Best TWAS P=1.63e-21 · Best GWAS P=1.72e-32 conditioned to 7.22e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HACE1 | 0.14 | 0.10 | enet | 28 | 0.11 | 8.9e-14 | 4.5 | -6.3 | 2.5e-10 | -0.44 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LIN28B | 0.04 | 0.04 | lasso | 9 | 0.03 | 3.9e-05 | 9.6 | 9.5 | 1.6e-21 | 0.74 | 0.24 | 0.75 | TRUE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | HACE1 | 0.40 | 0.15 | lasso | 8 | 0.22 | 1.1e-07 | 5.4 | -6.4 | 1.6e-10 | -0.45 | 0.57 | 0.36 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | HACE1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 3.0e-02 | 3.2 | -5.2 | 1.7e-07 | -0.36 | 0.09 | 0.46 | FALSE |
| 5 | GTEx | Lung | HACE1 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.2e-01 | -1.3 | -6.8 | 7.7e-12 | -0.58 | 0.05 | 0.33 | FALSE |
| 6 | GTEx | Thyroid | HACE1 | 0.08 | 0.06 | lasso | 4 | 0.04 | 8.9e-04 | 5.4 | -5.5 | 4.6e-08 | -0.37 | 0.25 | 0.06 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | HACE1 | 0.16 | 0.16 | lasso | 5 | 0.16 | 1.4e-20 | 5.4 | -5.5 | 5.0e-08 | -0.38 | 1.00 | 0.00 | FALSE |