 | 0.91 | 0.09 | FALSE |
| 2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | -4.4 | -5.4 | 8.8e-08 | -0.40 | 0.06 | 0.14 | FALSE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | 8.8 | 8.7 | 3.1e-18 | 0.79 | 0.07 | 0.93 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | 8.7 | 8.9 | 7.3e-19 | 0.83 | 0.05 | 0.95 | TRUE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | 8.3 | 6.1 | 1.4e-09 | 0.78 | 0.09 | 0.65 | FALSE |