Best TWAS P=7.94e-10 · Best GWAS P=2.36e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SNHG7 | 0.61 | 0.45 | bslmm | 381 | 0.47 | 2.1e-64 | 6 | -5.8 | 5.5e-09 | -0.98 | 0 | 1.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | SNHG7 | 0.42 | 0.30 | lasso | 3 | 0.30 | 3.8e-25 | 6 | -5.9 | 3.6e-09 | -1.00 | 0 | 1.00 | FALSE |
3 | GTEx | Artery Aorta | SNHG7 | 0.37 | 0.26 | lasso | 3 | 0.33 | 8.2e-19 | 6 | -5.6 | 1.6e-08 | -0.90 | 0 | 1.00 | FALSE |
4 | GTEx | Artery Tibial | SNHG7 | 0.28 | 0.26 | enet | 5 | 0.26 | 2.2e-20 | 6 | -5.9 | 4.3e-09 | -0.96 | 0 | 1.00 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | SNHG7 | 0.52 | 0.42 | lasso | 2 | 0.42 | 3.9e-34 | 6 | -6.0 | 2.0e-09 | -1.00 | 0 | 1.00 | FALSE |
6 | GTEx | Colon Transverse | SNHG7 | 0.18 | 0.14 | lasso | 6 | 0.13 | 7.6e-07 | 6 | -5.8 | 8.4e-09 | -0.94 | 0 | 1.00 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | SNHG7 | 0.38 | 0.37 | lasso | 5 | 0.35 | 1.7e-13 | 6 | -5.8 | 5.3e-09 | -0.99 | 0 | 1.00 | FALSE |
8 | GTEx | Esophagus Muscularis | SNHG7 | 0.29 | 0.33 | lasso | 1 | 0.33 | 1.1e-20 | 6 | -6.0 | 2.4e-09 | -1.00 | 0 | 1.00 | FALSE |
9 | GTEx | Muscle Skeletal | SNHG7 | 0.18 | 0.18 | lasso | 2 | 0.18 | 6.3e-17 | 6 | -5.8 | 5.3e-09 | -0.99 | 0 | 1.00 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | SNHG7 | 0.34 | 0.21 | lasso | 5 | 0.26 | 9.0e-22 | 6 | -5.8 | 5.9e-09 | -0.91 | 0 | 1.00 | FALSE |
11 | GTEx | Stomach | SNHG7 | 0.20 | 0.13 | enet | 14 | 0.08 | 1.0e-04 | 6 | -5.7 | 1.1e-08 | -0.86 | 0 | 1.00 | FALSE |
12 | GTEx | Testis | SNHG7 | 0.40 | 0.42 | lasso | 2 | 0.41 | 2.0e-19 | 6 | -6.0 | 2.1e-09 | -1.00 | 0 | 1.00 | FALSE |
13 | GTEx | Thyroid | SNHG7 | 0.20 | 0.22 | lasso | 1 | 0.21 | 4.1e-16 | 6 | -6.0 | 2.4e-09 | -1.00 | 0 | 1.00 | FALSE |
14 | YFS | Blood | SNHG7 | 0.59 | 0.38 | enet | 18 | 0.39 | 2.6e-137 | 6 | -5.9 | 2.7e-09 | -0.98 | 0 | 1.00 | FALSE |
15 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SNHG7 | 0.32 | 0.13 | lasso | 4 | 0.12 | 1.0e-10 | 6 | -6.1 | 1.0e-09 | -0.96 | 0 | 1.00 | FALSE |
16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNHG7 | 0.32 | 0.20 | lasso | 2 | 0.20 | 6.7e-40 | 6 | -5.9 | 3.3e-09 | -1.00 | 0 | 1.00 | FALSE |
17 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SNHG7 | 0.35 | 0.18 | lasso | 3 | 0.18 | 2.7e-09 | 6 | -6.0 | 2.2e-09 | -1.00 | 0 | 1.00 | FALSE |
18 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNHG7 | 0.32 | 0.22 | enet | 11 | 0.22 | 5.1e-13 | 6 | -5.3 | 1.1e-07 | -0.93 | 0 | 1.00 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SNHG7 | 0.44 | 0.30 | lasso | 3 | 0.31 | 7.2e-35 | 6 | -5.8 | 6.2e-09 | -1.00 | 0 | 1.00 | FALSE |
20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SNHG7 | 0.52 | 0.33 | lasso | 3 | 0.33 | 2.0e-19 | 6 | -5.9 | 2.9e-09 | -1.00 | 0 | 1.00 | FALSE |
21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNHG7 | 0.58 | 0.37 | lasso | 4 | 0.38 | 1.1e-45 | 6 | -5.6 | 2.5e-08 | -0.98 | 0 | 1.00 | FALSE |
22 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SNHG7 | 0.27 | 0.09 | lasso | 3 | 0.12 | 4.5e-06 | 6 | -5.2 | 2.0e-07 | -0.95 | 0 | 1.00 | FALSE |
23 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNHG7 | 0.29 | 0.15 | enet | 5 | 0.16 | 2.5e-18 | 6 | -5.3 | 1.0e-07 | -0.96 | 0 | 1.00 | FALSE |
24 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SNHG7 | 0.24 | 0.16 | enet | 13 | 0.16 | 9.6e-18 | 6 | -5.7 | 1.4e-08 | -0.95 | 0 | 1.00 | FALSE |
25 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SNHG7 | 0.26 | 0.12 | lasso | 1 | 0.11 | 6.9e-08 | 6 | -6.0 | 2.4e-09 | -1.00 | 0 | 1.00 | FALSE |
26 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SNHG7 | 0.34 | 0.22 | enet | 8 | 0.23 | 6.2e-10 | 6 | -5.4 | 8.6e-08 | -0.92 | 0 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNHG7 | 0.51 | 0.37 | enet | 3 | 0.38 | 2.4e-42 | 6 | -5.7 | 1.0e-08 | -0.98 | 0 | 1.00 | FALSE |
28 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SNHG7 | 0.42 | 0.16 | lasso | 5 | 0.23 | 5.1e-14 | 6 | -5.5 | 3.4e-08 | -0.96 | 0 | 1.00 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | SNHG7 | 0.53 | 0.40 | lasso | 3 | 0.41 | 9.4e-43 | 6 | -6.1 | 7.9e-10 | -0.99 | 0 | 1.00 | TRUE |
30 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SNHG7 | 0.30 | 0.15 | lasso | 8 | 0.12 | 3.4e-04 | 6 | -5.9 | 2.7e-09 | -0.98 | 0 | 0.97 | FALSE |